SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ule'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		4 / 7 SER A  27
PHE A  84
PHE A  39
LEU A  50
 None
 0.99A 1qcaA-1uleA:
undetectable		 1qcaA-1uleA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		5 / 12 LEU A 131
PHE A 132
ILE A  91
ILE A 102
ILE A  61
 None
 1.25A 2efjA-1uleA:
undetectable		 2efjA-1uleA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		5 / 6 HIS A  51
ARG A  55
ASN A  64
TRP A  72
GLU A  75
 GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
GAL  A 152 (-3.9A)
GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
 0.30A 3galA-1uleA:
16.9		 3galA-1uleA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		5 / 6 HIS A  51
ARG A  55
ASN A  64
TRP A  72
GLU A  75
 GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
GAL  A 152 (-3.9A)
GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
 0.39A 3galB-1uleA:
16.4		 3galB-1uleA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		5 / 11 VAL A  62
PHE A  84
PHE A  30
GLY A  35
GLY A  34
 None
 1.21A 3owxA-1uleA:
undetectable
3owxB-1uleA:
undetectable		 3owxA-1uleA:
19.74
3owxB-1uleA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		5 / 10 GLY A  35
GLY A  34
VAL A  60
PHE A  84
PHE A 132
 None
 1.49A 4fgkA-1uleA:
undetectable
4fgkB-1uleA:
undetectable		 4fgkA-1uleA:
19.74
4fgkB-1uleA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		3 / 3 ARG A  66
TRP A  72
ILE A  48
 None
GAL  A 152 (-3.8A)
None
 1.01A 4mwxA-1uleA:
undetectable		 4mwxA-1uleA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		4 / 7 SER A 130
TYR A  80
PHE A  39
SER A  27
 None
 1.18A 5l1fC-1uleA:
undetectable		 5l1fC-1uleA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		6 / 7 HIS A  51
ARG A  55
ASN A  64
TRP A  72
GLU A  75
ARG A  77
 GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
GAL  A 152 (-3.9A)
GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
NAG  A 153 (-3.5A)
 0.30A 6b8kA-1uleA:
17.2		 6b8kA-1uleA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		6 / 8 HIS A  51
ARG A  55
ASN A  64
TRP A  72
GLU A  75
ARG A  77
 GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
GAL  A 152 (-3.9A)
GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
NAG  A 153 (-3.5A)
 0.48A 6b94A-1uleA:
16.1		 6b94A-1uleA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		6 / 10 HIS A  51
ARG A  55
ASN A  64
TRP A  72
GLU A  75
ARG A  77
 GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
GAL  A 152 (-3.9A)
GAL  A 152 (-3.8A)
NAG  A 153 ( 2.8A)
NAG  A 153 (-3.5A)
 0.45A 6b94A-1uleA:
16.1
6b94B-1uleA:
15.2		 6b94A-1uleA:
27.62
6b94B-1uleA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		4 / 4 ARG A  55
GLU A  58
GLU A  75
ARG A  77
 NAG  A 153 ( 2.8A)
None
NAG  A 153 ( 2.8A)
NAG  A 153 (-3.5A)
 0.59A 6fk2A-1uleA:
17.3		 6fk2A-1uleA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 1ule GALECTIN-2
(Coprinopsis
cinerea) 		4 / 4 ARG A  77
GLU A  75
GLU A  58
ARG A  55
 NAG  A 153 (-3.5A)
NAG  A 153 ( 2.8A)
None
NAG  A 153 ( 2.8A)
 0.96A 6fk2A-1uleA:
17.3		 6fk2A-1uleA:
23.90