SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uls'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		4 / 4 ALA A  46
VAL A  49
ALA A  51
HIS A  52
 None
 1.06A 1q23F-1ulsA:
undetectable		 1q23F-1ulsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		4 / 4 ALA A  46
VAL A  49
ALA A  51
HIS A  52
 None
 1.02A 1q23K-1ulsA:
undetectable		 1q23K-1ulsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		4 / 8 ASN A 108
HIS A  83
SER A 112
VAL A 155
 None
 1.33A 1u1jA-1ulsA:
2.1		 1u1jA-1ulsA:
14.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		7 / 11 GLY A  12
ALA A  14
ASP A  36
ASP A  57
VAL A  58
ALA A  85
VAL A 107
 None
 0.52A 1uayA-1ulsA:
30.7		 1uayA-1ulsA:
39.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		7 / 10 GLY A  12
ALA A  14
ASP A  36
ASP A  57
VAL A  58
ALA A  85
VAL A 107
 None
 0.55A 1uayB-1ulsA:
31.3		 1uayB-1ulsA:
39.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		4 / 8 ASN A 108
SER A 151
TYR A  84
SER A 136
 None
 1.09A 2zw9B-1ulsA:
5.4		 2zw9B-1ulsA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		5 / 10 ASP A  36
ILE A  37
ALA A  14
ASP A  57
VAL A  58
 None
 0.90A 3ay0A-1ulsA:
6.2		 3ay0A-1ulsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A  18
GLY A  16
LEU A 210
PRO A 209
ALA A  45
 None
 1.07A 3i5uA-1ulsA:
6.0		 3i5uA-1ulsA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A  18
GLY A  16
LEU A 210
PRO A 209
ALA A  45
 None
 1.09A 3i5uB-1ulsA:
6.5		 3i5uB-1ulsA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		5 / 12 GLY A  16
GLY A  18
VAL A 212
GLU A 182
THR A 186
 None
 1.10A 3p2kB-1ulsA:
5.0		 3p2kB-1ulsA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		4 / 8 ASP A  36
GLY A  12
PRO A  41
GLU A  38
 None
 0.98A 3s3mA-1ulsA:
undetectable		 3s3mA-1ulsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		4 / 8 ASP A  36
GLY A  12
PRO A  41
GLU A  38
 None
 0.96A 3s3nA-1ulsA:
undetectable		 3s3nA-1ulsA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		5 / 11 ILE A  10
LEU A 133
LEU A  78
GLY A  80
ALA A 118
 None
 1.29A 4fogD-1ulsA:
undetectable		 4fogD-1ulsA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		6 / 10 GLU A 165
ILE A 171
VAL A 173
ALA A 116
ALA A 119
ILE A 131
 None
 1.39A 4lbgA-1ulsA:
6.7		 4lbgA-1ulsA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		4 / 7 ALA A  51
GLY A  29
ALA A  30
GLU A  28
 None
 0.83A 4r1zB-1ulsA:
undetectable		 4r1zB-1ulsA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		4 / 6 ILE A 181
PRO A 209
ILE A  10
VAL A  82
 None
 0.96A 4zj8A-1ulsA:
4.9		 4zj8A-1ulsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		3 / 3 THR A 183
THR A  21
LEU A 176
 None
 0.68A 5m66D-1ulsA:
8.9		 5m66D-1ulsA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		3 / 3 PHE A  92
ASP A  90
LEU A  98
 None
 0.73A 5uhbC-1ulsA:
undetectable		 5uhbC-1ulsA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		3 / 3 PHE A  92
ASP A  90
LEU A  98
 None
 0.79A 5uhcC-1ulsA:
undetectable		 5uhcC-1ulsA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1uls PUTATIVE
3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE
(Thermus
thermophilus) 		5 / 10 ARG A 137
PHE A 233
GLY A 141
GLY A 157
VAL A 155
 None
 1.19A 6eu9B-1ulsA:
0.0		 6eu9B-1ulsA:
18.34