SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uhw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1uhw PLECKSTRIN
(Mus
musculus) 		4 / 6 PHE A  91
ASN A  89
ILE A  62
GLY A  59
 None
 0.90A 1oniA-1uhwA:
undetectable
1oniB-1uhwA:
undetectable		 1oniA-1uhwA:
22.15
1oniB-1uhwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1uhw PLECKSTRIN
(Mus
musculus) 		4 / 6 PHE A  91
ASN A  89
ILE A  62
GLY A  59
 None
 0.88A 1oniD-1uhwA:
undetectable
1oniF-1uhwA:
undetectable		 1oniD-1uhwA:
22.15
1oniF-1uhwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1uhw PLECKSTRIN
(Mus
musculus) 		4 / 7 ILE A  62
GLY A  59
PHE A  91
ASN A  89
 None
 0.83A 1oniG-1uhwA:
undetectable
1oniI-1uhwA:
undetectable		 1oniG-1uhwA:
22.15
1oniI-1uhwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1uhw PLECKSTRIN
(Mus
musculus) 		4 / 6 SER A   5
LEU A  52
ALA A  10
LEU A  13
 None
 0.89A 3kk6B-1uhwA:
undetectable		 3kk6B-1uhwA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 1uhw PLECKSTRIN
(Mus
musculus) 		4 / 6 ILE A  44
ILE A  22
PHE A  91
LEU A  66
 None
 0.89A 4m51A-1uhwA:
undetectable		 4m51A-1uhwA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1uhw PLECKSTRIN
(Mus
musculus) 		5 / 11 GLY A  42
GLY A  40
ILE A  44
GLY A  21
PHE A 101
 None
 1.13A 4qoiA-1uhwA:
undetectable
4qoiB-1uhwA:
undetectable		 4qoiA-1uhwA:
18.34
4qoiB-1uhwA:
18.34