SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ukv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 8 GLY Y  83
HIS Y  82
ALA Y 110
ILE Y  84
 None
 0.77A 1gtnE-1ukvY:
undetectable
1gtnF-1ukvY:
undetectable		 1gtnE-1ukvY:
17.14
1gtnF-1ukvY:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 8 GLY Y  83
HIS Y  82
ALA Y 110
ILE Y  84
 None
 0.73A 1gtnP-1ukvY:
undetectable
1gtnQ-1ukvY:
undetectable		 1gtnP-1ukvY:
17.14
1gtnQ-1ukvY:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 6 ASN Y  16
MET Y 145
LEU Y 103
ILE Y  73
 None
 0.87A 1z95A-1ukvY:
undetectable		 1z95A-1ukvY:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 8 THR Y  64
VAL Y  19
GLY Y  20
ILE Y  86
 None
GDP  Y1207 (-4.1A)
GDP  Y1207 (-2.9A)
None
 0.82A 2a1mB-1ukvY:
undetectable		 2a1mB-1ukvY:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		3 / 3 TRP Y 102
THR Y  64
TYR Y  77
 None
 1.12A 2a3aA-1ukvY:
3.3		 2a3aA-1ukvY:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		3 / 3 TRP Y 102
THR Y  64
TYR Y  77
 None
 1.14A 2a3aB-1ukvY:
3.4		 2a3aB-1ukvY:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		3 / 3 TRP Y 102
THR Y  64
TYR Y  77
 None
 1.14A 2a3bA-1ukvY:
3.4		 2a3bA-1ukvY:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 6 ASP Y  63
SER Y  22
SER Y  39
GLY Y  42
 MG  Y1208 ( 4.0A)
MG  Y1208 ( 2.1A)
None
None
 0.93A 2j2pA-1ukvY:
undetectable
2j2pC-1ukvY:
undetectable		 2j2pA-1ukvY:
22.44
2j2pC-1ukvY:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 6 ASP Y  63
SER Y  22
SER Y  39
GLY Y  42
 MG  Y1208 ( 4.0A)
MG  Y1208 ( 2.1A)
None
None
 0.98A 2j2pD-1ukvY:
undetectable
2j2pF-1ukvY:
undetectable		 2j2pD-1ukvY:
22.44
2j2pF-1ukvY:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		5 / 12 TYR Y  78
ILE Y  84
GLY Y  98
VAL Y 119
TYR Y  88
 None
 1.45A 2nyrB-1ukvY:
4.0		 2nyrB-1ukvY:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		5 / 12 GLN Y 168
ILE Y  61
ALA Y 161
PHE Y 162
LEU Y  13
 None
 1.00A 2qb4A-1ukvY:
undetectable		 2qb4A-1ukvY:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		5 / 11 GLN Y 168
ILE Y  61
ALA Y 161
PHE Y 162
LEU Y  13
 None
 1.07A 2qjuA-1ukvY:
undetectable		 2qjuA-1ukvY:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 7 ASN Y  16
MET Y 145
LEU Y 103
ILE Y  73
 None
 0.82A 4ojbA-1ukvY:
undetectable		 4ojbA-1ukvY:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 8 ASN Y  16
MET Y 145
LEU Y 103
ILE Y  73
 None
 0.92A 4ok1A-1ukvY:
undetectable		 4ok1A-1ukvY:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 7 ASN Y  16
MET Y 145
LEU Y 103
ILE Y  73
 None
 0.89A 4okwA-1ukvY:
undetectable		 4okwA-1ukvY:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		5 / 12 ILE Y  61
LEU Y  13
GLU Y 159
PHE Y 162
ARG Y  27
 None
 1.30A 5k7uA-1ukvY:
undetectable		 5k7uA-1ukvY:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		4 / 7 ASP Y  63
LEU Y  13
THR Y  64
VAL Y  19
 MG  Y1208 ( 4.0A)
None
None
GDP  Y1207 (-4.1A)
 1.08A 5ov9A-1ukvY:
undetectable		 5ov9A-1ukvY:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1ukv GTP-BINDING PROTEIN
YPT1
(Saccharomyces
cerevisiae) 		3 / 3 ARG Y  79
PHE Y   9
LEU Y  12
 None
 0.82A 5veuA-1ukvY:
undetectable		 5veuA-1ukvY:
17.45