SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ufv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		3 / 3 ARG A 183
ARG A  68
ARG A 117
 CL  A1001 ( 3.2A)
None
CL  A1001 ( 3.0A)
 0.83A 1l7fA-1ufvA:
undetectable		 1l7fA-1ufvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		3 / 3 ARG A 183
ARG A  68
ARG A 117
 CL  A1001 ( 3.2A)
None
CL  A1001 ( 3.0A)
 0.86A 1l7hA-1ufvA:
undetectable		 1l7hA-1ufvA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 11 HIS A  29
GLY A  31
HIS A  32
ASP A 146
VAL A 172
 CL  A1002 (-4.8A)
None
GOL  A1300 (-4.6A)
None
None
 0.81A 1pg2A-1ufvA:
4.9		 1pg2A-1ufvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 12 HIS A  29
GLY A  31
HIS A  32
GLY A 143
VAL A 172
 CL  A1002 (-4.8A)
None
GOL  A1300 (-4.6A)
None
None
 0.76A 1qu2A-1ufvA:
3.7		 1qu2A-1ufvA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 12 HIS A  29
HIS A  32
GLY A 143
ASP A 146
VAL A 172
 CL  A1002 (-4.8A)
GOL  A1300 (-4.6A)
None
None
None
 1.09A 1qu2A-1ufvA:
3.7		 1qu2A-1ufvA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 12 HIS A  29
GLY A  31
HIS A  32
ASP A 146
VAL A 172
 CL  A1002 (-4.8A)
None
GOL  A1300 (-4.6A)
None
None
 1.01A 1qu3A-1ufvA:
undetectable		 1qu3A-1ufvA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 12 GLU A  61
ASP A  62
ALA A 260
ILE A 269
ARG A 262
 GOL  A 600 (-3.7A)
GOL  A 600 (-3.1A)
None
None
GOL  A 600 ( 4.2A)
 1.31A 1s14B-1ufvA:
undetectable		 1s14B-1ufvA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		3 / 3 ARG A 154
VAL A  22
GLY A  31
 None
 0.60A 2avvE-1ufvA:
undetectable		 2avvE-1ufvA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		3 / 3 PRO A  23
LEU A  35
ARG A  38
 GOL  A1400 (-4.8A)
None
None
 0.90A 3aqiA-1ufvA:
undetectable		 3aqiA-1ufvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		4 / 6 GLN A 149
HIS A  32
HIS A  29
ASP A 146
 GOL  A1400 (-3.1A)
GOL  A1300 (-4.6A)
CL  A1002 (-4.8A)
None
 1.04A 3nvcA-1ufvA:
undetectable		 3nvcA-1ufvA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		3 / 3 ARG A  72
LEU A  76
THR A  24
 None
None
GOL  A1300 (-4.4A)
 0.91A 3oxcA-1ufvA:
undetectable		 3oxcA-1ufvA:
15.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		6 / 8 ARG A 117
HIS A 120
VAL A 124
VAL A 128
ASP A 146
ARG A 183
 CL  A1001 ( 3.0A)
CL  A1001 (-4.7A)
GOL  A1400 ( 4.6A)
None
None
CL  A1001 ( 3.2A)
 1.38A 3uy4A-1ufvA:
39.2		 3uy4A-1ufvA:
41.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		8 / 8 GLN A  56
ARG A 117
HIS A 120
VAL A 124
VAL A 127
ASP A 146
GLN A 149
ARG A 183
 GOL  A1400 ( 3.2A)
CL  A1001 ( 3.0A)
CL  A1001 (-4.7A)
GOL  A1400 ( 4.6A)
None
None
GOL  A1400 (-3.1A)
CL  A1001 ( 3.2A)
 0.34A 3uy4A-1ufvA:
39.2		 3uy4A-1ufvA:
41.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		4 / 7 LEU A  28
ALA A  48
VAL A  47
ALA A  80
 None
 0.74A 4g77A-1ufvA:
undetectable		 4g77A-1ufvA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 11 GLY A 257
LEU A 219
VAL A 215
ILE A 258
TRP A 112
 None
 1.44A 4pghC-1ufvA:
undetectable		 4pghC-1ufvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 12 ILE A 258
GLY A 257
ALA A 218
HIS A 241
VAL A 240
 None
 1.01A 4rvdA-1ufvA:
undetectable		 4rvdA-1ufvA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 12 GLU A  61
ASP A  62
ALA A 260
ILE A 269
ARG A 262
 GOL  A 600 (-3.7A)
GOL  A 600 (-3.1A)
None
None
GOL  A 600 ( 4.2A)
 1.22A 4uroC-1ufvA:
undetectable		 4uroC-1ufvA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		11 / 12 HIS A  29
GLY A  31
LEU A  35
GLN A  56
TYR A  66
VAL A 127
GLY A 143
LYS A 145
ASP A 146
THR A 171
LEU A 180
 CL  A1002 (-4.8A)
None
None
GOL  A1400 ( 3.2A)
None
None
None
None
None
None
None
 0.53A 5hg0A-1ufvA:
32.4		 5hg0A-1ufvA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		6 / 12 HIS A  29
GLY A  31
VAL A 128
LYS A 145
ASP A 146
LEU A 180
 CL  A1002 (-4.8A)
None
None
None
None
None
 1.25A 5hg0A-1ufvA:
32.4		 5hg0A-1ufvA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		10 / 12 HIS A  29
GLY A  31
HIS A  32
LEU A  35
TYR A  66
VAL A 127
GLY A 143
ASP A 146
THR A 171
LEU A 180
 CL  A1002 (-4.8A)
None
GOL  A1300 (-4.6A)
None
None
None
None
None
None
None
 0.34A 5hg0B-1ufvA:
32.3		 5hg0B-1ufvA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 12 HIS A  29
GLY A  31
HIS A  32
TYR A  66
VAL A 124
 CL  A1002 (-4.8A)
None
GOL  A1300 (-4.6A)
None
GOL  A1400 ( 4.6A)
 1.06A 5hg0B-1ufvA:
32.3		 5hg0B-1ufvA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		6 / 12 HIS A  29
GLY A  31
HIS A  32
VAL A 128
ASP A 146
LEU A 180
 CL  A1002 (-4.8A)
None
GOL  A1300 (-4.6A)
None
None
None
 1.15A 5hg0B-1ufvA:
32.3		 5hg0B-1ufvA:
34.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		9 / 12 HIS A  32
LEU A  35
TYR A  66
VAL A 127
GLY A 143
LYS A 145
ASP A 146
THR A 171
LEU A 180
 GOL  A1300 (-4.6A)
None
None
None
None
None
None
None
None
 0.56A 5hg0B-1ufvA:
32.3		 5hg0B-1ufvA:
34.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1ufv PANTOATE-BETA-ALANIN
E LIGASE
(Thermus
thermophilus) 		5 / 12 SER A  49
GLN A 149
VAL A 169
LEU A  35
HIS A  32
 None
GOL  A1400 (-3.1A)
None
None
GOL  A1300 (-4.6A)
 1.17A 5kocB-1ufvA:
undetectable		 5kocB-1ufvA:
20.79