SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 1uky URIDYLATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  45
ARG A  86
ILE A 119
PHE A 115
ILE A 102
 None
 1.24A 1ot7B-1ukyA:
0.1		 1ot7B-1ukyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1uky URIDYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 191
SER A 188
GLU A 137
ASP A 133
 None
 1.34A 3bc9A-1ukyA:
undetectable		 3bc9A-1ukyA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1uky URIDYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  80
LEU A  51
LYS A 158
GLY A  73
 None
ADP  A 206 (-4.9A)
None
ADP  A 206 ( 4.2A)
 0.97A 4hajA-1ukyA:
undetectable		 4hajA-1ukyA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1uky URIDYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A  40
ILE A 200
ASP A 103
PHE A  42
 None
None
ADP  A 205 ( 4.9A)
None
 0.93A 4iqqA-1ukyA:
undetectable		 4iqqA-1ukyA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 1uky URIDYLATE KINASE
(Saccharomyces
cerevisiae) 		5 / 10 ASP A  49
GLY A  30
SER A  46
GLY A 104
ASP A 151
 None
ADP  A 205 (-3.5A)
ADP  A 206 ( 4.6A)
None
None
 1.34A 4mmcA-1ukyA:
0.0		 4mmcA-1ukyA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 1uky URIDYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 7 LYS A  29
ARG A 107
GLY A  48
SER A  46
 ADP  A 205 ( 2.7A)
ADP  A 206 (-3.3A)
ADP  A 206 ( 3.7A)
ADP  A 206 ( 4.6A)
 1.21A 5bphB-1ukyA:
2.9		 5bphB-1ukyA:
22.61