SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ug8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZOW_A_CLMA500_0 (MULTIDRUG TRANSPORTER MDFA)	1ug8	POLY(A)-SPECIFIC RIBONUCLEASE (Mus musculus)	5 / 11	TYR A 53 LEU A 32 LEU A 24 LEU A 34 ILE A 71	None	1.01A	4zowA-1ug8A: undetectable	4zowA-1ug8A: 12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_A_PFLA412_1 (PROTON-GATED ION CHANNEL)	1ug8	POLY(A)-SPECIFIC RIBONUCLEASE (Mus musculus)	5 / 10	ILE A 20 ILE A 73 VAL A 16 TYR A 46 ILE A 71	None	1.22A	5mzrA-1ug8A: undetectable	5mzrA-1ug8A: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_A_PFLA412_1 (PROTON-GATED ION CHANNEL)	1ug8	POLY(A)-SPECIFIC RIBONUCLEASE (Mus musculus)	5 / 10	TYR A 53 ILE A 73 VAL A 16 TYR A 46 ILE A 71	None	1.24A	5mzrA-1ug8A: undetectable	5mzrA-1ug8A: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_C_PFLC409_1 (PROTON-GATED ION CHANNEL)	1ug8	POLY(A)-SPECIFIC RIBONUCLEASE (Mus musculus)	5 / 10	ILE A 20 ILE A 73 VAL A 16 TYR A 46 ILE A 71	None	1.20A	5mzrC-1ug8A: undetectable	5mzrC-1ug8A: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_C_PFLC409_1 (PROTON-GATED ION CHANNEL)	1ug8	POLY(A)-SPECIFIC RIBONUCLEASE (Mus musculus)	5 / 10	TYR A 53 ILE A 73 VAL A 16 TYR A 46 ILE A 71	None	1.26A	5mzrC-1ug8A: undetectable	5mzrC-1ug8A: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_D_PFLD410_1 (PROTON-GATED ION CHANNEL)	1ug8	POLY(A)-SPECIFIC RIBONUCLEASE (Mus musculus)	5 / 9	ILE A 20 ILE A 73 VAL A 16 TYR A 46 ILE A 71	None	1.23A	5mzrD-1ug8A: undetectable	5mzrD-1ug8A: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_D_PFLD410_1 (PROTON-GATED ION CHANNEL)	1ug8	POLY(A)-SPECIFIC RIBONUCLEASE (Mus musculus)	5 / 9	TYR A 53 ILE A 73 VAL A 16 TYR A 46 ILE A 71	None	1.25A	5mzrD-1ug8A: undetectable	5mzrD-1ug8A: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BER_A_DVAA2_0 (E(DVA)DP(DGL)(DHI)(D PR)N(DAL)(DPR))	1ug8	POLY(A)-SPECIFIC RIBONUCLEASE (Mus musculus)	3 / 3	GLU A 33 ASP A 35 PRO A 36	None	0.79A	6berA-1ug8A: undetectable	6berA-1ug8A: 10.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4ZOW_A_CLMA500_0","MULTIDRUG TRANSPORTER MDFA","1ug8","POLY(A)-SPECIFIC RIBONUCLEASE","Mus musculus",5,"TYR A  53;LEU A  32;LEU A  24;LEU A  34;ILE A  71","None","1.01A","4zowA-1ug8A:undetectable","4zowA-1ug8A:12.63"],["5MZR_A_PFLA412_1","PROTON-GATED ION CHANNEL","1ug8","POLY(A)-SPECIFIC RIBONUCLEASE","Mus musculus",5,"ILE A  20;ILE A  73;VAL A  16;TYR A  46;ILE A  71","None","1.22A","5mzrA-1ug8A:undetectable","5mzrA-1ug8A:23.66"],["5MZR_A_PFLA412_1","PROTON-GATED ION CHANNEL","1ug8","POLY(A)-SPECIFIC RIBONUCLEASE","Mus musculus",5,"TYR A  53;ILE A  73;VAL A  16;TYR A  46;ILE A  71","None","1.24A","5mzrA-1ug8A:undetectable","5mzrA-1ug8A:23.66"],["5MZR_C_PFLC409_1","PROTON-GATED ION CHANNEL","1ug8","POLY(A)-SPECIFIC RIBONUCLEASE","Mus musculus",5,"ILE A  20;ILE A  73;VAL A  16;TYR A  46;ILE A  71","None","1.20A","5mzrC-1ug8A:undetectable","5mzrC-1ug8A:23.66"],["5MZR_C_PFLC409_1","PROTON-GATED ION CHANNEL","1ug8","POLY(A)-SPECIFIC RIBONUCLEASE","Mus musculus",5,"TYR A  53;ILE A  73;VAL A  16;TYR A  46;ILE A  71","None","1.26A","5mzrC-1ug8A:undetectable","5mzrC-1ug8A:23.66"],["5MZR_D_PFLD410_1","PROTON-GATED ION CHANNEL","1ug8","POLY(A)-SPECIFIC RIBONUCLEASE","Mus musculus",5,"ILE A  20;ILE A  73;VAL A  16;TYR A  46;ILE A  71","None","1.23A","5mzrD-1ug8A:undetectable","5mzrD-1ug8A:23.66"],["5MZR_D_PFLD410_1","PROTON-GATED ION CHANNEL","1ug8","POLY(A)-SPECIFIC RIBONUCLEASE","Mus musculus",5,"TYR A  53;ILE A  73;VAL A  16;TYR A  46;ILE A  71","None","1.25A","5mzrD-1ug8A:undetectable","5mzrD-1ug8A:23.66"],["6BER_A_DVAA2_0","E(DVA)DP(DGL)(DHI)(DPR)N(DAL)(DPR)","1ug8","POLY(A)-SPECIFIC RIBONUCLEASE","Mus musculus",3,"GLU A  33;ASP A  35;PRO A  36","None","0.79A","6berA-1ug8A:undetectable","6berA-1ug8A:10.91"]]