SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1umg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 ASP A  96
GLY A  94
SER A  15
ASP A  54
 MG  A 402 ( 4.2A)
None
MG  A 404 ( 4.3A)
MG  A 403 (-2.6A)
 0.90A 1m4iA-1umgA:
undetectable		 1m4iA-1umgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 ASP A 132
ASP A 233
GLU A 347
GLY A 267
 MG  A 403 ( 2.7A)
MG  A 401 (-2.5A)
MG  A 401 ( 4.0A)
2FP  A 400 (-4.4A)
 0.78A 1m4iA-1umgA:
undetectable		 1m4iA-1umgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.86A 1usqA-1umgA:
undetectable		 1usqA-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 6 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.87A 2jkjA-1umgA:
undetectable		 2jkjA-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 6 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.87A 2jkjB-1umgA:
undetectable		 2jkjB-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 6 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.87A 2jkjC-1umgA:
undetectable		 2jkjC-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.83A 2jklA-1umgA:
undetectable		 2jklA-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 6 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.82A 2jklB-1umgA:
undetectable		 2jklB-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.83A 2jklC-1umgA:
undetectable		 2jklC-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.83A 2jklD-1umgA:
undetectable		 2jklD-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.82A 2jklE-1umgA:
undetectable		 2jklE-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A 110
PRO A 111
ILE A   9
GLY A 112
 None
 0.82A 2jklF-1umgA:
undetectable		 2jklF-1umgA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A 238
ARG A  63
ILE A 126
ALA A  74
 None
 0.70A 2nniA-1umgA:
undetectable		 2nniA-1umgA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 12 ARG A 121
LEU A 212
ILE A 202
ILE A 238
LEU A 245
 None
 0.94A 2o4nA-1umgA:
undetectable		 2o4nA-1umgA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 10 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
 None
 1.20A 3lxiA-1umgA:
undetectable		 3lxiA-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 11 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
 None
 1.19A 3lxiB-1umgA:
undetectable		 3lxiB-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 6 PHE A 129
LEU A 248
ALA A 254
THR A 153
 None
 0.96A 3t3zD-1umgA:
undetectable		 3t3zD-1umgA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 5 LEU A 248
GLY A 249
PHE A 311
ASN A 152
 None
 1.22A 3uq6B-1umgA:
undetectable		 3uq6B-1umgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 12 PHE A 255
PRO A 142
LEU A 143
VAL A 217
ALA A 131
 None
 1.47A 4a84A-1umgA:
2.1		 4a84A-1umgA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 5 HIS A  19
SER A  15
GLN A  95
VAL A  22
 MG  A 404 ( 3.3A)
MG  A 404 ( 4.3A)
MG  A 404 ( 2.7A)
None
 1.34A 4a99D-1umgA:
undetectable		 4a99D-1umgA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 9 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
 None
 1.25A 4c9kA-1umgA:
undetectable		 4c9kA-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 9 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
 None
 1.22A 4c9kB-1umgA:
undetectable		 4c9kB-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 9 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
 None
 1.21A 4c9pA-1umgA:
0.0		 4c9pA-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 10 THR A  49
LEU A 292
LEU A 293
GLY A 294
VAL A   8
 None
 1.18A 4c9pB-1umgA:
undetectable		 4c9pB-1umgA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 VAL A  33
LEU A  34
ILE A  58
VAL A 113
 None
 0.93A 4ma7A-1umgA:
undetectable		 4ma7A-1umgA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		3 / 3 LEU A  55
ASP A  53
ILE A  58
 None
MG  A 403 (-2.7A)
None
 0.65A 4xi3D-1umgA:
undetectable		 4xi3D-1umgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		3 / 3 LEU A 213
ASP A 210
ILE A 202
 None
 0.60A 4xi3D-1umgA:
undetectable		 4xi3D-1umgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 4 LEU A 241
LEU A 252
GLY A 249
GLU A 250
 None
 1.26A 5hhjA-1umgA:
0.5		 5hhjA-1umgA:
21.56