SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1unl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1
(Homo
sapiens) 		3 / 3 THR D 148
LEU D 152
LEU D 159
 None
 0.63A 1mz9C-1unlD:
undetectable		 1mz9C-1unlD:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1
(Homo
sapiens) 		4 / 8 THR D 228
CYH D 208
TRP D 177
LEU D 204
 None
 1.44A 1uw6A-1unlD:
undetectable
1uw6B-1unlD:
undetectable		 1uw6A-1unlD:
22.51
1uw6B-1unlD:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1
(Homo
sapiens) 		4 / 8 THR D 228
CYH D 208
TRP D 177
LEU D 204
 None
 1.49A 1uw6G-1unlD:
undetectable
1uw6H-1unlD:
undetectable		 1uw6G-1unlD:
22.51
1uw6H-1unlD:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1
(Homo
sapiens) 		4 / 8 THR D 228
CYH D 208
TRP D 177
LEU D 204
 None
 1.42A 1uw6P-1unlD:
undetectable
1uw6Q-1unlD:
undetectable		 1uw6P-1unlD:
22.51
1uw6Q-1unlD:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1
(Homo
sapiens) 		5 / 12 LEU D 152
LEU D 155
LEU D 159
ILE D 196
VAL D 216
 None
 1.02A 2pnjA-1unlD:
undetectable		 2pnjA-1unlD:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1
(Homo
sapiens) 		4 / 4 PRO D 174
LEU D 222
ILE D 212
ARG D 162
 None
 1.36A 3w1wA-1unlD:
undetectable		 3w1wA-1unlD:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1
(Homo
sapiens) 		4 / 8 LEU D 152
LEU D 155
LEU D 159
ILE D 196
 None
 0.57A 4klaA-1unlD:
undetectable		 4klaA-1unlD:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1
(Homo
sapiens) 		4 / 7 PHE D 248
LEU D 227
SER D 233
VAL D 181
 None
 1.06A 4wnvD-1unlD:
undetectable		 4wnvD-1unlD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1
(Homo
sapiens) 		3 / 3 LEU D 155
LEU D 226
ARG D 183
 None
 0.56A 5hnzB-1unlD:
undetectable		 5hnzB-1unlD:
18.88