SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1um1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		4 / 8 GLY A  84
ASN A  65
GLY A  85
VAL A  12
 None
 0.88A 1dbbH-1um1A:
undetectable
1dbbL-1um1A:
undetectable		 1dbbH-1um1A:
20.00
1dbbL-1um1A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		5 / 12 ASP A  27
LEU A  38
THR A  99
ILE A 103
SER A  56
 None
 1.49A 1xoqA-1um1A:
undetectable		 1xoqA-1um1A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		5 / 12 ASP A  27
LEU A  38
THR A  99
ILE A 103
SER A  56
 None
 1.48A 1xoqB-1um1A:
undetectable		 1xoqB-1um1A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		4 / 8 TYR A  39
GLN A  41
ILE A 103
ASP A  27
 None
 1.05A 2xytE-1um1A:
undetectable		 2xytE-1um1A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		4 / 8 TYR A  39
GLN A  41
ILE A 103
ASP A  27
 None
 1.13A 2xytH-1um1A:
undetectable		 2xytH-1um1A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		4 / 7 TYR A  39
GLN A  41
ILE A 103
ASP A  27
 None
 1.11A 2xytI-1um1A:
undetectable		 2xytI-1um1A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		5 / 12 ASP A  27
LEU A  38
THR A  99
ILE A 103
SER A  56
 None
 1.46A 3g4lD-1um1A:
undetectable		 3g4lD-1um1A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		4 / 5 HIS A  83
LEU A  25
LEU A  69
ASP A  27
 None
 1.31A 4aqlA-1um1A:
undetectable		 4aqlA-1um1A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		3 / 3 TYR A   8
ARG A  54
LYS A  94
 None
 1.39A 4wq5B-1um1A:
undetectable		 4wq5B-1um1A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  43
ASN A  65
ALA A  49
LEU A  55
GLY A  84
 None
 1.05A 5kb5A-1um1A:
undetectable		 5kb5A-1um1A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1um1 KIAA1849 PROTEIN
(Homo
sapiens) 		5 / 12 PHE A  90
ILE A  81
LEU A  25
ALA A  49
LEU A  43
 None
 1.42A 5zwrB-1um1A:
undetectable		 5zwrB-1um1A:
16.79