SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ulz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		3 / 4 VAL A 399
TRP A 391
TRP A 395
 None
 1.29A 1gmkC-1ulzA:
undetectable
1gmkD-1ulzA:
undetectable		 1gmkC-1ulzA:
5.00
1gmkD-1ulzA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 7 GLU A 239
MET A 301
MET A 402
ALA A 398
 None
 1.27A 1linA-1ulzA:
0.0		 1linA-1ulzA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		3 / 3 ILE A  65
LEU A  68
VAL A  72
 None
 0.46A 1mz9B-1ulzA:
undetectable		 1mz9B-1ulzA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 8 VAL A 294
PRO A 297
VAL A 298
SER A 299
 None
 0.98A 2v32C-1ulzA:
undetectable
2v32D-1ulzA:
undetectable		 2v32C-1ulzA:
18.75
2v32D-1ulzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 7 PRO A 297
VAL A 298
SER A 299
GLU A 209
 None
 1.01A 2v41E-1ulzA:
undetectable
2v41F-1ulzA:
undetectable		 2v41E-1ulzA:
18.75
2v41F-1ulzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 8 PHE A  83
GLU A  89
ILE A  65
ALA A   8
 None
 0.96A 3aodA-1ulzA:
undetectable		 3aodA-1ulzA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		6 / 12 LEU A 223
GLY A 271
ALA A 270
VAL A 308
PRO A 297
ILE A 307
 None
 1.39A 3bvbB-1ulzA:
undetectable		 3bvbB-1ulzA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		3 / 3 MET A 288
VAL A 258
GLU A 209
 None
 0.91A 3c6gA-1ulzA:
undetectable		 3c6gA-1ulzA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 6 GLY A 164
THR A 159
GLU A 186
GLU A 181
 None
 1.02A 3fpjA-1ulzA:
3.3		 3fpjA-1ulzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 6 GLY A 224
THR A 259
GLU A 225
GLU A 249
 None
 0.93A 3fpjA-1ulzA:
3.3		 3fpjA-1ulzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		5 / 12 LEU A 213
ASN A 219
TYR A 267
TYR A 268
GLY A 218
 None
 1.36A 3medA-1ulzA:
1.8
3medB-1ulzA:
undetectable		 3medA-1ulzA:
20.00
3medB-1ulzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 8 GLU A  12
TYR A 357
PHE A 375
ASP A 382
 None
 1.13A 3mjrD-1ulzA:
undetectable		 3mjrD-1ulzA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		3 / 3 HIS A 296
ARG A  16
GLU A  12
 None
 1.18A 3qf1A-1ulzA:
undetectable		 3qf1A-1ulzA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		5 / 12 VAL A  15
PRO A  79
ILE A 312
VAL A   5
ILE A  77
 None
 1.33A 4eb6B-1ulzA:
undetectable
4eb6C-1ulzA:
undetectable		 4eb6B-1ulzA:
22.81
4eb6C-1ulzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 6 ARG A 148
ILE A 150
VAL A 154
LEU A 198
 None
 1.10A 4em2A-1ulzA:
undetectable		 4em2A-1ulzA:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		7 / 7 LYS A 236
ASN A 289
ARG A 291
GLN A 293
VAL A 294
GLU A 295
ARG A 337
 None
 0.30A 4mv7A-1ulzA:
57.4		 4mv7A-1ulzA:
50.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		3 / 3 LEU A 223
LEU A 246
ASN A 256
 None
 0.75A 4otwA-1ulzA:
0.8		 4otwA-1ulzA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 5 LEU A 244
VAL A 399
VAL A 238
TYR A 332
 None
 1.09A 4r7iA-1ulzA:
undetectable		 4r7iA-1ulzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		5 / 12 ALA A 143
GLU A 142
LEU A 196
LEU A 137
LEU A 176
 None
 1.08A 4zn7A-1ulzA:
undetectable		 4zn7A-1ulzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		5 / 11 LEU A 140
ALA A 143
GLU A 142
LEU A 196
LEU A 137
 None
 1.34A 4zn7B-1ulzA:
undetectable		 4zn7B-1ulzA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		5 / 12 ILE A  51
VAL A  29
ALA A  74
VAL A  72
GLY A  98
 None
 0.95A 5igiA-1ulzA:
undetectable		 5igiA-1ulzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		5 / 12 ILE A  51
VAL A  29
ALA A  74
VAL A  72
GLY A  98
 None
 0.96A 5igjA-1ulzA:
undetectable		 5igjA-1ulzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		5 / 12 ILE A  51
VAL A  29
ALA A  74
VAL A  72
GLY A  98
 None
 0.97A 5igtA-1ulzA:
undetectable		 5igtA-1ulzA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 5 SER A 299
ASN A 219
GLN A 324
ASP A 215
 None
 1.38A 5kpcA-1ulzA:
2.3		 5kpcA-1ulzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN
(Aquifex
aeolicus) 		4 / 8 PHE A 435
PHE A 430
MET A 425
LEU A 244
 None
 1.03A 5y2tB-1ulzA:
0.0		 5y2tB-1ulzA:
undetectable