SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 11 GLU A  90
LEU A 131
ALA A  96
PHE A 207
GLY A 209
 None
 1.34A 1cmaA-1uj4A:
undetectable
1cmaB-1uj4A:
undetectable		 1cmaA-1uj4A:
18.58
1cmaB-1uj4A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 7 ALA A  37
GLU A  40
LEU A  41
VAL A  26
 None
 0.71A 1hk2A-1uj4A:
undetectable		 1hk2A-1uj4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 GLY A 132
GLY A 134
LYS A 126
ILE A  91
LEU A  97
 None
 0.99A 1v2xA-1uj4A:
undetectable		 1v2xA-1uj4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 7 ARG A  44
LEU A  50
PRO A  57
VAL A  26
 None
 1.36A 2hrcA-1uj4A:
undetectable		 2hrcA-1uj4A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 GLY A  31
GLY A  27
LEU A  76
VAL A  81
ASP A  86
 None
 1.00A 2wa2B-1uj4A:
undetectable		 2wa2B-1uj4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		3 / 3 SER A  59
GLY A  29
GLY A  31
 None
 0.49A 3bogA-1uj4A:
undetectable
3bogC-1uj4A:
undetectable		 3bogA-1uj4A:
undetectable
3bogC-1uj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 10 ALA A  84
VAL A 111
GLY A  55
VAL A  54
PRO A  77
 None
 0.94A 3oxwD-1uj4A:
undetectable		 3oxwD-1uj4A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 5 SER A  59
GLU A 108
THR A  62
ASP A  86
 None
CL  A 301 (-3.1A)
None
None
 1.20A 3zs3A-1uj4A:
undetectable		 3zs3A-1uj4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 8 ARG A 213
GLY A  87
ALA A  88
ASP A  89
 None
 0.88A 4eyrB-1uj4A:
undetectable		 4eyrB-1uj4A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A  41
LEU A  73
VAL A  25
MET A  24
THR A  58
 None
 1.36A 4okbA-1uj4A:
undetectable		 4okbA-1uj4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 6 ASP A  86
ALA A 104
THR A  58
THR A  62
 None
CL  A 301 (-3.9A)
None
None
 1.37A 4w5qA-1uj4A:
1.4		 4w5qA-1uj4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 6 ASP A  86
ALA A 104
THR A  58
THR A  62
 None
CL  A 301 (-3.9A)
None
None
 1.33A 4w5rA-1uj4A:
0.0		 4w5rA-1uj4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 6 ASP A  86
ALA A 104
THR A  58
THR A  62
 None
CL  A 301 (-3.9A)
None
None
 1.29A 4w5tA-1uj4A:
undetectable		 4w5tA-1uj4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 6 ASP A  86
ALA A 104
THR A  58
THR A  62
 None
CL  A 301 (-3.9A)
None
None
 1.32A 4z4cA-1uj4A:
undetectable		 4z4cA-1uj4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		4 / 6 ASP A  86
ALA A 104
THR A  58
THR A  62
 None
CL  A 301 (-3.9A)
None
None
 1.34A 4z4iA-1uj4A:
undetectable		 4z4iA-1uj4A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 ALA A 178
PRO A 137
GLY A 205
LEU A 206
ALA A 151
 None
 1.14A 5c0oE-1uj4A:
3.1		 5c0oE-1uj4A:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 ALA A 178
PRO A 137
GLY A 205
LEU A 206
LEU A 155
 None
 0.97A 5c0oG-1uj4A:
4.0		 5c0oG-1uj4A:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A  39
LEU A  83
ASP A  86
GLY A  29
ILE A 121
 None
 1.17A 5j7wC-1uj4A:
undetectable		 5j7wC-1uj4A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 GLY A  27
VAL A  53
VAL A  38
ALA A  37
LEU A  41
 None
 1.05A 5kocA-1uj4A:
3.1		 5kocA-1uj4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 PHE A 207
VAL A 208
ALA A  88
ILE A 121
ALA A 122
 None
 0.97A 5n0tB-1uj4A:
undetectable		 5n0tB-1uj4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 ASP A 123
LEU A  65
LEU A  39
THR A  62
GLY A  87
 None
 1.13A 6b0lB-1uj4A:
undetectable		 6b0lB-1uj4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE
(Thermus
thermophilus) 		5 / 12 LEU A  39
LEU A  83
ASP A  86
GLY A  29
ILE A 121
 None
 1.16A 6qxsD-1uj4A:
undetectable		 6qxsD-1uj4A:
22.74