SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ulq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A  53
LEU A  34
LEU A  21
ALA A 360
THR A  84
 None
 0.94A 1bzfA-1ulqA:
undetectable		 1bzfA-1ulqA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 ARG A 200
ARG A 194
HIS A 189
ALA A 353
GLY A 355
 None
 1.43A 1cmcA-1ulqA:
undetectable
1cmcB-1ulqA:
undetectable		 1cmcA-1ulqA:
19.73
1cmcB-1ulqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ALA A 327
THR A 246
PHE A 184
 None
 0.76A 2c6nB-1ulqA:
undetectable		 2c6nB-1ulqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A  31
ALA A 259
LEU A  72
LEU A  73
VAL A  80
 None
 1.02A 2nyuA-1ulqA:
undetectable		 2nyuA-1ulqA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASP A  27
THR A  12
PRO A  13
 None
 0.64A 2pynB-1ulqA:
undetectable		 2pynB-1ulqA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASP A  27
THR A  12
PRO A  13
 None
 0.63A 2q64B-1ulqA:
undetectable		 2q64B-1ulqA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASP A  27
THR A  12
PRO A  13
 None
 0.62A 2qakB-1ulqA:
undetectable		 2qakB-1ulqA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ARG A 121
GLU A 216
SER A 120
 None
 0.88A 2xkkA-1ulqA:
undetectable
2xkkC-1ulqA:
undetectable		 2xkkA-1ulqA:
20.52
2xkkC-1ulqA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 SER A 120
GLY A  19
GLY A  15
 None
 0.54A 3bogA-1ulqA:
undetectable
3bogC-1ulqA:
undetectable		 3bogA-1ulqA:
undetectable
3bogC-1ulqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 382
LEU A 366
ALA A 383
ALA A  97
VAL A 281
 None
 1.27A 3e22B-1ulqA:
undetectable		 3e22B-1ulqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 382
LEU A 366
ALA A 383
ALA A  97
VAL A 281
 None
 1.27A 3e22D-1ulqA:
undetectable		 3e22D-1ulqA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 8 LEU A  93
VAL A 370
LEU A 369
ILE A   6
VAL A 397
 None
 1.28A 3kp6A-1ulqA:
undetectable
3kp6B-1ulqA:
undetectable		 3kp6A-1ulqA:
18.03
3kp6B-1ulqA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  34
LEU A  37
VAL A  38
SER A  41
VAL A  51
 None
 1.24A 3m7rA-1ulqA:
undetectable		 3m7rA-1ulqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 VAL A 289
GLY A 392
ILE A 393
VAL A 332
 None
 0.81A 3ufnB-1ulqA:
undetectable		 3ufnB-1ulqA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
 None
 1.14A 4j6cA-1ulqA:
undetectable		 4j6cA-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
 None
 1.14A 4j6cB-1ulqA:
undetectable		 4j6cB-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
 None
 1.03A 4j6dA-1ulqA:
undetectable		 4j6dA-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
 None
 1.02A 4j6dB-1ulqA:
undetectable		 4j6dB-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
 None
 1.08A 4jbtA-1ulqA:
undetectable		 4jbtA-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 GLN A 391
ALA A 287
ALA A 285
VAL A 396
LEU A 382
 None
 1.07A 4jbtB-1ulqA:
undetectable		 4jbtB-1ulqA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 ASN A 346
ASP A 342
GLY A 317
THR A 368
 None
 1.09A 4l1aB-1ulqA:
undetectable		 4l1aB-1ulqA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 LEU A 321
ASN A 346
LEU A 382
VAL A 378
 None
 1.04A 4okbA-1ulqA:
undetectable		 4okbA-1ulqA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 ALA A 394
THR A 302
ALA A 305
ILE A 387
GLY A 297
 None
 1.10A 4qvqK-1ulqA:
undetectable
4qvqL-1ulqA:
undetectable		 4qvqK-1ulqA:
18.91
4qvqL-1ulqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 ALA A 394
THR A 302
ALA A 305
ILE A 387
GLY A 297
 None
 1.10A 4qvqY-1ulqA:
undetectable
4qvqZ-1ulqA:
undetectable		 4qvqY-1ulqA:
18.91
4qvqZ-1ulqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 GLY A 392
ALA A 287
GLY A 297
PRO A 298
 None
 0.91A 4u9uA-1ulqA:
undetectable		 4u9uA-1ulqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 115
GLY A 359
ASN A  57
ALA A 261
ALA A 259
 None
 0.99A 4uciA-1ulqA:
undetectable		 4uciA-1ulqA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 115
GLY A 359
ASN A  57
ALA A 261
ALA A 259
 None
 0.99A 4uciB-1ulqA:
undetectable		 4uciB-1ulqA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 ALA A 259
LEU A  21
SER A  35
LEU A  34
ALA A  31
 None
 1.09A 4zbrA-1ulqA:
0.0		 4zbrA-1ulqA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 8 ALA A  53
VAL A  85
GLY A 115
ALA A 360
GLY A 359
 None
 1.41A 4zjzB-1ulqA:
undetectable		 4zjzB-1ulqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 LEU A 321
GLY A 295
GLY A 297
LEU A 330
LEU A 170
 None
 1.04A 5l0zB-1ulqA:
undetectable		 5l0zB-1ulqA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ILE A 365
PRO A 357
GLU A 323
GLY A 350
HIS A 189
 None
 1.09A 5l6eA-1ulqA:
undetectable		 5l6eA-1ulqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 ARG A 194
ILE A 352
GLY A 350
GLY A 349
LEU A 186
 None
 1.02A 5o96A-1ulqA:
undetectable
5o96B-1ulqA:
undetectable		 5o96A-1ulqA:
22.82
5o96B-1ulqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		 1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 SER A 361
ASN A 322
HIS A 356
GLU A 320
GLU A 204
 None
 1.42A 6cggB-1ulqA:
0.0		 6cggB-1ulqA:
20.33