SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uf3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		4 / 7 GLY A  71
TYR A 131
ASN A  41
ASP A  51
 None
 1.07A 2g72B-1uf3A:
undetectable		 2g72B-1uf3A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		4 / 5 TYR A  68
ALA A  62
ALA A  10
TYR A 212
 None
 1.23A 3d91A-1uf3A:
undetectable		 3d91A-1uf3A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		3 / 3 SER A  12
GLY A 205
SER A 208
 None
 0.65A 3loqA-1uf3A:
undetectable		 3loqA-1uf3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		5 / 12 LEU A  27
GLY A  32
ALA A  33
ASP A  34
LEU A   9
 None
 0.96A 3ogqB-1uf3A:
undetectable		 3ogqB-1uf3A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		4 / 4 LEU A  21
ILE A   8
TYR A 212
TYR A  68
 None
 1.14A 3vt7A-1uf3A:
undetectable		 3vt7A-1uf3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		3 / 3 ASN A  86
GLU A  83
ARG A  82
 None
 1.09A 3wxoA-1uf3A:
0.0		 3wxoA-1uf3A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		4 / 7 ALA A 111
LEU A 140
LEU A 143
TRP A 104
 None
 1.07A 4iomA-1uf3A:
3.3		 4iomA-1uf3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		5 / 12 TYR A 131
GLY A 112
ALA A 136
VAL A  69
ILE A  39
 None
 0.98A 4rvdA-1uf3A:
undetectable		 4rvdA-1uf3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		5 / 12 GLY A 112
ALA A 136
ARG A  95
VAL A  69
ILE A  39
 None
 1.14A 4rvgA-1uf3A:
undetectable		 4rvgA-1uf3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		5 / 11 GLY A  40
LEU A  42
LEU A 185
ALA A  37
PHE A  55
 None
 1.08A 4wnuA-1uf3A:
undetectable		 4wnuA-1uf3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		5 / 8 ALA A  37
LEU A 185
LEU A 183
LEU A 217
ALA A  35
 None
 1.14A 4z90A-1uf3A:
undetectable
4z90B-1uf3A:
undetectable
4z90C-1uf3A:
undetectable
4z90D-1uf3A:
undetectable
4z90E-1uf3A:
undetectable		 4z90A-1uf3A:
20.25
4z90B-1uf3A:
20.25
4z90C-1uf3A:
20.25
4z90D-1uf3A:
20.25
4z90E-1uf3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		3 / 3 LYS A 221
ASP A 216
ARG A 220
 None
 1.08A 5jwaA-1uf3A:
undetectable
5jwaH-1uf3A:
undetectable		 5jwaA-1uf3A:
16.18
5jwaH-1uf3A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		3 / 3 LEU A 154
GLY A  40
PHE A  56
 None
 0.61A 6exiC-1uf3A:
undetectable		 6exiC-1uf3A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 1uf3 HYPOTHETICAL PROTEIN
TT1561
(Thermus
thermophilus) 		3 / 3 ARG A 228
GLY A 210
GLU A 211
 None
 0.50A 6fgdA-1uf3A:
1.5		 6fgdA-1uf3A:
20.79