SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uiy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 10 LEU A  14
ASN A 102
VAL A 101
GLY A 103
LEU A  49
 None
 1.32A 1fkoA-1uiyA:
undetectable		 1fkoA-1uiyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 ASN A  76
PHE A 136
VAL A  68
 None
GOL  A 400 ( 4.1A)
None
 0.73A 1kijA-1uiyA:
undetectable		 1kijA-1uiyA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 ASP A  41
ASP A  37
LYS A  95
 None
 1.17A 1lqtB-1uiyA:
undetectable		 1lqtB-1uiyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 11 ALA A 148
ARG A 162
GLU A 168
ALA A 169
LEU A 172
 None
 1.32A 1mjlA-1uiyA:
undetectable
1mjlB-1uiyA:
undetectable		 1mjlA-1uiyA:
18.83
1mjlB-1uiyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 THR A  97
LEU A  49
VAL A  12
 None
 0.36A 1mz9E-1uiyA:
undetectable		 1mz9E-1uiyA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 9 VAL A 101
LEU A  23
VAL A 106
GLY A 109
ALA A 110
 None
 1.18A 1pxxB-1uiyA:
undetectable		 1pxxB-1uiyA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 10 VAL A 101
LEU A  23
VAL A 106
GLY A 109
ALA A 110
 None
 1.19A 1pxxD-1uiyA:
undetectable		 1pxxD-1uiyA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 LEU A  49
ILE A 144
VAL A 119
LEU A 127
LEU A 174
 None
 1.01A 1s19A-1uiyA:
undetectable		 1s19A-1uiyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		5 / 12 VAL A 101
VAL A 106
GLY A 109
ALA A 110
LEU A 114
 None
 1.03A 3hs6A-1uiyA:
0.0		 3hs6A-1uiyA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 ASP A  36
ASP A  37
VAL A   4
LEU A  31
 None
 0.95A 4f8hA-1uiyA:
undetectable
4f8hB-1uiyA:
undetectable		 4f8hA-1uiyA:
21.45
4f8hB-1uiyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 ASP A  36
ASP A  37
VAL A   4
LEU A  31
 None
 0.90A 4f8hB-1uiyA:
undetectable
4f8hC-1uiyA:
undetectable		 4f8hB-1uiyA:
21.45
4f8hC-1uiyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 ASP A  36
ASP A  37
VAL A   4
LEU A  31
 None
 0.94A 4f8hC-1uiyA:
undetectable
4f8hD-1uiyA:
undetectable		 4f8hC-1uiyA:
21.45
4f8hD-1uiyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 ASP A  36
ASP A  37
VAL A   4
LEU A  31
 None
 0.94A 4f8hD-1uiyA:
undetectable
4f8hE-1uiyA:
undetectable		 4f8hD-1uiyA:
21.45
4f8hE-1uiyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 VAL A   4
LEU A  31
ASP A  36
ASP A  37
 None
 0.92A 4f8hA-1uiyA:
undetectable
4f8hE-1uiyA:
undetectable		 4f8hA-1uiyA:
21.45
4f8hE-1uiyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 VAL A 164
LEU A 172
LEU A 174
TYR A 129
 None
 0.91A 4lzrA-1uiyA:
undetectable		 4lzrA-1uiyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 PHE A  56
VAL A   2
SER A  57
GLY A  51
 None
 0.90A 4m48A-1uiyA:
undetectable		 4m48A-1uiyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 ALA A 100
VAL A 120
GLU A 186
LYS A 189
 None
 0.88A 4zbqA-1uiyA:
3.5		 4zbqA-1uiyA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 7 VAL A 101
LEU A  23
GLY A 109
ALA A 110
 None
 0.90A 5f1aB-1uiyA:
undetectable		 5f1aB-1uiyA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 7 ASN A 102
VAL A 101
ALA A 113
GLY A 109
 None
 0.89A 5fpdB-1uiyA:
undetectable		 5fpdB-1uiyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 8 GLN A   3
ALA A  34
GLN A  33
SER A  30
 None
 1.07A 5km8A-1uiyA:
undetectable
5km8B-1uiyA:
undetectable		 5km8A-1uiyA:
21.07
5km8B-1uiyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 VAL A 120
ARG A  45
PRO A  96
 None
 0.80A 5koxA-1uiyA:
undetectable		 5koxA-1uiyA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 4 VAL A   2
LEU A  29
ASN A  21
ASP A  16
 None
 1.31A 5vcyA-1uiyA:
undetectable		 5vcyA-1uiyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 4 VAL A   2
LEU A  32
ASN A  21
ASP A  16
 None
 0.98A 5vcyA-1uiyA:
undetectable		 5vcyA-1uiyA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 GLY A 128
VAL A 119
MET A 121
 None
 0.63A 5ycpA-1uiyA:
undetectable		 5ycpA-1uiyA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		4 / 7 LEU A  86
LEU A  32
ALA A  34
THR A  97
 None
 0.73A 6a7jA-1uiyA:
undetectable		 6a7jA-1uiyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 1uiy ENOYL-COA HYDRATASE
(Thermus
thermophilus) 		3 / 3 TYR A 129
ALA A 148
LEU A 174
 None
 0.69A 6d9kF-1uiyA:
undetectable		 6d9kF-1uiyA:
17.02