SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1upf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 LEU D 196
ASN D 194
LEU D 223
PHE D 192
MET D 214
 None
 1.38A 1a28A-1upfD:
undetectable		 1a28A-1upfD:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 ILE D  29
ALA D 197
ILE D 229
GLN D 200
ILE D  25
 None
None
URF  D 999 (-4.0A)
None
None
 0.99A 1df7A-1upfD:
undetectable		 1df7A-1upfD:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 9 VAL D 108
LEU D 151
ILE D 135
ALA D 176
LEU D 180
 None
 1.17A 1eqgA-1upfD:
0.0		 1eqgA-1upfD:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 PRO D 165
SER D 116
LEU D 196
LEU D  73
ILE D 233
 None
 1.46A 1lbcA-1upfD:
undetectable
1lbcC-1upfD:
undetectable		 1lbcA-1upfD:
19.15
1lbcC-1upfD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 ILE D 233
PRO D 165
SER D 116
LEU D 196
LEU D  73
 None
 1.34A 1lbcA-1upfD:
undetectable
1lbcC-1upfD:
undetectable		 1lbcA-1upfD:
19.15
1lbcC-1upfD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 8 ALA D 218
ILE D 229
GLY D 232
ILE D  52
PRO D 165
 None
URF  D 999 (-4.0A)
None
None
None
 1.12A 1sguA-1upfD:
undetectable		 1sguA-1upfD:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		4 / 6 PHE D 192
VAL D 173
MET D 117
SER D 116
 None
 0.96A 1wrlB-1upfD:
undetectable		 1wrlB-1upfD:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 11 PRO D 165
SER D 116
LEU D 196
LEU D  73
ILE D 233
 None
 1.37A 3h6tA-1upfD:
undetectable
3h6tC-1upfD:
undetectable		 3h6tA-1upfD:
19.15
3h6tC-1upfD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 11 ILE D 233
PRO D 165
SER D 116
LEU D 196
LEU D  73
 None
 1.41A 3h6tA-1upfD:
undetectable
3h6tC-1upfD:
undetectable		 3h6tA-1upfD:
19.15
3h6tC-1upfD:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 10 ILE D 233
PRO D 165
SER D 116
LEU D 196
LEU D  73
 None
 1.45A 3iltB-1upfD:
undetectable
3iltE-1upfD:
undetectable		 3iltB-1upfD:
19.71
3iltE-1upfD:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 GLY D 114
LEU D 163
PHE D 236
ALA D  66
ASP D  67
 None
 1.11A 3tbgD-1upfD:
0.0		 3tbgD-1upfD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		4 / 6 PRO D 231
GLY D 232
LEU D 196
GLU D  22
 None
 1.00A 3zqtA-1upfD:
undetectable		 3zqtA-1upfD:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		3 / 3 TYR D 227
ARG D 226
SER D 225
 None
 0.91A 4khpI-1upfD:
undetectable
4khpJ-1upfD:
undetectable		 4khpI-1upfD:
25.25
4khpJ-1upfD:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		5 / 12 ILE D  29
ALA D 197
ILE D 229
GLN D 200
ILE D  25
 None
None
URF  D 999 (-4.0A)
None
None
 1.10A 4m2xG-1upfD:
undetectable		 4m2xG-1upfD:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1upf URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Toxoplasma
gondii) 		3 / 3 ASN D 194
ASP D 220
GLY D 232
 None
 0.65A 5fctB-1upfD:
undetectable		 5fctB-1upfD:
22.37