SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ug3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 ILE A1251
ALA A1249
LEU A1270
PHE A1279
LEU A1305
 None
 1.22A 1ddrB-1ug3A:
undetectable		 1ddrB-1ug3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 10 GLY A1299
LEU A1255
TYR A1254
HIS A1282
PHE A1279
 None
 1.48A 1jglH-1ug3A:
undetectable
1jglL-1ug3A:
undetectable		 1jglH-1ug3A:
17.96
1jglL-1ug3A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 ILE A1251
ALA A1249
LEU A1270
PHE A1279
LEU A1305
 None
 1.14A 1jolA-1ug3A:
undetectable		 1jolA-1ug3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 5 LEU A1376
TRP A1397
MET A1356
LEU A1359
 None
 1.22A 1p93D-1ug3A:
0.5		 1p93D-1ug3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 7 PHE A1360
GLU A1406
LEU A1402
THR A1364
 None
 1.14A 1rmtB-1ug3A:
undetectable		 1rmtB-1ug3A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 LEU A1532
LEU A1529
LEU A1526
ALA A1525
LEU A1516
 None
 0.93A 1s9pC-1ug3A:
undetectable		 1s9pC-1ug3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 LEU A1532
LEU A1529
LEU A1526
ALA A1525
VAL A1555
 None
 1.01A 1s9pC-1ug3A:
undetectable		 1s9pC-1ug3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 7 VAL A1504
VAL A1555
TYR A1527
ARG A1499
 None
 1.31A 1t46A-1ug3A:
undetectable		 1t46A-1ug3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 6 PHE A1561
VAL A1555
LEU A1516
ALA A1560
 None
 0.93A 2e1qA-1ug3A:
undetectable		 2e1qA-1ug3A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 6 PHE A1561
VAL A1555
LEU A1516
ALA A1560
 None
 0.88A 2e1qC-1ug3A:
0.0		 2e1qC-1ug3A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 LEU A1526
ALA A1528
ALA A1560
PHE A1546
PHE A1561
 None
 1.06A 2ejtA-1ug3A:
undetectable		 2ejtA-1ug3A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 6 TRP A1404
GLY A1401
GLY A1394
PHE A1407
 None
 1.02A 2qx6A-1ug3A:
undetectable
2qx6B-1ug3A:
undetectable		 2qx6A-1ug3A:
19.30
2qx6B-1ug3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 5 ARG A1481
MET A1484
THR A1485
LEU A1529
 None
 1.45A 3ag2J-1ug3A:
undetectable		 3ag2J-1ug3A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 11 ASN A1258
GLY A1299
ILE A1251
LEU A1255
THR A1287
 None
 1.24A 3bexC-1ug3A:
undetectable
3bexD-1ug3A:
2.3		 3bexC-1ug3A:
21.02
3bexD-1ug3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 11 LEU A1255
THR A1287
ASN A1258
GLY A1299
ILE A1251
 None
 1.25A 3bexE-1ug3A:
2.4
3bexF-1ug3A:
2.4		 3bexE-1ug3A:
21.02
3bexF-1ug3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 LEU A1255
THR A1287
ASN A1258
GLY A1299
ILE A1251
 None
 1.24A 3bf1A-1ug3A:
undetectable
3bf1B-1ug3A:
2.3		 3bf1A-1ug3A:
21.02
3bf1B-1ug3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 11 ASN A1258
GLY A1299
ILE A1251
LEU A1255
THR A1287
 None
 1.23A 3bf1E-1ug3A:
undetectable
3bf1F-1ug3A:
2.3		 3bf1E-1ug3A:
21.02
3bf1F-1ug3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		3 / 3 GLU A1262
VAL A1264
CYH A1266
 None
 0.93A 3fbxA-1ug3A:
undetectable		 3fbxA-1ug3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 ILE A1251
ALA A1249
LEU A1270
PHE A1279
LEU A1305
 None
 1.22A 3ia4D-1ug3A:
undetectable		 3ia4D-1ug3A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 ILE A1251
