SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ufa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 5 LYS A 324
LEU A 285
GLU A 327
ALA A 323
 None
 0.98A 1eta1-1ufaA:
undetectable		 1eta1-1ufaA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 5 LYS A 324
LEU A 285
GLU A 327
ALA A 323
 None
 0.97A 1eta2-1ufaA:
undetectable		 1eta2-1ufaA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 6 LYS A 324
LEU A 285
GLU A 327
ALA A 323
 None
 0.95A 1etb1-1ufaA:
undetectable		 1etb1-1ufaA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 6 LYS A 324
LEU A 285
GLU A 327
ALA A 323
 None
 0.94A 1etb2-1ufaA:
undetectable		 1etb2-1ufaA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 4 THR A  35
LEU A  39
VAL A  42
LEU A  46
 None
 0.60A 1fbmB-1ufaA:
undetectable		 1fbmB-1ufaA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 4 THR A  35
LEU A  39
VAL A  42
LEU A  46
 None
 0.54A 1fbmD-1ufaA:
undetectable		 1fbmD-1ufaA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 5 THR A  35
LEU A  39
VAL A  42
LEU A  46
 None
 0.46A 1fbmE-1ufaA:
undetectable		 1fbmE-1ufaA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 7 ALA A 449
GLU A 452
LEU A 453
MET A 432
 None
 0.48A 1hk2A-1ufaA:
undetectable		 1hk2A-1ufaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A 151
PRO A 196
LEU A 414
ARG A 411
 None
 1.39A 1hrkB-1ufaA:
undetectable		 1hrkB-1ufaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 7 HIS A 300
LEU A 295
SER A 296
ASP A  90
 None
 1.15A 1ismB-1ufaA:
undetectable		 1ismB-1ufaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 5 TYR A 426
GLU A 429
PHE A 486
TYR A 421
 None
 1.35A 1mclA-1ufaA:
0.0
1mclB-1ufaA:
0.0
1mclP-1ufaA:
undetectable		 1mclA-1ufaA:
16.12
1mclB-1ufaA:
16.12
1mclP-1ufaA:
0.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		3 / 3 THR A  35
LEU A  39
VAL A  42
 None
 0.45A 1mz9E-1ufaA:
undetectable		 1mz9E-1ufaA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QYX_A_ASDA500_1
(ESTRADIOL 17
BETA-DEHYDROGENASE 1)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 9 VAL A  15
LEU A  28
TYR A  36
PHE A  23
GLU A  30
 None
 1.42A 1qyxA-1ufaA:
1.0		 1qyxA-1ufaA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 8 LEU A   6
LEU A 356
VAL A 273
VAL A 371
 None
 0.91A 2bdmA-1ufaA:
2.5		 2bdmA-1ufaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 8 LEU A 260
VAL A 222
LEU A 263
VAL A 390
 None
 0.94A 2bdmA-1ufaA:
2.5		 2bdmA-1ufaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_A_CHDA1_0
(LIVER
CARBOXYLESTERASE 1)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 5 TRP A 181
GLY A 165
LEU A 212
PRO A 183
 None
 1.13A 2dqyA-1ufaA:
0.9		 2dqyA-1ufaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A 151
PRO A 196
LEU A 414
ARG A 411
 None
 1.37A 2hrcA-1ufaA:
undetectable		 2hrcA-1ufaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A 151
PRO A 196
LEU A 414
ARG A 411
 None
 1.39A 2hrcB-1ufaA:
undetectable		 2hrcB-1ufaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 8 HIS A 146
HIS A   9
ALA A 354
LEU A  63
THR A  60
 None
 1.49A 2it4A-1ufaA:
undetectable		 2it4A-1ufaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A 151
PRO A 196
LEU A 414
ARG A 411
 None
 1.34A 2pnjB-1ufaA:
undetectable		 2pnjB-1ufaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 6 LYS A 324
LEU A 285
GLU A 327
ALA A 323
 None
 0.96A 2roxB-1ufaA:
undetectable		 2roxB-1ufaA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A   8
