SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ujn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 5 GLY A  93
LEU A  96
THR A  97
VAL A  39
 None
 0.92A 1ekjF-1ujnA:
3.0
1ekjG-1ujnA:
3.2		 1ekjF-1ujnA:
21.91
1ekjG-1ujnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 199
PHE A 202
ALA A 201
LEU A 156
 None
 0.91A 1ukbA-1ujnA:
3.3		 1ukbA-1ujnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A 170
VAL A 251
LEU A 186
LEU A 255
HIS A 177
 None
 1.13A 1ya4B-1ujnA:
undetectable		 1ya4B-1ujnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 4 LEU A 295
PRO A 296
LEU A 294
ARG A 338
 None
 1.19A 2hrcA-1ujnA:
undetectable		 2hrcA-1ujnA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 4 LEU A 295
PRO A 296
LEU A 294
ARG A 338
 None
 1.34A 3hcoB-1ujnA:
1.9		 3hcoB-1ujnA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 11 LEU A 298
LEU A 295
LEU A 330
GLY A 254
LEU A 237
 None
 1.34A 3hm1B-1ujnA:
undetectable		 3hm1B-1ujnA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 7 TYR A 253
GLU A 340
TRP A 337
LEU A 237
 None
 1.38A 3k8mA-1ujnA:
undetectable		 3k8mA-1ujnA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 277
LEU A 341
PRO A 283
LEU A 344
 None
 1.09A 3q1eA-1ujnA:
0.0
3q1eC-1ujnA:
0.0		 3q1eA-1ujnA:
15.80
3q1eC-1ujnA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 341
PRO A 283
LEU A 344
LEU A 277
 None
 1.10A 3q1eA-1ujnA:
0.0
3q1eC-1ujnA:
0.0		 3q1eA-1ujnA:
15.80
3q1eC-1ujnA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 243
GLU A  62
ASN A 141
 None
 0.84A 4bupB-1ujnA:
undetectable		 4bupB-1ujnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 247
GLU A  62
ASN A 141
 None
 0.77A 4bupB-1ujnA:
undetectable		 4bupB-1ujnA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 9 LEU A 171
LEU A 164
PHE A 167
THR A 120
LEU A 203
 None
 1.30A 4ltwA-1ujnA:
undetectable		 4ltwA-1ujnA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 277
HIS A 247
HIS A 231
GLU A 173
 None
 1.12A 4pahA-1ujnA:
undetectable		 4pahA-1ujnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 281
HIS A 247
HIS A 231
GLU A 173
 None
 0.87A 4pahA-1ujnA:
undetectable		 4pahA-1ujnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		6 / 12 ALA A 208
VAL A 209
LEU A 255
ARG A 276
ALA A 174
LEU A 187
 None
 1.27A 4qrcA-1ujnA:
undetectable		 4qrcA-1ujnA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 4 ALA A  43
VAL A  90
GLY A  93
THR A 118
 None
 0.86A 4ubeA-1ujnA:
undetectable		 4ubeA-1ujnA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A  99
LEU A  74
VAL A  73
PHE A 102
 None
 1.22A 4uswA-1ujnA:
undetectable		 4uswA-1ujnA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 11 LEU A 192
LEU A 171
GLU A 200
ALA A 204
LEU A 203
 None
 1.06A 4wg0B-1ujnA:
undetectable
4wg0C-1ujnA:
undetectable
4wg0D-1ujnA:
undetectable		 4wg0B-1ujnA:
3.62
4wg0C-1ujnA:
3.62
4wg0D-1ujnA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 11 LEU A 192
LEU A 171
GLU A 200
ALA A 204
LEU A 203
 None
 1.06A 4wg0D-1ujnA:
undetectable
4wg0E-1ujnA:
undetectable
4wg0F-1ujnA:
undetectable		 4wg0D-1ujnA:
3.62
4wg0E-1ujnA:
3.62
4wg0F-1ujnA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 11 LEU A 192
LEU A 171
GLU A 200
ALA A 204
LEU A 203
 None
 1.03A 4wg0F-1ujnA:
undetectable
4wg0G-1ujnA:
undetectable
4wg0H-1ujnA:
undetectable		 4wg0F-1ujnA:
3.62
4wg0G-1ujnA:
3.62
4wg0H-1ujnA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 11 GLU A 200
ALA A 204
LEU A 203
LEU A 192
LEU A 171
 None
 1.06A 4wg0G-1ujnA:
undetectable
4wg0H-1ujnA:
undetectable
4wg0I-1ujnA:
undetectable		 4wg0G-1ujnA:
3.62
4wg0H-1ujnA:
3.62
4wg0I-1ujnA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 PRO A 273
GLY A 178
ASP A 183
LEU A 271
ALA A 259
 None
 1.15A 5h5fA-1ujnA:
undetectable		 5h5fA-1ujnA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLU A 173
LEU A 179
LYS A 176
GLY A 230
LEU A 256
 None
 1.24A 5kbwA-1ujnA:
undetectable		 5kbwA-1ujnA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 PHE A 102
ASP A  98
LEU A 114
 None
 0.78A 5uhcC-1ujnA:
undetectable		 5uhcC-1ujnA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 243
GLU A  62
ASN A 141
 None
 0.87A 5wbvA-1ujnA:
undetectable		 5wbvA-1ujnA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 247
GLU A  62
ASN A 141
 None
 0.75A 5wbvA-1ujnA:
undetectable		 5wbvA-1ujnA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 243
GLU A  62
ASN A 141
 None
 0.86A 5wbvB-1ujnA:
undetectable		 5wbvB-1ujnA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 247
GLU A  62
ASN A 141
 None
 0.75A 5wbvB-1ujnA:
undetectable		 5wbvB-1ujnA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 277
HIS A 247
HIS A 231
GLU A 173
 None
 1.07A 6pahA-1ujnA:
undetectable		 6pahA-1ujnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 281
HIS A 247
HIS A 231
GLU A 173
 None
 0.86A 6pahA-1ujnA:
undetectable		 6pahA-1ujnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ujn DEHYDROQUINATE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 ASP A 183
LEU A 186
ARG A 198
 None
 0.74A 7dfrA-1ujnA:
2.2		 7dfrA-1ujnA:
19.25