SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ukm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A  42
TRP A  25
 None
 1.25A 1c4dC-1ukmA:
undetectable
1c4dD-1ukmA:
undetectable		 1c4dC-1ukmA:
9.91
1c4dD-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A 128
TRP A  25
 None
 1.34A 1c4dC-1ukmA:
undetectable
1c4dD-1ukmA:
undetectable		 1c4dC-1ukmA:
9.91
1c4dD-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 1ukm EMS16 B CHAIN
(Echis
multisquamatus) 		3 / 3 TRP B  64
VAL B 119
TRP B  22
 None
 1.30A 1c4dC-1ukmB:
undetectable
1c4dD-1ukmB:
undetectable		 1c4dC-1ukmB:
23.33
1c4dD-1ukmB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 1ukm EMS16 A CHAIN
EMS16 B CHAIN
(Echis
multisquamatus;
Echis
multisquamatus) 		4 / 5 GLU B  77
ALA B  82
SER A  43
HIS A  40
 None
 1.32A 1errA-1ukmB:
undetectable
1errB-1ukmB:
undetectable		 1errA-1ukmB:
16.94
1errB-1ukmB:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1ukm EMS16 A CHAIN
EMS16 B CHAIN
(Echis
multisquamatus;
Echis
multisquamatus) 		4 / 6 TRP A 116
LEU A  72
TRP B  76
PHE B  84
 None
 1.28A 1ru9H-1ukmA:
undetectable
1ru9L-1ukmA:
undetectable		 1ru9H-1ukmA:
19.10
1ru9L-1ukmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1ukm EMS16 A CHAIN
EMS16 B CHAIN
(Echis
multisquamatus;
Echis
multisquamatus) 		4 / 6 TRP A 116
LEU A  72
TRP B  76
PHE B  84
 None
 1.38A 1rukH-1ukmA:
undetectable
1rukL-1ukmA:
undetectable		 1rukH-1ukmA:
19.10
1rukL-1ukmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 1ukm EMS16 A CHAIN
EMS16 B CHAIN
(Echis
multisquamatus) 		5 / 11 PRO B  70
LYS A 102
GLN A 105
GLY A  71
GLU A  29
 None
GOL  B1303 (-3.0A)
None
None
None
 1.03A 2h9tH-1ukmB:
undetectable		 2h9tH-1ukmB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		5 / 10 ALA A  54
VAL A 128
VAL A  68
ILE A  70
VAL A  42
 None
 1.04A 2nnjA-1ukmA:
undetectable		 2nnjA-1ukmA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ukm EMS16 A CHAIN
EMS16 B CHAIN
(Echis
multisquamatus) 		4 / 7 TYR B  86
TRP A 116
TYR A  11
ILE A  70
 None
 1.03A 2ph9A-1ukmB:
0.0
2ph9B-1ukmB:
0.0		 2ph9A-1ukmB:
18.11
2ph9B-1ukmB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 VAL A 128
TRP A  25
TRP A  69
 None
 1.24A 2xdcA-1ukmA:
undetectable
2xdcB-1ukmA:
undetectable		 2xdcA-1ukmA:
9.91
2xdcB-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A 128
TRP A  25
 None
 1.26A 2xdcA-1ukmA:
undetectable
2xdcB-1ukmA:
undetectable		 2xdcA-1ukmA:
9.91
2xdcB-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 VAL A 128
TRP A  25
TRP A  69
 None
 1.26A 2xdcC-1ukmA:
undetectable
2xdcD-1ukmA:
undetectable		 2xdcC-1ukmA:
9.91
2xdcD-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A 128
TRP A  25
 None
 0.99A 2xdcC-1ukmA:
undetectable
2xdcD-1ukmA:
undetectable		 2xdcC-1ukmA:
9.91
2xdcD-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 1ukm EMS16 B CHAIN
(Echis
multisquamatus) 		3 / 3 TRP B  64
VAL B 119
TRP B  22
 None
 1.12A 2xdcC-1ukmB:
undetectable
2xdcD-1ukmB:
undetectable		 2xdcC-1ukmB:
23.33
2xdcD-1ukmB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A 128
TRP A  25
 None
 1.02A 2xdcE-1ukmA:
undetectable
2xdcF-1ukmA:
undetectable		 2xdcE-1ukmA:
9.91
2xdcF-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 1ukm EMS16 B CHAIN
(Echis
multisquamatus) 		3 / 3 TRP B  64
VAL B 119
TRP B  22