ALA A1249
LEU A1270
PHE A1279
LEU A1305
 None
 1.19A 3ql0A-1ug3A:
undetectable		 3ql0A-1ug3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 7 PHE A1561
VAL A1555
LEU A1516
ALA A1560
 None
 1.00A 3uniA-1ug3A:
1.1		 3uniA-1ug3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 8 GLU A1325
GLU A1322
TYR A1321
LYS A1365
 None
 0.89A 4fgzA-1ug3A:
undetectable
4fgzB-1ug3A:
undetectable		 4fgzA-1ug3A:
21.79
4fgzB-1ug3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 11 ILE A1251
ALA A1249
LEU A1270
PHE A1279
LEU A1305
 None
 1.20A 4i1nA-1ug3A:
undetectable		 4i1nA-1ug3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 ASN A1258
GLY A1299
ILE A1251
LEU A1255
THR A1287
 None
 1.21A 4o5fA-1ug3A:
undetectable
4o5fB-1ug3A:
undetectable		 4o5fA-1ug3A:
22.99
4o5fB-1ug3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 LEU A1255
THR A1287
ASN A1258
GLY A1299
ILE A1251
 None
 1.21A 4o5fA-1ug3A:
undetectable
4o5fB-1ug3A:
undetectable		 4o5fA-1ug3A:
22.99
4o5fB-1ug3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 10 CYH A1488
LEU A1505
LEU A1550
ALA A1549
LEU A1543
 None
 1.13A 4p65A-1ug3A:
undetectable
4p65B-1ug3A:
undetectable
4p65F-1ug3A:
undetectable
4p65H-1ug3A:
undetectable		 4p65A-1ug3A:
4.55
4p65B-1ug3A:
7.48
4p65F-1ug3A:
7.48
4p65H-1ug3A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 11 ILE A1251
ALA A1249
LEU A1270
PHE A1279
LEU A1305
 None
 1.17A 4qlfA-1ug3A:
undetectable		 4qlfA-1ug3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 ILE A1251
ALA A1249
LEU A1270
PHE A1279
LEU A1305
 None
 1.19A 4rgcA-1ug3A:
undetectable		 4rgcA-1ug3A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 10 GLY A1455
LEU A1448
ALA A1486
SER A1490
ALA A1491
 None
 0.88A 4wnuD-1ug3A:
undetectable		 4wnuD-1ug3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 7 ILE A1348
LEU A1306
GLY A1352
GLY A1353
 None
 0.76A 5a06A-1ug3A:
undetectable		 5a06A-1ug3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 7 ILE A1348
LEU A1306
GLY A1352
GLY A1353
 None
 0.77A 5a06B-1ug3A:
undetectable		 5a06B-1ug3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 7 ILE A1348
LEU A1306
GLY A1352
GLY A1353
 None
 0.78A 5a06C-1ug3A:
undetectable		 5a06C-1ug3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 7 ILE A1348
LEU A1306
GLY A1352
GLY A1353
 None
 0.76A 5a06E-1ug3A:
undetectable		 5a06E-1ug3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 7 ILE A1348
LEU A1306
GLY A1352
GLY A1353
 None
 0.77A 5a06F-1ug3A:
undetectable		 5a06F-1ug3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		5 / 12 LEU A1255
THR A1287
ASN A1258
GLY A1299
ILE A1251
 None
 1.20A 5b8hA-1ug3A:
undetectable
5b8hB-1ug3A:
undetectable		 5b8hA-1ug3A:
22.84
5b8hB-1ug3A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		3 / 3 LYS A1386
LEU A1542
ILE A1493
 None
 0.74A 5kc4A-1ug3A:
undetectable		 5kc4A-1ug3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		3 / 3 LEU A1341
ALA A1342
LEU A1324
 None
 0.49A 5uunB-1ug3A:
undetectable		 5uunB-1ug3A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G
(Homo
sapiens) 		4 / 5 ARG A1481
MET A1484
THR A1485
LEU A1529
 None
 1.39A 5z86J-1ug3A:
undetectable		 5z86J-1ug3A:
9.25