SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1um4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
4 / 6 LEU H 195
GLY H 196
ALA H 131
PRO H 132
None
0.51A 3huoA-1um4H:
undetectable
3huoA-1um4H:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
4 / 8 LEU H  87
SER H  86
LEU H  82
TYR H  95
None
0.75A 3ln1A-1um4H:
undetectable
3ln1A-1um4H:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
4 / 8 LEU H 130
ALA H 143
SER H 133
SER H 134
None
0.97A 4ikkA-1um4H:
undetectable
4ikkB-1um4H:
undetectable
4ikkA-1um4H:
21.86
4ikkB-1um4H:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.83A 4qvnH-1um4H:
undetectable
4qvnI-1um4H:
undetectable
4qvnH-1um4H:
22.45
4qvnI-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 10 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.83A 4qvnV-1um4H:
undetectable
4qvnW-1um4H:
undetectable
4qvnV-1um4H:
22.45
4qvnW-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.80A 4qvpH-1um4H:
undetectable
4qvpI-1um4H:
undetectable
4qvpH-1um4H:
22.45
4qvpI-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.80A 4qvpV-1um4H:
undetectable
4qvpW-1um4H:
undetectable
4qvpV-1um4H:
22.45
4qvpW-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.82A 4qvqH-1um4H:
undetectable
4qvqI-1um4H:
undetectable
4qvqH-1um4H:
22.45
4qvqI-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.81A 4qvqV-1um4H:
undetectable
4qvqW-1um4H:
0.0
4qvqV-1um4H:
22.45
4qvqW-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.85A 4qvvH-1um4H:
undetectable
4qvvH-1um4H:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.85A 4qvvV-1um4H:
undetectable
4qvvV-1um4H:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.84A 4qvyH-1um4H:
undetectable
4qvyH-1um4H:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.84A 4qvyV-1um4H:
undetectable
4qvyW-1um4H:
undetectable
4qvyV-1um4H:
22.45
4qvyW-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.84A 4qw0H-1um4H:
undetectable
4qw0I-1um4H:
undetectable
4qw0H-1um4H:
22.45
4qw0I-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.84A 4qw0V-1um4H:
undetectable
4qw0W-1um4H:
undetectable
4qw0V-1um4H:
22.45
4qw0W-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.84A 4qw1H-1um4H:
undetectable
4qw1I-1um4H:
undetectable
4qw1H-1um4H:
22.45
4qw1I-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.84A 4qw1V-1um4H:
undetectable
4qw1W-1um4H:
undetectable
4qw1V-1um4H:
22.45
4qw1W-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.84A 4qwuH-1um4H:
undetectable
4qwuI-1um4H:
undetectable
4qwuH-1um4H:
22.45
4qwuI-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.84A 4qwuV-1um4H:
undetectable
4qwuW-1um4H:
undetectable
4qwuV-1um4H:
22.45
4qwuW-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.85A 5bxnH-1um4H:
undetectable
5bxnI-1um4H:
undetectable
5bxnH-1um4H:
20.75
5bxnI-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
4 / 5 THR H  88
GLY H  16
GLU H  83
ASP H  91
None
1.26A 5c0oH-1um4H:
undetectable
5c0oH-1um4H:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.83A 5cz7V-1um4H:
undetectable
5cz7W-1um4H:
undetectable
5cz7V-1um4H:
22.45
5cz7W-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 11 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.83A 5d0xV-1um4H:
undetectable
5d0xV-1um4H:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
3 / 3 THR H  29
ALA H  25
ASN H  78
None
0.63A 5ersA-1um4H:
undetectable
5ersA-1um4H:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.79A 5l5fH-1um4H:
undetectable
5l5fI-1um4H:
undetectable
5l5fH-1um4H:
22.45
5l5fI-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.79A 5l5fV-1um4H:
undetectable
5l5fW-1um4H:
undetectable
5l5fV-1um4H:
22.45
5l5fW-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.83A 5l66H-1um4H:
undetectable
5l66I-1um4H:
undetectable
5l66H-1um4H:
22.45
5l66I-1um4H:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.83A 5l66V-1um4H:
undetectable
5l66W-1um4H:
undetectable
5l66V-1um4H:
22.45
5l66W-1um4H:
24.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
4 / 5 SER H 118
ALA H 120
PHE H 152
LEU H 176
None
0.41A 5mthA-1um4H:
27.1
5mthA-1um4H:
67.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
1um4 ANTIBODY 21H3 H
CHAIN

(Mus
musculus)
5 / 12 SER H 194
GLY H 140
THR H 141
ALA H 142
THR H 137
None
0.93A 6hwdH-1um4H:
undetectable
6hwdI-1um4H:
undetectable
6hwdH-1um4H:
19.69
6hwdI-1um4H:
23.97