SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ukw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 LEU A  82
VAL A 128
LEU A 129
LEU A 144
LEU A 141
LEU A 150
 None
 1.49A 1mx1D-1ukwA:
undetectable		 1mx1D-1ukwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 388
SER A 188
SER A 237
VAL A 276
LEU A 269
 FAD  A 420 (-4.2A)
FAD  A 420 (-3.0A)
None
None
None
 1.33A 1rk3A-1ukwA:
0.4		 1rk3A-1ukwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TYR A 115
ARG A  48
GLN A  44
 None
 1.00A 1tw4A-1ukwA:
undetectable		 1tw4A-1ukwA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A  82
LEU A 150
PRO A  69
VAL A  68
 None
 1.21A 2dqyC-1ukwA:
0.4		 2dqyC-1ukwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A 214
GLU A 258
ALA A 200
THR A 169
 None
 1.08A 2roxB-1ukwA:
undetectable		 2roxB-1ukwA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 388
SER A 188
SER A 237
VAL A 276
LEU A 269
 FAD  A 420 (-4.2A)
FAD  A 420 (-3.0A)
None
None
None
 1.32A 2zlcA-1ukwA:
1.6		 2zlcA-1ukwA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 TYR A 330
GLY A 279
GLY A 104
ASP A 385
ARG A 326
 None
 1.33A 3dlcA-1ukwA:
undetectable		 3dlcA-1ukwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 TYR A 330
GLY A 279
GLY A 104
VAL A 386
ARG A 326
 None
 1.17A 3dlcA-1ukwA:
undetectable		 3dlcA-1ukwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ILE A 117
ALA A 120
LEU A 150
ALA A 151
ILE A  55
 None
 0.93A 3falC-1ukwA:
undetectable		 3falC-1ukwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ILE A 117
ALA A 120
LEU A 150
ALA A 151
ILE A  55
 None
 0.91A 3fc6A-1ukwA:
undetectable		 3fc6A-1ukwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A 141
MET A  93
GLY A  80
HIS A  77
LEU A  82
 None
 1.19A 3hm1B-1ukwA:
0.6		 3hm1B-1ukwA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 TYR A 115
GLY A 104
VAL A 386
GLN A 390
GLY A 282
 None
 1.19A 3kmoA-1ukwA:
undetectable		 3kmoA-1ukwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 388
SER A 188
SER A 237
VAL A 276
LEU A 269
 FAD  A 420 (-4.2A)
FAD  A 420 (-3.0A)
None
None
None
 1.26A 3m7rA-1ukwA:
2.1		 3m7rA-1ukwA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ILE A  73
ALA A 120
THR A 116
VAL A  68
 None
 0.85A 3me6B-1ukwA:
0.0		 3me6B-1ukwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 117
ALA A 120
LEU A 150
ALA A 151
ILE A  55
 None
 0.93A 3oapA-1ukwA:
undetectable		 3oapA-1ukwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 388
SER A 188
SER A 237
VAL A 276
LEU A 269
 FAD  A 420 (-4.2A)
FAD  A 420 (-3.0A)
None
None
None
 1.37A 3vt3A-1ukwA:
0.0		 3vt3A-1ukwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TYR A 352
THR A 324
GLU A 359
 None
 0.73A 4df3A-1ukwA:
undetectable		 4df3A-1ukwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TYR A 352
THR A 324
GLU A 359
 None
 0.76A 4df3B-1ukwA:
undetectable		 4df3B-1ukwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 LEU A 141
LEU A 144
ILE A  86
ASP A 122
GLY A 124
LEU A 129
 None
 1.25A 4lmnA-1ukwA:
undetectable		 4lmnA-1ukwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 117
ALA A 120
LEU A 150
ALA A 151
ILE A  55
 None
 0.95A 4nqaH-1ukwA:
undetectable		 4nqaH-1ukwA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ALA A 171
LEU A 180
LEU A 214
GLU A 157
 None
 0.78A 4po0A-1ukwA:
2.4		 4po0A-1ukwA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A 141
MET A  93
GLY A  80
HIS A  77
LEU A  82
 None
 1.14A 4pxmB-1ukwA:
0.0		 4pxmB-1ukwA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 TYR A 115
ILE A 125
LEU A  76
LEU A  82
 None
 1.01A 4xo7A-1ukwA:
undetectable		 4xo7A-1ukwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A 141
MET A  93
GLY A  80
HIS A  77
LEU A  82
 None
 1.17A 5dxgB-1ukwA:
0.5		 5dxgB-1ukwA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 159
GLU A 393
SER A 188
ILE A 187
PHE A 153
 None
None
FAD  A 420 (-3.0A)
FAD  A 420 ( 4.4A)
FAD  A 420 (-4.8A)
 1.15A 5igyA-1ukwA:
undetectable		 5igyA-1ukwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 LEU A  82
LYS A 147
LEU A 150
GLU A 194
 None
 1.19A 5weaA-1ukwA:
undetectable		 5weaA-1ukwA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 117
ALA A 120
LEU A 150
ALA A 151
ILE A  55
 None
 0.93A 6a5zD-1ukwA:
undetectable		 6a5zD-1ukwA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 117
ALA A 120
LEU A 150
ALA A 151
ILE A  55
 None
 0.92A 6a5zL-1ukwA:
undetectable		 6a5zL-1ukwA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 GLU A 135
ARG A 139
VAL A 251
PRO A 250
 None
 1.32A 6fgdA-1ukwA:
undetectable		 6fgdA-1ukwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1ukw ACYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 TRP A 195
ALA A 193
LEU A 150
ALA A 149
 None
 1.17A 6fosB-1ukwA:
2.9		 6fosB-1ukwA:
11.43