SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 11 ILE A 184
VAL A 185
CYH A 182
LEU A 177
ILE A 143
 None
 1.28A 1pkvA-1uouA:
undetectable
1pkvB-1uouA:
undetectable		 1pkvA-1uouA:
10.50
1pkvB-1uouA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 7 GLY A 186
ARG A 146
ILE A 167
VAL A 166
 None
 1.07A 1rxcF-1uouA:
undetectable		 1rxcF-1uouA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 334
ALA A 327
GLN A 323
LEU A 309
LEU A 133
 None
 1.48A 1ya3B-1uouA:
undetectable		 1ya3B-1uouA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 262
ALA A  94
LEU A  95
SER A 220
VAL A 224
 None
 1.24A 2c12C-1uouA:
0.0		 2c12C-1uouA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 GLY A 405
GLY A 149
GLY A 147
VAL A 208
THR A 207
 None
None
CMU  A1481 ( 4.9A)
None
None
 0.98A 2wa2A-1uouA:
undetectable		 2wa2A-1uouA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 VAL A 427
ASP A 426
THR A 271
GLY A 278
LEU A 277
 None
 1.22A 3j6pB-1uouA:
undetectable		 3j6pB-1uouA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 6 GLY A 186
ARG A 146
ILE A 167
VAL A 166
 None
 1.11A 3kvvA-1uouA:
3.9		 3kvvA-1uouA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 6 GLY A 186
ARG A 146
ILE A 167
VAL A 166
 None
 1.17A 3kvvE-1uouA:
2.1		 3kvvE-1uouA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 6 GLY A 186
ARG A 146
ILE A 167
VAL A 166
 None
 1.15A 3kvvF-1uouA:
3.6		 3kvvF-1uouA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 8 ALA A 284
VAL A 287
LEU A 291
LEU A 371
 None
 0.60A 3roxA-1uouA:
undetectable		 3roxA-1uouA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 THR A 154
GLY A 145
GLY A 186
GLU A 225
LEU A 227
 None
 1.09A 3t7vA-1uouA:
undetectable		 3t7vA-1uouA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 4 LEU A 155
GLY A 153
MET A 142
PHE A 164
 None
CMU  A1481 ( 4.1A)
None
None
 1.21A 3vaqB-1uouA:
1.9		 3vaqB-1uouA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 334
ALA A 327
GLN A 323
LEU A 309
LEU A 133
 None
 1.47A 3vhuA-1uouA:
undetectable		 3vhuA-1uouA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 6 GLY A 186
ARG A 146
ILE A 167
VAL A 166
 None
 1.11A 4e1vF-1uouA:
3.6		 4e1vF-1uouA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 ARG A  48
GLU A  87
GLY A  47
ARG A  81
VAL A 258
 None
 1.29A 4ffwA-1uouA:
2.3		 4ffwA-1uouA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		3 / 3 GLU A 422
ARG A 439
HIS A 441
 None
 0.71A 4kf9A-1uouA:
undetectable		 4kf9A-1uouA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 11 GLY A 326
GLY A 311
GLY A 310
ALA A 320
LEU A 314
 None
 1.01A 4l8fB-1uouA:
undetectable		 4l8fB-1uouA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 11 GLY A 326
GLY A 311
GLY A 310
ALA A 320
LEU A 314
 None
 1.04A 4l8fD-1uouA:
undetectable		 4l8fD-1uouA:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		6 / 11 ARG A 202
VAL A 208
ILE A 214
SER A 217
LYS A 221
LEU A 251
 CMU  A1481 (-2.8A)
None
CMU  A1481 (-3.9A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
 0.32A 4lhmA-1uouA:
49.0		 4lhmA-1uouA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 11 THR A 118
TYR A 199
SER A 217
LYS A 221
LEU A 251
 None
CMU  A1481 (-4.7A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
 1.07A 4lhmA-1uouA:
49.0		 4lhmA-1uouA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		6 / 11 TYR A 199
ARG A 202
ILE A 214
SER A 217
LYS A 221
LEU A 251
 CMU  A1481 (-4.7A)
CMU  A1481 (-2.8A)
CMU  A1481 (-3.9A)
CMU  A1481 (-2.7A)
CMU  A1481 (-2.6A)
None
 0.66A 4lhmA-1uouA:
49.0		 4lhmA-1uouA:
38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 6 SER A 169
GLU A 171
GLY A 163
GLY A 351
 None
 0.94A 5cdnC-1uouA:
2.3
5cdnD-1uouA:
3.0		 5cdnC-1uouA:
21.88
5cdnD-1uouA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 6 SER A 169
GLU A 171
GLY A 163
GLY A 351
 None
 0.92A 5cdnT-1uouA:
2.2
5cdnU-1uouA:
2.5		 5cdnT-1uouA:
21.88
5cdnU-1uouA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 127
GLY A 152
ASP A 156
GLY A 145
HIS A 283
 None
 1.19A 5nnaA-1uouA:
undetectable		 5nnaA-1uouA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 127
GLY A 152
ASP A 156
GLY A 145
HIS A 283
 None
 1.17A 5nnaD-1uouA:
undetectable		 5nnaD-1uouA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 334
GLY A 310
ALA A 132
LYS A 115
THR A 308
 None
 1.23A 5x6yC-1uouA:
0.6		 5x6yC-1uouA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		4 / 5 HIS A 116
SER A 144
GLY A 145
TYR A 199
 CMU  A1481 (-4.3A)
None
None
CMU  A1481 (-4.7A)
 1.45A 5yodH-1uouA:
undetectable		 5yodH-1uouA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 GLY A 147
GLY A 149
SER A 117
VAL A 121
GLY A 153
 CMU  A1481 ( 4.9A)
None
CMU  A1481 (-4.3A)
None
CMU  A1481 ( 4.1A)
 0.86A 5zhmB-1uouA:
2.2		 5zhmB-1uouA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 12 LEU A 476
VAL A 256
VAL A 232
PRO A 480
LEU A 478
 None
 1.20A 6eliA-1uouA:
1.3		 6eliA-1uouA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1uou THYMIDINE
PHOSPHORYLASE
(Homo
sapiens) 		5 / 10 LEU A 395
LEU A 423
GLY A 119
GLY A 278
VAL A 281
 None
None
CMU  A1481 ( 3.8A)
None
None
 1.21A 6eu9B-1uouA:
0.0		 6eu9B-1uouA:
8.86