SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		4 / 7 HIS A 197
THR A 108
TRP A  90
TYR A 178
 NRQ  A  63 (-3.6A)
None
NRQ  A  63 ( 4.1A)
None
 1.33A 1afsB-1uisA:
undetectable		 1afsB-1uisA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		4 / 7 GLY A 156
GLY A 152
PHE A  79
PHE A  80
 None
 0.97A 2qwxA-1uisA:
undetectable
2qwxB-1uisA:
undetectable		 2qwxA-1uisA:
20.38
2qwxB-1uisA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		4 / 7 THR A 122
VAL A 101
THR A 103
VAL A  93
 None
 0.35A 3em0B-1uisA:
undetectable		 3em0B-1uisA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		4 / 5 GLY A  37
ALA A 217
PHE A  69
GLU A 215
 None
ACY  A1001 (-3.6A)
None
ACY  A1001 (-3.2A)
 0.88A 4m93B-1uisA:
undetectable
4m93C-1uisA:
undetectable		 4m93B-1uisA:
21.48
4m93C-1uisA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		3 / 3 ASN A 143
SER A 158
ARG A  92
 NRQ  A  63 ( 3.1A)
NRQ  A  63 ( 2.4A)
NRQ  A  63 ( 3.1A)
 0.94A 5b2qA-1uisA:
undetectable		 5b2qA-1uisA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		4 / 5 LEU A 147
TYR A 157
LEU A 154
TYR A 178
 None
 1.21A 5ki6A-1uisA:
undetectable		 5ki6A-1uisA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		4 / 4 LEU A  58
ARG A  92
ILE A  57
PHE A 102
 None
NRQ  A  63 ( 3.1A)
None
None
 1.33A 5kirB-1uisA:
undetectable		 5kirB-1uisA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		4 / 6 TYR A  96
PHE A 102
THR A  94
GLY A  99
 None
 1.22A 5mraA-1uisA:
undetectable
5mraB-1uisA:
undetectable		 5mraA-1uisA:
21.24
5mraB-1uisA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		4 / 6 LYS A  74
VAL A 195
LYS A 220
ILE A  70
 None
None
None
ACY  A1001 (-4.8A)
 1.41A 5q1sA-1uisA:
0.1		 5q1sA-1uisA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		4 / 6 PHE A 126
PRO A 127
GLY A 130
ASN A 129
 None
 0.89A 5x24A-1uisA:
undetectable		 5x24A-1uisA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1uis RED FLUORESCENT
PROTEIN FP611
(Entacmaea
quadricolor) 		5 / 11 ILE A  70
TYR A 178
LEU A 154
GLY A 156
SER A 158
 ACY  A1001 (-4.8A)
None
None
None
NRQ  A  63 ( 2.4A)
 1.05A 6ieyA-1uisA:
undetectable
6ieyB-1uisA:
undetectable		 6ieyA-1uisA:
21.34
6ieyB-1uisA:
21.34