SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ugp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NN4_A_SC2A1016_1 (LYSOSOMAL ALPHA-GLUCOSIDASE)	1ugp	NITRILE HYDRATASE BETA SUBUNIT (Pseudonocardia thermophila)	4 / 4	HIS B 78 GLY B 80 ARG B 82 THR B 83	None	1.35A	5nn4A-1ugpB: undetectable	5nn4A-1ugpB: 12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_A_ACTA303_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	1ugp	NITRILE HYDRATASE BETA SUBUNIT (Pseudonocardia thermophila)	3 / 3	GLU B 224 TYR B 222 ARG B 158	None	0.71A	5uunA-1ugpB: undetectable	5uunA-1ugpB: 22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_B_ACTB305_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	1ugp	NITRILE HYDRATASE BETA SUBUNIT (Pseudonocardia thermophila)	3 / 3	GLU B 224 TYR B 222 ARG B 158	None	0.67A	5uunB-1ugpB: undetectable	5uunB-1ugpB: 22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UXD_A_ZITA501_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E MPHH)	1ugp	NITRILE HYDRATASE BETA SUBUNIT (Pseudonocardia thermophila)	4 / 7	PHE B 37 ALA B 122 GLY B 125 TYR B 124	None	0.98A	5uxdA-1ugpB: undetectable	5uxdA-1ugpB: 21.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["5NN4_A_SC2A1016_1","LYSOSOMAL ALPHA-GLUCOSIDASE","1ugp","NITRILE HYDRATASE BETA SUBUNIT","Pseudonocardia thermophila",4,"HIS B  78;GLY B  80;ARG B  82;THR B  83","None","1.35A","5nn4A-1ugpB:undetectable","5nn4A-1ugpB:12.53"],["5UUN_A_ACTA303_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","1ugp","NITRILE HYDRATASE BETA SUBUNIT","Pseudonocardia thermophila",3,"GLU B 224;TYR B 222;ARG B 158","None","0.71A","5uunA-1ugpB:undetectable","5uunA-1ugpB:22.68"],["5UUN_B_ACTB305_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","1ugp","NITRILE HYDRATASE BETA SUBUNIT","Pseudonocardia thermophila",3,"GLU B 224;TYR B 222;ARG B 158","None","0.67A","5uunB-1ugpB:undetectable","5uunB-1ugpB:22.68"],["5UXD_A_ZITA501_1","MACROLIDE 2'-PHOSPHOTRANSFERASE MPHH","1ugp","NITRILE HYDRATASE BETA SUBUNIT","Pseudonocardia thermophila",4,"PHE B  37;ALA B 122;GLY B 125;TYR B 124","None","0.98A","5uxdA-1ugpB:undetectable","5uxdA-1ugpB:21.18"]]