SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 7 LEU A 376
TYR A 369
THR A 380
ASN A 410
 None
 1.11A 1afsA-1uikA:
undetectable		 1afsA-1uikA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 7 LEU A 376
TYR A 369
THR A 380
ASN A 410
 None
 1.11A 1afsB-1uikA:
undetectable		 1afsB-1uikA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 12 GLY A 482
ASN A 488
PHE A 478
LEU A 417
PHE A 532
 None
 1.33A 1pj7A-1uikA:
undetectable		 1pj7A-1uikA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 6 LEU A 181
LEU A 263
LEU A 171
ILE A 265
 None
 0.99A 1z95A-1uikA:
undetectable		 1z95A-1uikA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 8 LEU A 387
PHE A 360
LEU A 394
PHE A 481
 None
 0.95A 2eilP-1uikA:
undetectable
2eilW-1uikA:
undetectable		 2eilP-1uikA:
20.00
2eilW-1uikA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 12 ILE A 419
PHE A 481
GLY A 482
ASN A 410
VAL A 396
 None
 1.48A 2nyrB-1uikA:
undetectable		 2nyrB-1uikA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		3 / 3 ASN A 420
ASN A 477
ARG A 363
 None
 0.89A 2rlcA-1uikA:
undetectable		 2rlcA-1uikA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 11 ARG A 363
LEU A 210
PHE A 481
ALA A 480
LEU A 214
 None
 1.25A 2v0mA-1uikA:
undetectable		 2v0mA-1uikA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 11 ARG A 363
LEU A 210
PHE A 481
ALA A 480
LEU A 214
 None
 1.36A 2v0mD-1uikA:
undetectable		 2v0mD-1uikA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		3 / 3 PHE A 150
ASN A 148
PHE A 460
 None
 1.02A 2zbuD-1uikA:
undetectable		 2zbuD-1uikA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 10 LEU A 263
ALA A 480
PHE A 481
GLY A 482
ILE A 483
 None
 1.44A 3qpsA-1uikA:
undetectable		 3qpsA-1uikA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		3 / 4 SER A 178
GLY A 430
GLU A 446
 None
 0.63A 3raeA-1uikA:
undetectable
3raeC-1uikA:
undetectable		 3raeA-1uikA:
24.22
3raeC-1uikA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		3 / 3 ASN A 488
ALA A 485
LYS A 412
 None
 0.94A 3runA-1uikA:
undetectable		 3runA-1uikA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		3 / 3 PHE A 150
SER A 178
GLN A 180
 None
 0.97A 3smtA-1uikA:
undetectable		 3smtA-1uikA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 10 THR A 262
PHE A 273
LEU A 200
VAL A 329
PHE A 277
 None
 1.49A 3u9fK-1uikA:
undetectable		 3u9fK-1uikA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 12 LEU A 184
ILE A 189
TYR A 187
ALA A 485
VAL A 212
 None
 1.16A 3vw1D-1uikA:
undetectable		 3vw1D-1uikA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 7 LEU A 199
THR A 246
THR A 221
VAL A 223
 None
 0.94A 4ik7A-1uikA:
undetectable		 4ik7A-1uikA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		3 / 4 SER A 178
GLY A 430
GLU A 446
 None
 0.63A 4juoA-1uikA:
undetectable
4juoC-1uikA:
undetectable		 4juoA-1uikA:
24.22
4juoC-1uikA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		3 / 3 ASN A 225
ASP A 227
ASP A 357
 None
 0.86A 4obwD-1uikA:
undetectable		 4obwD-1uikA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 7 LEU A 181
LEU A 263
LEU A 171
ILE A 265
 None
 0.90A 4okwA-1uikA:
undetectable		 4okwA-1uikA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 12 GLY A 166
TYR A 165
SER A 328
GLN A 457
HIS A 167
 None
 1.33A 4xueB-1uikA:
undetectable		 4xueB-1uikA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 6 ILE A 459
PHE A 157
ILE A 261
GLU A 191
 None
 1.22A 4zzcA-1uikA:
undetectable
4zzcB-1uikA:
undetectable		 4zzcA-1uikA:
23.00
4zzcB-1uikA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 12 VAL A 397
ASP A 398
ALA A 480
ARG A 363
GLY A 236
 None
 1.16A 5m5cB-1uikA:
undetectable		 5m5cB-1uikA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 7 LEU A 387
PHE A 360
LEU A 394
PHE A 481
 None
 0.94A 5z84C-1uikA:
undetectable
5z84J-1uikA:
undetectable		 5z84C-1uikA:
20.00
5z84J-1uikA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 10 TYR A 247
HIS A 203
LEU A 190
TYR A 209
VAL A 168
 None
 1.32A 5zbdA-1uikA:
undetectable		 5zbdA-1uikA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CB4_A_BEZA501_0
(CANAVALIN)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 8 HIS A 408
ASN A 410
VAL A 415
ILE A 462
 None
 0.33A 6cb4A-1uikA:
46.6		 6cb4A-1uikA:
53.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CB4_A_BEZA501_0
(CANAVALIN)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 8 HIS A 408
VAL A 415
LEU A 417
ILE A 462
ARG A 490
 None
 0.67A 6cb4A-1uikA:
46.6		 6cb4A-1uikA:
53.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		3 / 3 LEU A 233
GLY A 236
PHE A 481
 None
 0.60A 6exiC-1uikA:
undetectable		 6exiC-1uikA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		4 / 7 TYR A 247
HIS A 203
TYR A 209
VAL A 168
 None
 1.29A 6g2pA-1uikA:
undetectable		 6g2pA-1uikA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ
(Glycine
max) 		5 / 10 TYR A 247
HIS A 203
LEU A 190
TYR A 209
VAL A 168
 None
 1.35A 6g2pB-1uikA:
0.0		 6g2pB-1uikA:
21.87