SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1umf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 PRO A 325
PHE A 302
SER A 199
THR A 298
ASN A 196
 None
 1.49A 1g60A-1umfA:
undetectable		 1g60A-1umfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 ILE A 194
PRO A 325
PHE A 302
THR A 298
ASN A 196
 None
 1.31A 1g60B-1umfA:
undetectable		 1g60B-1umfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		4 / 7 GLU A 247
MET A 237
PHE A 167
ALA A 328
 None
 1.22A 1linA-1umfA:
undetectable		 1linA-1umfA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		4 / 4 ASP A 345
LEU A  10
LEU A   4
LEU A   8
 None
 1.34A 1u18A-1umfA:
0.0		 1u18A-1umfA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 11 LEU A 143
LEU A 142
VAL A 342
GLY A   5
ARG A   9
 None
 1.44A 1y4lB-1umfA:
undetectable		 1y4lB-1umfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		4 / 8 PHE A 138
VAL A  63
VAL A  69
ILE A  79
 None
 0.96A 2qbmA-1umfA:
undetectable		 2qbmA-1umfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 ALA A 344
LEU A 348
LEU A 217
ILE A 211
PRO A  29
 None
 0.90A 2qxsA-1umfA:
undetectable		 2qxsA-1umfA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 ALA A 344
LEU A 348
LEU A 217
ILE A 211
PRO A  29
 None
 0.86A 2qxsB-1umfA:
undetectable		 2qxsB-1umfA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 8 ALA A 139
LEU A  39
ILE A  79
VAL A  63
ILE A  83
 None
 1.15A 2uxpA-1umfA:
undetectable		 2uxpA-1umfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 10 ASP A  35
ARG A 144
ILE A 148
ILE A 289
GLY A 136
 None
 1.37A 2v0mA-1umfA:
undetectable		 2v0mA-1umfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		3 / 3 PRO A 218
LEU A 217
ARG A 209
 None
 0.90A 3aqiA-1umfA:
undetectable		 3aqiA-1umfA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 10 ALA A 139
ALA A 137
LEU A 341
ALA A 340
ILE A  83
 None
 1.05A 3falC-1umfA:
undetectable		 3falC-1umfA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		3 / 3 ARG A 144
GLU A 151
ASP A 166
 None
 0.89A 3g2oA-1umfA:
undetectable		 3g2oA-1umfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		6 / 10 LEU A   4
ALA A 135
ILE A  79
GLY A  22
ILE A  21
LEU A  10
 None
 1.50A 3ogpA-1umfA:
undetectable		 3ogpA-1umfA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		6 / 10 LEU A   4
ALA A 135
ILE A  79
GLY A  22
ILE A  21
LEU A  10
 None
 1.47A 3ogqA-1umfA:
undetectable		 3ogqA-1umfA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 10 ILE A  83
ASP A  61
ALA A 130
LEU A  10
ILE A 206
 None
 1.14A 3prsA-1umfA:
undetectable		 3prsA-1umfA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.05A 4coxA-1umfA:
undetectable		 4coxA-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.04A 4coxB-1umfA:
undetectable		 4coxB-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.04A 4coxD-1umfA:
undetectable		 4coxD-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 ILE A 160
GLY A 202
GLY A 158
ASP A 324
ILE A 327
 None
 1.08A 4iv0B-1umfA:
undetectable		 4iv0B-1umfA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 VAL A 243
ILE A 206
VAL A 291
ALA A 234
LEU A 339
 None
 1.06A 4m11B-1umfA:
undetectable		 4m11B-1umfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.04A 4otyA-1umfA:
0.0		 4otyA-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 0.99A 4otyB-1umfA:
undetectable		 4otyB-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		4 / 5 HIS A 294
VAL A 246
GLU A 247
VAL A 203
 None
 1.17A 4p6vB-1umfA:
undetectable
4p6vE-1umfA:
0.1		 4p6vB-1umfA:
23.29
4p6vE-1umfA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.00A 4rrwC-1umfA:
undetectable		 4rrwC-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.03A 4rrwD-1umfA:
0.0		 4rrwD-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.10A 4rrxA-1umfA:
undetectable		 4rrxA-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.09A 4rrxB-1umfA:
undetectable		 4rrxB-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.00A 4rrzC-1umfA:
undetectable		 4rrzC-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.03A 4rrzD-1umfA:
0.0		 4rrzD-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 CYH A 335
LEU A 338
THR A 298
VAL A 293
ALA A 204
 None
 1.04A 4x20B-1umfA:
undetectable		 4x20B-1umfA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.19A 5iktB-1umfA:
undetectable		 5iktB-1umfA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		4 / 4 LEU A  25
MET A 141
ILE A 131
LEU A  39
 None
 1.37A 5nfpA-1umfA:
0.0		 5nfpA-1umfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 GLY A 201
GLY A 158
ALA A 189
ASP A 324
ILE A 327
 None
 1.08A 6b3aA-1umfA:
undetectable		 6b3aA-1umfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 12 GLY A 201
GLY A 158
ALA A 189
ASP A 324
ILE A 327
 None
 1.07A 6b3bA-1umfA:
undetectable		 6b3bA-1umfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 9 LEU A 343
GLY A 220
LEU A 221
GLN A 223
VAL A 279
 None
 1.19A 6czmA-1umfA:
undetectable
6czmB-1umfA:
2.0		 6czmA-1umfA:
24.51
6czmB-1umfA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		5 / 9 LEU A 343
GLY A 220
LEU A 221
GLN A 223
VAL A 279
 None
 1.27A 6czmB-1umfA:
2.0
6czmC-1umfA:
undetectable		 6czmB-1umfA:
24.51
6czmC-1umfA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		4 / 8 ILE A 248
VAL A 149
GLU A 151
SER A 152
 None
 0.90A 6fbvC-1umfA:
undetectable		 6fbvC-1umfA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1umf CHORISMATE SYNTHASE
(Helicobacter
pylori) 		4 / 5 GLY A 220
LEU A 221
SER A 353
TYR A 357
 None
 1.05A 6ji6A-1umfA:
undetectable		 6ji6A-1umfA:
20.44