SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1up4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 12 GLY A   7
GLY A   9
ILE A  37
ASP A  38
ILE A 119
 None
 0.78A 1qaoA-1up4A:
2.5		 1qaoA-1up4A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 10 ILE A   6
ALA A   4
ALA A  68
ALA A  72
ILE A 119
 None
 1.14A 2aclC-1up4A:
undetectable		 2aclC-1up4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 ALA A 384
THR A 369
ALA A 372
ARG A 376
 None
 0.98A 2ql8A-1up4A:
undetectable
2ql8B-1up4A:
undetectable		 2ql8A-1up4A:
17.12
2ql8B-1up4A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 8 ASN A 239
VAL A 164
TYR A 245
ASN A 316
 None
 1.25A 2wekA-1up4A:
3.2		 2wekA-1up4A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 8 ASN A 239
VAL A 164
TYR A 245
ASN A 316
 None
 1.23A 2wekB-1up4A:
3.3		 2wekB-1up4A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 12 GLY A   7
LEU A  16
ASP A  36
ILE A  37
ASP A  38
 None
 0.93A 3cjtC-1up4A:
3.7		 3cjtC-1up4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 12 GLY A   7
GLY A   9
LEU A  16
ILE A  37
ASP A  38
 None
 0.99A 3cjtO-1up4A:
3.6		 3cjtO-1up4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 12 LEU A  20
PHE A  34
ALA A  72
VAL A 136
ILE A 302
 None
 1.00A 3czhB-1up4A:
undetectable		 3czhB-1up4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 10 ILE A  76
GLY A 160
TYR A 155
VAL A 127
LEU A 305
 None
 1.16A 3elzC-1up4A:
undetectable		 3elzC-1up4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 12 ALA A 113
GLY A 109
LEU A 114
GLY A 143
GLU A 366
 None
 1.10A 3g2oB-1up4A:
3.8		 3g2oB-1up4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 8 ARG A 128
SER A 131
VAL A 120
LEU A 153
 None
 1.12A 3jq7C-1up4A:
7.2		 3jq7C-1up4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 TYR A 245
GLU A 366
LEU A 242
ASN A 239
 None
 1.40A 3k8mB-1up4A:
undetectable		 3k8mB-1up4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 8 GLY A 108
CYH A 162
PHE A  77
PHE A 158
 None
 1.05A 3ko0B-1up4A:
undetectable
3ko0J-1up4A:
undetectable		 3ko0B-1up4A:
14.17
3ko0J-1up4A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		3 / 3 ASN A 167
ASN A 239
GLU A 333
 None
 0.91A 3kpdC-1up4A:
undetectable		 3kpdC-1up4A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		3 / 3 ASN A 167
ASN A 239
GLU A 333
 None
 0.94A 3kpdB-1up4A:
undetectable		 3kpdB-1up4A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 12 VAL A 120
ILE A 145
GLY A 160
ILE A 159
VAL A 124
 None
 0.86A 3so9B-1up4A:
undetectable		 3so9B-1up4A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 10 VAL A 120
ILE A 145
GLY A 160
ILE A 159
VAL A 124
 None
 0.84A 3t3cB-1up4A:
undetectable		 3t3cB-1up4A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 6 THR A 104
GLY A 106
ARG A 243
ILE A 100
 None
 1.11A 4ac9C-1up4A:
4.6		 4ac9C-1up4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 6 THR A 104
GLY A 106
ARG A 243
ILE A 100
 None
 1.10A 4acaC-1up4A:
4.0		 4acaC-1up4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 6 THR A 104
GLY A 106
ARG A 243
ILE A 100
 None
 1.04A 4acbC-1up4A:
4.4		 4acbC-1up4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 6 GLN A  78
THR A 104
HIS A 192
ASN A 137
 None
