SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1um2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 496
ILE A 622
ILE A 586
LEU A 633
HIS A 626
 None
 1.18A 1kyvA-1um2A:
undetectable
1kyvE-1um2A:
undetectable		 1kyvA-1um2A:
18.71
1kyvE-1um2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 586
LEU A 633
HIS A 626
GLY A 496
ILE A 622
 None
 1.18A 1kyvB-1um2A:
undetectable
1kyvC-1um2A:
undetectable		 1kyvB-1um2A:
18.71
1kyvC-1um2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 586
LEU A 633
HIS A 626
GLY A 496
ILE A 622
 None
 1.14A 1kyvC-1um2A:
undetectable
1kyvD-1um2A:
undetectable		 1kyvC-1um2A:
18.71
1kyvD-1um2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 586
LEU A 633
HIS A 626
GLY A 496
ILE A 622
 None
 1.16A 1kyvD-1um2A:
undetectable
1kyvE-1um2A:
undetectable		 1kyvD-1um2A:
18.71
1kyvE-1um2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 640
ALA A 463
MET A 311
LEU A 728
ILE A 595
 None
 1.02A 1s9pA-1um2A:
undetectable		 1s9pA-1um2A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 719
VAL A 320
VAL A 291
ILE A 301
 None
 0.96A 1t87B-1um2A:
undetectable		 1t87B-1um2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 526
LEU A 494
GLU A 566
MET A 476
SER A 479
 None
 1.48A 1wrlC-1um2A:
0.1
1wrlD-1um2A:
undetectable		 1wrlC-1um2A:
12.83
1wrlD-1um2A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 640
LEU A 642
LEU A 633
LEU A 590
 None
 1.04A 2ab2A-1um2A:
undetectable		 2ab2A-1um2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 7 SER A 669
LYS A 619
SER A 645
VAL A 643
 None
 1.23A 2j9cA-1um2A:
1.1
2j9cB-1um2A:
1.3
2j9cC-1um2A:
1.0		 2j9cA-1um2A:
15.54
2j9cB-1um2A:
15.54
2j9cC-1um2A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 294
GLY A 296
ASP A 314
ARG A 316
 None
 0.78A 2uyqA-1um2A:
undetectable		 2uyqA-1um2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 500
GLY A 502
VAL A 511
LEU A 605
SER A 504
 None
 1.25A 3mteA-1um2A:
undetectable		 3mteA-1um2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 304
HIS A 725
VAL A 365
PHE A 285
 None
 1.03A 4a97H-1um2A:
undetectable		 4a97H-1um2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 333
LEU A 364
VAL A 366
PHE A 704
 None
 1.05A 4lb0B-1um2A:
undetectable		 4lb0B-1um2A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1um2 ENDONUCLEASE PI-SCEI
21-MER FROM VACUOLAR
ATP SYNTHASE
CATALYTIC SUBUNIT A
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ARG C 741
ARG A 445
ASP A 446
ILE A 442
 None
 1.27A 5a06B-1um2C:
undetectable		 5a06B-1um2C:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 647
ALA A 648
PRO A 351
VAL A 646
 None
 1.14A 5umd2-1um2A:
undetectable
5umdF-1um2A:
undetectable		 5umd2-1um2A:
11.21
5umdF-1um2A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 666
ALA A 620
LEU A 602
ILE A 499
PRO A 587
 None
 1.40A 5z6lA-1um2A:
undetectable		 5z6lA-1um2A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 736
ASN A 737
LEU A 719
 None
 0.84A 6f7lB-1um2A:
undetectable		 6f7lB-1um2A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1um2 ENDONUCLEASE PI-SCEI
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 734
ALA A 463
GLN A 726
 None
 0.70A 6gb9A-1um2A:
undetectable		 6gb9A-1um2A:
23.50