SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uj2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		5 / 12 ALA A 139
SER A  34
GLU A 135
ARG A 174
ASP A  84
 None
MG  A2303 ( 2.3A)
MG  A2303 ( 4.6A)
C5P  A2301 (-3.9A)
C5P  A2301 (-2.8A)
 1.12A 1dy4A-1uj2A:
undetectable		 1dy4A-1uj2A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		5 / 10 LEU A 133
VAL A  25
GLY A  24
GLY A 136
GLN A  61
 None
 1.26A 2wd9C-1uj2A:
undetectable		 2wd9C-1uj2A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		5 / 10 VAL A  25
ALA A 139
ILE A  94
ILE A 109
PRO A 110
 None
 1.25A 3clbD-1uj2A:
2.7		 3clbD-1uj2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A  43
ALA A  38
ILE A  40
SER A  35
ARG A 165
 None
None
None
ADP  A2302 (-4.5A)
ADP  A2302 (-3.6A)
 1.33A 3gyqA-1uj2A:
undetectable
3gyqB-1uj2A:
undetectable		 3gyqA-1uj2A:
24.04
3gyqB-1uj2A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		5 / 10 VAL A  25
ALA A 139
ILE A  94
ILE A 109
PRO A 110
 None
 1.20A 3hbbD-1uj2A:
2.6		 3hbbD-1uj2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		5 / 10 VAL A  41
ALA A 129
VAL A 126
GLN A  46
ILE A  58
 None
 1.43A 3retA-1uj2A:
undetectable
3retB-1uj2A:
1.4		 3retA-1uj2A:
15.16
3retB-1uj2A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		3 / 3 LEU A  44
LEU A 229
ARG A  52
 None
 0.64A 5hnzB-1uj2A:
undetectable		 5hnzB-1uj2A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 178
ILE A 181
GLY A 175
LEU A 168
VAL A 167
 None
 0.97A 5twjA-1uj2A:
undetectable		 5twjA-1uj2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		5 / 10 LEU A 178
ILE A 181
GLY A 175
LEU A 168
VAL A 167
 None
 0.96A 5twjB-1uj2A:
undetectable		 5twjB-1uj2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		4 / 7 GLY A 211
SER A  31
GLY A  32
VAL A  36
 None
ADP  A2302 (-3.2A)
ADP  A2302 (-3.3A)
None
 0.77A 6ekzA-1uj2A:
undetectable		 6ekzA-1uj2A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1uj2 URIDINE-CYTIDINE
KINASE 2
(Homo
sapiens) 		4 / 8 GLY A  32
SER A  35
ALA A  38
LYS A  39
 ADP  A2302 (-3.3A)
ADP  A2302 (-4.5A)
None
None
 0.70A 6hu9H-1uj2A:
undetectable
6hu9e-1uj2A:
undetectable		 6hu9H-1uj2A:
21.74
6hu9e-1uj2A:
21.51