SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1um8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		5 / 12 LEU A 241
GLU A 246
LEU A 146
LEU A 334
GLY A 332
 None
 1.42A 1d4fB-1um8A:
0.0		 1d4fB-1um8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		5 / 12 LEU A 241
GLU A 246
LEU A 146
LEU A 334
GLY A 332
 None
 1.44A 1d4fD-1um8A:
undetectable		 1d4fD-1um8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		5 / 12 LEU A 321
LEU A 326
GLY A 325
THR A 292
ILE A 288
 None
 1.46A 1p93A-1um8A:
undetectable		 1p93A-1um8A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 7 LEU A 337
GLY A 283
ILE A 287
ILE A 148
 None
 0.79A 2aojB-1um8A:
undetectable		 2aojB-1um8A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 8 ILE A 273
SER A 271
ASP A 269
LEU A 192
 None
 0.90A 2cdqA-1um8A:
undetectable		 2cdqA-1um8A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		3 / 3 HIS A 110
ILE A 276
LEU A 334
 None
 0.66A 2kceA-1um8A:
undetectable		 2kceA-1um8A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		6 / 12 ILE A 216
LEU A 326
ILE A 213
ILE A 327
PRO A 328
VAL A 188
 None
 1.40A 2ygqA-1um8A:
undetectable		 2ygqA-1um8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 5 ILE A 409
PHE A 367
ASP A 373
GLU A 420
 None
 1.13A 3kp6A-1um8A:
0.0
3kp6B-1um8A:
0.0		 3kp6A-1um8A:
19.15
3kp6B-1um8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 7 TYR A 111
ASN A 144
LEU A 274
LYS A 208
 None
 1.21A 3lslA-1um8A:
undetectable
3lslD-1um8A:
undetectable		 3lslA-1um8A:
20.20
3lslD-1um8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 7 TYR A 111
ASN A 144
LEU A 274
LYS A 208
 None
 1.22A 3lslA-1um8A:
undetectable
3lslD-1um8A:
undetectable		 3lslA-1um8A:
20.20
3lslD-1um8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 6 TYR A 111
ASN A 144
LEU A 274
LYS A 208
 None
 1.20A 3lslG-1um8A:
undetectable		 3lslG-1um8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 5 VAL A 237
LEU A 241
ILE A 216
ALA A 175
 None
 0.92A 3n8yB-1um8A:
undetectable		 3n8yB-1um8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		5 / 12 ALA A 358
LEU A 352
ILE A 343
SER A 344
LEU A 398
 None
 1.18A 3nrrA-1um8A:
undetectable		 3nrrA-1um8A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		5 / 12 ALA A 358
LEU A 352
ILE A 343
SER A 344
LEU A 398
 None
 1.20A 3nrrB-1um8A:
undetectable		 3nrrB-1um8A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 5 GLU A 390
LEU A 387
GLN A 386
LYS A 382
 None
 1.25A 3pgyB-1um8A:
0.0		 3pgyB-1um8A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 5 ASP A 269
SER A 248
GLY A 247
ASP A 272
 None
 1.12A 3w9tB-1um8A:
undetectable		 3w9tB-1um8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 5 ASP A 269
SER A 248
GLY A 247
ASP A 272
 None
 1.12A 3w9tC-1um8A:
undetectable		 3w9tC-1um8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 5 ASP A 269
SER A 248
GLY A 247
ASP A 272
 None
 1.11A 3w9tD-1um8A:
undetectable		 3w9tD-1um8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 9 PHE A 405
CYH A 427
PHE A 367
ILE A 436
 None
 1.23A 4jvlA-1um8A:
undetectable		 4jvlA-1um8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 7 ILE A 148
LEU A 321
ASP A 320
THR A 292
 None
 1.12A 4mmcA-1um8A:
0.0		 4mmcA-1um8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		5 / 12 TYR A 111
LEU A 166
LEU A  85
ILE A 276
ILE A 145
 None
 0.90A 4odrA-1um8A:
undetectable
4odrB-1um8A:
undetectable		 4odrA-1um8A:
15.86
4odrB-1um8A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 7 GLN A  96
GLY A 154
ILE A 351
GLN A 362
 None
ADP  A 487 (-2.7A)
ADP  A 487 (-3.9A)
None
 1.07A 5vlmC-1um8A:
undetectable		 5vlmC-1um8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 8 GLN A  96
GLY A 154
ILE A 351
GLN A 362
 None
ADP  A 487 (-2.7A)
ADP  A 487 (-3.9A)
None
 0.98A 5vlmD-1um8A:
undetectable		 5vlmD-1um8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX
(Helicobacter
pylori) 		4 / 5 ILE A 213
SER A 173
ALA A 240
LEU A 330
 None
 1.04A 6dwnA-1um8A:
undetectable		 6dwnA-1um8A:
12.43