SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ufo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 10 LEU A  30
ALA A 110
LEU A  28
LEU A  44
LEU A  54
 None
 1.35A 1ie4A-1ufoA:
0.0
1ie4C-1ufoA:
0.0		 1ie4A-1ufoA:
20.00
1ie4C-1ufoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		6 / 12 GLY A 111
GLY A 112
LEU A 219
LEU A 176
MET A 223
HIS A 177
 None
 1.33A 1ya4C-1ufoA:
14.5		 1ya4C-1ufoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		4 / 4 GLY A  32
SER A 113
ILE A 185
HIS A 217
 None
 1.30A 1yajJ-1ufoA:
13.9		 1yajJ-1ufoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		3 / 3 TRP A 234
ARG A 130
PHE A 108
 None
 1.47A 1zeaH-1ufoA:
undetectable
1zeaL-1ufoA:
undetectable		 1zeaH-1ufoA:
20.37
1zeaL-1ufoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 12 TYR A  77
GLY A  32
GLY A 112
ALA A  29
VAL A  81
 None
 1.12A 2zulA-1ufoA:
undetectable		 2zulA-1ufoA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		4 / 5 ARG A 190
MET A 191
THR A 194
LEU A 195
 None
 1.44A 3ag2J-1ufoA:
undetectable		 3ag2J-1ufoA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 12 VAL A 118
LEU A  13
GLU A  91
ARG A  65
HIS A  62
 None
 1.39A 3apvA-1ufoA:
undetectable		 3apvA-1ufoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 12 VAL A 118
LEU A  13
GLU A  91
ARG A  65
HIS A  62
 None
 1.35A 3apvB-1ufoA:
undetectable		 3apvB-1ufoA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		3 / 3 LEU A  26
LEU A 107
ARG A 101
 None
 0.74A 3hcnB-1ufoA:
3.1		 3hcnB-1ufoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 9 LEU A 133
HIS A 177
HIS A 120
ILE A 136
LEU A 178
 None
 1.25A 3hy7B-1ufoA:
2.1		 3hy7B-1ufoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 12 VAL A 132
LEU A 175
ALA A 224
GLY A 115
ALA A 116
 None
 1.02A 3ln1B-1ufoA:
undetectable		 3ln1B-1ufoA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 12 VAL A 132
LEU A 175
ALA A 224
GLY A 115
ALA A 116
 None
 1.01A 3ln1D-1ufoA:
undetectable		 3ln1D-1ufoA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		6 / 12 VAL A 132
GLY A 115
ALA A 110
LEU A 109
LEU A 121
PRO A 163
 None
 1.29A 3mb5A-1ufoA:
3.1		 3mb5A-1ufoA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 11 ARG A  18
LEU A  41
ALA A 110
GLY A 227
PRO A  45
 None
 1.15A 3spkA-1ufoA:
undetectable		 3spkA-1ufoA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		4 / 7 ARG A  18
LEU A  41
ALA A 110
GLY A 227
 None
 0.82A 3spkB-1ufoA:
undetectable		 3spkB-1ufoA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 9 ARG A  18
LEU A  41
ALA A 110
GLY A 227
PRO A  45
 None
 1.15A 3spkA-1ufoA:
undetectable		 3spkA-1ufoA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		3 / 3 ARG A 182
HIS A 184
SER A 181
 None
 0.85A 4mjwA-1ufoA:
undetectable
4mjwB-1ufoA:
undetectable		 4mjwA-1ufoA:
19.74
4mjwB-1ufoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		3 / 3 SER A 181
ARG A 182
HIS A 184
 None
 0.82A 4mjwA-1ufoA:
undetectable
4mjwB-1ufoA:
undetectable		 4mjwA-1ufoA:
19.74
4mjwB-1ufoA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		6 / 12 ALA A  85
GLU A 125
VAL A 118
ALA A  59
LEU A 107
ALA A  92
 None
 1.37A 4v01A-1ufoA:
undetectable		 4v01A-1ufoA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		6 / 12 ALA A  85
GLU A 125
VAL A 118
ALA A  59
LEU A 107
ALA A  92
 None
 1.37A 4v01B-1ufoA:
undetectable		 4v01B-1ufoA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		4 / 5 TYR A  47
HIS A 217
PRO A 221
PHE A 135
 None
 1.31A 4ze2A-1ufoA:
undetectable		 4ze2A-1ufoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 12 GLY A  35
GLY A  32
LEU A  16
LEU A  41
HIS A  39
 None
 1.00A 5twjA-1ufoA:
undetectable		 5twjA-1ufoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		5 / 10 GLY A  35
GLY A  32
LEU A  16
LEU A  41
HIS A  39
 None
 1.01A 5twjB-1ufoA:
undetectable		 5twjB-1ufoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1ufo HYPOTHETICAL PROTEIN
TT1662
(Thermus
thermophilus) 		4 / 4 HIS A 177
VAL A 132
LEU A 175
ALA A 134
 None
 1.45A 6d8pB-1ufoA:
3.7		 6d8pB-1ufoA:
15.72