SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1um7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1um7 SYNAPSE-ASSOCIATED
PROTEIN 102
(Homo
sapiens) 		4 / 8 PHE A  42
ILE A  41
PHE A 105
GLY A  38
 None
 0.86A 2qwxA-1um7A:
undetectable
2qwxB-1um7A:
undetectable		 2qwxA-1um7A:
20.96
2qwxB-1um7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1um7 SYNAPSE-ASSOCIATED
PROTEIN 102
(Homo
sapiens) 		4 / 8 PHE A  42
ILE A  41
PHE A 105
GLY A  38
 None
 0.88A 2qx4A-1um7A:
undetectable
2qx4B-1um7A:
undetectable		 2qx4A-1um7A:
20.96
2qx4B-1um7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1um7 SYNAPSE-ASSOCIATED
PROTEIN 102
(Homo
sapiens) 		3 / 3 GLU A 106
TYR A 102
SER A  44
 None
 0.93A 4at0A-1um7A:
undetectable		 4at0A-1um7A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1um7 SYNAPSE-ASSOCIATED
PROTEIN 102
(Homo
sapiens) 		4 / 8 PHE A  42
ILE A  41
PHE A 105
GLY A  38
 None
 0.94A 4qogA-1um7A:
undetectable
4qogB-1um7A:
undetectable		 4qogA-1um7A:
20.96
4qogB-1um7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1um7 SYNAPSE-ASSOCIATED
PROTEIN 102
(Homo
sapiens) 		5 / 9 ALA A  95
ILE A  64
GLY A  29
PHE A  30
SER A  44
 None
 1.24A 6awoA-1um7A:
undetectable		 6awoA-1um7A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1um7 SYNAPSE-ASSOCIATED
PROTEIN 102
(Homo
sapiens) 		5 / 9 ALA A  95
ILE A  64
GLY A  29
PHE A  30
SER A  44
 None
 1.25A 6awqA-1um7A:
undetectable		 6awqA-1um7A:
12.34