SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ufr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		3 / 3 ALA A  21
HIS A  22
VAL A  25
 None
 0.26A 1lqtB-1ufrA:
undetectable		 1lqtB-1ufrA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		3 / 3 ALA A  21
HIS A  22
VAL A  25
 None
 0.27A 1lquB-1ufrA:
undetectable		 1lquB-1ufrA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A 101
VAL A  37
GLY A  38
VAL A  85
 None
 0.96A 1t88A-1ufrA:
undetectable		 1t88A-1ufrA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		4 / 8 LEU A 101
VAL A  37
GLY A  38
VAL A  85
 None
 0.91A 2a1oA-1ufrA:
undetectable		 2a1oA-1ufrA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  67
GLY A  38
GLY A  43
THR A  70
ALA A 115
 None
 1.02A 2egvA-1ufrA:
undetectable		 2egvA-1ufrA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  67
VAL A  37
GLY A  38
GLY A  43
THR A 111
 None
None
None
None
CL  A 182 (-4.2A)
 1.00A 2egvA-1ufrA:
undetectable		 2egvA-1ufrA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A  67
VAL A  37
GLY A  38
GLY A  43
THR A 111
 None
None
None
None
CL  A 182 (-4.2A)
 0.98A 2egvB-1ufrA:
undetectable		 2egvB-1ufrA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A  65
ILE A  50
ALA A  21
VAL A  62
PRO A  63
 None
 1.07A 2nnhA-1ufrA:
undetectable		 2nnhA-1ufrA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		4 / 8 THR A 154
VAL A 105
LEU A 175
VAL A 173
 None
 0.81A 2zujA-1ufrA:
undetectable		 2zujA-1ufrA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 9 GLY A  43
HIS A  40
ASP A 104
VAL A 164
VAL A 167
 None
 1.29A 3fi0F-1ufrA:
0.0		 3fi0F-1ufrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 149
ALA A  16
PHE A 147
ASP A 146
ALA A 145
 None
 1.14A 3id6C-1ufrA:
undetectable		 3id6C-1ufrA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 149
ALA A  16
PHE A 147
ALA A 145
VAL A 132
 None
 1.20A 3nvkF-1ufrA:
undetectable
3nvkJ-1ufrA:
undetectable		 3nvkF-1ufrA:
20.11
3nvkJ-1ufrA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 149
ALA A  16
PHE A 147
ASP A 146
ALA A 145
 None
 1.18A 3nvkF-1ufrA:
undetectable
3nvkJ-1ufrA:
undetectable		 3nvkF-1ufrA:
20.11
3nvkJ-1ufrA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		4 / 5 ILE A  50
ALA A 131
HIS A  22
ARG A  19
 None
 0.93A 4ac9B-1ufrA:
3.3
4ac9C-1ufrA:
undetectable		 4ac9B-1ufrA:
17.28
4ac9C-1ufrA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		4 / 5 ILE A  50
ALA A 131
HIS A  22
ARG A  19
 None
 0.96A 4acaB-1ufrA:
3.2
4acaC-1ufrA:
3.0		 4acaB-1ufrA:
17.28
4acaC-1ufrA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 115
LEU A 119
ALA A 145
ILE A  24
GLY A  38
 None
 0.97A 4r3aB-1ufrA:
undetectable		 4r3aB-1ufrA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 109
ARG A 110
ASN A 151
LEU A 106
THR A 154
 CL  A 182 (-3.2A)
None
None
None
None
 1.41A 5fhzA-1ufrA:
undetectable		 5fhzA-1ufrA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 101
ILE A  39
GLY A  38
GLY A  65
ALA A 115
 None
 1.08A 5o96C-1ufrA:
undetectable
5o96D-1ufrA:
undetectable		 5o96C-1ufrA:
21.26
5o96D-1ufrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  25
THR A  31
PHE A  57
VAL A 100
TYR A 129
 None
 1.46A 6drxA-1ufrA:
undetectable		 6drxA-1ufrA:
17.07