 1.32A 4pfjB-1up4A:
6.0		 4pfjB-1up4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 ALA A 299
SER A 295
ILE A 166
LEU A 161
 None
 0.96A 4uymA-1up4A:
undetectable		 4uymA-1up4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 5 GLY A  67
TYR A 123
TYR A  35
GLY A   7
 None
 1.03A 5ayfA-1up4A:
undetectable		 5ayfA-1up4A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 ASP A  22
THR A 287
GLU A  15
ARG A 303
 None
 1.00A 5bs8A-1up4A:
undetectable
5bs8B-1up4A:
0.8
5bs8C-1up4A:
undetectable		 5bs8A-1up4A:
22.62
5bs8B-1up4A:
19.72
5bs8C-1up4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 ARG A 303
ASP A  22
THR A 287
GLU A  15
 None
 0.96A 5btaA-1up4A:
0.0
5btaC-1up4A:
0.0
5btaD-1up4A:
undetectable		 5btaA-1up4A:
22.62
5btaC-1up4A:
22.62
5btaD-1up4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 ASP A  22
THR A 287
GLU A  15
ARG A 303
 None
 0.99A 5btdA-1up4A:
0.0
5btdB-1up4A:
1.7
5btdC-1up4A:
0.0		 5btdA-1up4A:
22.62
5btdB-1up4A:
19.72
5btdC-1up4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 ARG A 303
ASP A  22
THR A 287
GLU A  15
 None
 0.96A 5btdA-1up4A:
0.0
5btdC-1up4A:
0.0
5btdD-1up4A:
1.5		 5btdA-1up4A:
22.62
5btdC-1up4A:
22.62
5btdD-1up4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 ASP A  22
THR A 287
GLU A  15
ARG A 303
 None
 0.95A 5btfA-1up4A:
0.0
5btfB-1up4A:
1.5
5btfC-1up4A:
0.0		 5btfA-1up4A:
22.62
5btfB-1up4A:
19.72
5btfC-1up4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 ARG A 303
ASP A  22
THR A 287
GLU A  15
 None
 0.92A 5btfA-1up4A:
0.0
5btfC-1up4A:
0.0
5btfD-1up4A:
1.6		 5btfA-1up4A:
22.62
5btfC-1up4A:
22.62
5btfD-1up4A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 12 LEU A 286
VAL A  45
TYR A  12
PHE A 273
LEU A 272
 None
 1.27A 5cyqA-1up4A:
undetectable		 5cyqA-1up4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 6 TYR A  74
TYR A 155
GLY A 341
ASP A 308
 None
 1.25A 5emlA-1up4A:
undetectable		 5emlA-1up4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 5 TYR A 187
LEU A 242
PRO A 240
LEU A 190
 None
 1.46A 5eshA-1up4A:
0.0		 5eshA-1up4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 8 ILE A 166
PRO A 165
ILE A 159
TYR A 294
 None
 0.94A 5ieoA-1up4A:
0.0		 5ieoA-1up4A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 9 ILE A 237
LEU A 214
GLU A 171
ARG A 170
ILE A 172
 None
 1.46A 5ifuB-1up4A:
undetectable		 5ifuB-1up4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 7 LEU A 193
TYR A 241
LEU A 242
TYR A 245
 None
 0.99A 5t7bA-1up4A:
2.2		 5t7bA-1up4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 12 GLY A   7
GLY A   9
ASP A  36
ILE A  37
LYS A  41
 None
 0.67A 5wy0A-1up4A:
3.7		 5wy0A-1up4A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11801_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		4 / 4 ARG A 261
ARG A  87
GLY A  86
ARG A 115
 None
 1.32A 6az3P-1up4A:
undetectable		 6az3P-1up4A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 10 LEU A 414
ALA A 381
TYR A 373
PRO A 118
GLU A 122
 None
 1.04A 6b89A-1up4A:
0.0		 6b89A-1up4A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1up4 6-PHOSPHO-BETA-GLUCO
SIDASE
(Thermotoga
maritima) 		5 / 12 ILE A   6
GLY A   7
GLY A   9
ILE A  37
ASP A  38
 None
 0.77A 6iftA-1up4A:
3.0		 6iftA-1up4A:
22.43