LEU A  57
PHE A  55
LEU A 368
 None
 0.96A 2vq5B-1ufaA:
undetectable		 2vq5B-1ufaA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A  75
ASP A  82
TYR A  29
ARG A  86
 None
 1.30A 3arrA-1ufaA:
3.5		 3arrA-1ufaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A  75
ASP A  82
TYR A  29
ARG A  86
 None
 1.26A 3aruA-1ufaA:
undetectable		 3aruA-1ufaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A 151
PRO A 196
LEU A 414
ARG A 411
 None
 1.37A 3hcoB-1ufaA:
undetectable		 3hcoB-1ufaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		3 / 3 GLU A 429
GLU A 457
TRP A 422
 None
 1.29A 3hrdA-1ufaA:
undetectable
3hrdE-1ufaA:
undetectable
3hrdF-1ufaA:
undetectable		 3hrdA-1ufaA:
22.69
3hrdE-1ufaA:
22.69
3hrdF-1ufaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 5 THR A 145
ILE A  62
PHE A 507
LEU A 455
 None
 1.05A 3tf1A-1ufaA:
0.0		 3tf1A-1ufaA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 6 HIS A  11
GLU A 184
ASP A 460
SER A 459
PRO A 183
 None
 1.32A 4apjA-1ufaA:
4.3
4apjP-1ufaA:
undetectable		 4apjA-1ufaA:
23.39
4apjP-1ufaA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		3 / 3 TRP A 404
TRP A 274
THR A 270
 None
 1.31A 4bboB-1ufaA:
undetectable		 4bboB-1ufaA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 11 LEU A  57
THR A  56
ALA A 354
THR A  35
VAL A 365
 None
 0.96A 4e0fA-1ufaA:
undetectable		 4e0fA-1ufaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A 425
ALA A 449
GLU A 452
LEU A 455
LEU A 456
 None
 0.96A 4i1rA-1ufaA:
undetectable		 4i1rA-1ufaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 8 LYS A 292
ARG A  83
ARG A  86
GLU A  25
 None
 1.38A 4kr4C-1ufaA:
undetectable		 4kr4C-1ufaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 226
TYR A 148
VAL A 208
GLY A 207
LEU A 182
 None
 1.20A 4ot2A-1ufaA:
3.7		 4ot2A-1ufaA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 12 ARG A 287
GLY A 282
ALA A 366
GLY A 364
GLU A  34
 None
 1.23A 4r29C-1ufaA:
undetectable		 4r29C-1ufaA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 5 SER A 258
ARG A 387
GLY A 179
THR A 385
GLU A 138
 None
 1.39A 5btiA-1ufaA:
undetectable
5btiB-1ufaA:
undetectable		 5btiA-1ufaA:
20.70
5btiB-1ufaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 5 SER A 258
ARG A 387
GLY A 179
THR A 385
GLU A 138
 None
 1.47A 5btiC-1ufaA:
undetectable
5btiD-1ufaA:
undetectable		 5btiC-1ufaA:
20.70
5btiD-1ufaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 5 TYR A 421
PHE A 486
HIS A 481
LEU A 453
 None
 1.32A 5csyB-1ufaA:
3.2		 5csyB-1ufaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 128
TYR A  36
LEU A 120
ALA A 127
LEU A   8
 None
 1.40A 5ljbA-1ufaA:
undetectable		 5ljbA-1ufaA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		3 / 3 GLU A 288
TRP A 360
HIS A 299
 None
 1.10A 5xipA-1ufaA:
undetectable		 5xipA-1ufaA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		3 / 3 TYR A 515
ALA A 510
LEU A 454
 None
 0.76A 6d9kF-1ufaA:
undetectable		 6d9kF-1ufaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 387
LYS A 175
TYR A 169
 None
 1.31A 6gnaA-1ufaA:
undetectable		 6gnaA-1ufaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 387
LYS A 175
TYR A 169
 None
 1.31A 6gnbA-1ufaA:
undetectable		 6gnbA-1ufaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1ufa TT1467 PROTEIN
(Thermus
thermophilus) 		4 / 8 GLY A  75
PHE A  76
GLY A  24
ALA A  31
 None
 0.70A 6hu9H-1ufaA:
undetectable
6hu9e-1ufaA:
1.6		 6hu9H-1ufaA:
11.66
6hu9e-1ufaA:
13.10