SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1uhg OVALBUMIN
(Gallus
gallus) 		5 / 12 ILE A  86
SER A 240
MET A 239
PHE A  99
ILE A 178
 None
 1.22A 1xotA-1uhgA:
undetectable		 1xotA-1uhgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1uhg OVALBUMIN
(Gallus
gallus) 		4 / 5 LEU A 321
LEU A 312
LEU A  43
MET A 172
 DSN  A 320 ( 4.6A)
None
None
None
 1.11A 2oaxF-1uhgA:
undetectable		 2oaxF-1uhgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1uhg OVALBUMIN
(Gallus
gallus) 		4 / 7 ILE A  53
ARG A  50
PHE A  65
GLU A  70
 None
 0.98A 2qebA-1uhgA:
undetectable		 2qebA-1uhgA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1uhg OVALBUMIN
(Gallus
gallus) 		4 / 7 ILE A  53
ARG A  50
PHE A  65
GLU A  70
 None
 0.97A 2qebB-1uhgA:
undetectable		 2qebB-1uhgA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1uhg OVALBUMIN
(Gallus
gallus) 		5 / 11 ALA A 375
LEU A  87
ILE A  90
ILE A 178
THR A 373
 None
SO4  A 401 ( 4.9A)
None
None
None
 0.81A 2w9sA-1uhgA:
undetectable		 2w9sA-1uhgA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 1uhg OVALBUMIN
(Gallus
gallus) 		3 / 3 CYH A  11
PHE A  15
PHE A  12
 None
 1.03A 3cr5X-1uhgA:
undetectable		 3cr5X-1uhgA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 1uhg OVALBUMIN
(Gallus
gallus) 		4 / 6 VAL A 296
VAL A  56
PHE A  10
GLU A  17
 None
 1.49A 3n61A-1uhgA:
0.0
3n61B-1uhgA:
0.0		 3n61A-1uhgA:
21.31
3n61B-1uhgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1uhg OVALBUMIN
(Gallus
gallus) 		6 / 11 VAL A 383
PHE A  15
ASN A  26
ILE A  27
GLY A 380
LEU A 252
 None
 1.32A 3t3rA-1uhgA:
0.0		 3t3rA-1uhgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1uhg OVALBUMIN
(Gallus
gallus) 		5 / 9 VAL A 383
PHE A  15
ASN A  26
ILE A  27
GLY A 380
 None
 1.30A 3t3rB-1uhgA:
0.0		 3t3rB-1uhgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1uhg OVALBUMIN
(Gallus
gallus) 		5 / 9 VAL A 383
PHE A  15
ASN A  26
ILE A  27
GLY A 380
 None
 1.27A 3t3rC-1uhgA:
0.0		 3t3rC-1uhgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1uhg OVALBUMIN
(Gallus
gallus) 		5 / 8 GLY A   4
SER A   7
MET A   8
ILE A  86
LEU A 377
 None
 1.36A 3v1nA-1uhgA:
undetectable		 3v1nA-1uhgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 1uhg OVALBUMIN
(Gallus
gallus) 		5 / 12 LEU A 183
PHE A 234
LEU A 232
LEU A 230
ALA A 360
 None
 1.26A 4rtbA-1uhgA:
undetectable		 4rtbA-1uhgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1uhg OVALBUMIN
(Gallus
gallus) 		5 / 12 ALA A  39
ASP A  60
PHE A  59
GLY A  66
GLU A  70
 None
 1.34A 5hfjA-1uhgA:
undetectable		 5hfjA-1uhgA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1uhg OVALBUMIN
(Gallus
gallus) 		5 / 12 ALA A  39
ASP A  60
PHE A  59
GLY A  66
GLU A  70
 None
 1.32A 5hfjE-1uhgA:
undetectable		 5hfjE-1uhgA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uhg OVALBUMIN
(Gallus
gallus) 		3 / 3 SER A 307
LEU A 105
MET A 172
 None
 0.72A 5ikrB-1uhgA:
undetectable		 5ikrB-1uhgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1uhg OVALBUMIN
(Gallus
gallus) 		3 / 3 ARG A 359
PHE A 366
LEU A 230
 None
 0.67A 5veuA-1uhgA:
undetectable		 5veuA-1uhgA:
20.96