 None
 1.16A 2xdcE-1ukmB:
undetectable
2xdcF-1ukmB:
undetectable		 2xdcE-1ukmB:
23.33
2xdcF-1ukmB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 VAL A 128
TRP A  25
TRP A  69
 None
 1.23A 2y5mA-1ukmA:
undetectable
2y5mB-1ukmA:
undetectable		 2y5mA-1ukmA:
9.91
2y5mB-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A 128
TRP A  25
 None
 0.99A 2y5mE-1ukmA:
undetectable
2y5mF-1ukmA:
undetectable		 2y5mE-1ukmA:
9.91
2y5mF-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 B CHAIN
(Echis
multisquamatus) 		3 / 3 TRP B  64
VAL B 119
TRP B  22
 None
 1.13A 2y5mE-1ukmB:
undetectable
2y5mF-1ukmB:
undetectable		 2y5mE-1ukmB:
23.33
2y5mF-1ukmB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 VAL A 128
TRP A  25
TRP A  69
 None
 1.23A 2y6nA-1ukmA:
undetectable
2y6nB-1ukmA:
undetectable		 2y6nA-1ukmA:
9.91
2y6nB-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A 128
TRP A  25
 None
 1.24A 2y6nA-1ukmA:
undetectable
2y6nB-1ukmA:
undetectable		 2y6nA-1ukmA:
9.91
2y6nB-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A 128
TRP A  25
 None
 0.97A 2y6nC-1ukmA:
undetectable
2y6nD-1ukmA:
undetectable		 2y6nC-1ukmA:
9.91
2y6nD-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 B CHAIN
(Echis
multisquamatus) 		3 / 3 TRP B  64
VAL B 119
TRP B  22
 None
 1.12A 2y6nC-1ukmB:
undetectable
2y6nD-1ukmB:
undetectable		 2y6nC-1ukmB:
23.33
2y6nD-1ukmB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A 128
TRP A  25
 None
 0.98A 2y6nE-1ukmA:
undetectable
2y6nF-1ukmA:
undetectable		 2y6nE-1ukmA:
9.91
2y6nF-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 B CHAIN
(Echis
multisquamatus) 		3 / 3 TRP B  64
VAL B 119
TRP B  22
 None
 1.12A 2y6nE-1ukmB:
undetectable
2y6nF-1ukmB:
undetectable		 2y6nE-1ukmB:
23.33
2y6nF-1ukmB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 1ukm EMS16 A CHAIN
EMS16 B CHAIN
(Echis
multisquamatus) 		5 / 11 PRO B  70
LYS A 102
GLN A 105
GLY A  71
GLU A  29
 None
GOL  B1303 (-3.0A)
None
None
None
 1.10A 3bf6H-1ukmB:
undetectable		 3bf6H-1ukmB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1ukm EMS16 A CHAIN
EMS16 B CHAIN
(Echis
multisquamatus;
Echis
multisquamatus) 		5 / 12 GLY A  71
ALA B  88
PHE A 127
THR A 108
LEU A 107
 None
 0.96A 3mteB-1ukmA:
undetectable		 3mteB-1ukmA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 1ukm EMS16 A CHAIN
EMS16 B CHAIN
(Echis
multisquamatus;
Echis
multisquamatus) 		5 / 12 GLY A  71
ALA B  88
PHE A 127
THR A 108
LEU A 107
 None
 0.86A 3p2kA-1ukmA:
undetectable		 3p2kA-1ukmA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 VAL A 128
TRP A  25
TRP A  69
 None
 1.20A 3zq8A-1ukmA:
undetectable
3zq8B-1ukmA:
undetectable		 3zq8A-1ukmA:
9.91
3zq8B-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1ukm EMS16 A CHAIN
(Echis
multisquamatus) 		3 / 3 TRP A  69
VAL A  42
TRP A  25
 None
 0.92A 3zq8C-1ukmA:
undetectable
3zq8D-1ukmA:
undetectable		 3zq8C-1ukmA:
9.91
3zq8D-1ukmA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1ukm EMS16 B CHAIN
(Echis
multisquamatus) 		4 / 7 VAL B  50
SER B  51
ALA B  54
VAL B 119
 None
 0.85A 5fpdA-1ukmB:
undetectable		 5fpdA-1ukmB:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1ukm EMS16 B CHAIN
(Echis
multisquamatus) 		4 / 7 VAL B  50
SER B  51
ALA B  54
VAL B 119
 None
 0.84A 5fpdB-1ukmB:
undetectable		 5fpdB-1ukmB:
15.30