SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1upn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		4 / 8 VAL C  55
VAL C  53
SER C  51
LEU C 116
 None
 0.91A 1igxA-1upnC:
undetectable		 1igxA-1upnC:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		3 / 3 ASP C  50
ILE C 168
VAL C  94
 None
 0.67A 2avvD-1upnC:
undetectable		 2avvD-1upnC:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		3 / 3 LYS C 226
GLY C  90
PRO C  89
 None
 0.85A 2hreB-1upnC:
undetectable		 2hreB-1upnC:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		4 / 5 PHE C  95
PHE C  85
PHE C  83
VAL C 214
 None
 1.15A 2lh6A-1upnC:
undetectable		 2lh6A-1upnC:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		4 / 7 ILE C 114
LEU C 104
GLY C 101
PHE C  95
 None
 0.89A 4iqqA-1upnC:
undetectable		 4iqqA-1upnC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		4 / 8 ILE C 114
LEU C 104
GLY C 101
PHE C  95
 None
 0.79A 4iqqD-1upnC:
undetectable		 4iqqD-1upnC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		5 / 12 PHE C 130
GLY C 122
ALA C 126
CYH C 208
ILE C 198
 None
 1.15A 4krhB-1upnC:
undetectable		 4krhB-1upnC:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		3 / 3 LEU C 224
LEU C  43
ASN C 105
 None
 0.70A 4otwA-1upnC:
undetectable		 4otwA-1upnC:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		3 / 3 ASP C  66
ASN C  57
PHE C  83
 None
 0.75A 5dsgB-1upnC:
undetectable		 5dsgB-1upnC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		4 / 7 ILE C 114
LEU C 104
GLY C 101
PHE C  95
 None
 0.77A 5nooB-1upnC:
undetectable		 5nooB-1upnC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1upn ECHOVIRUS 11 COAT
PROTEIN VP3
(Enterovirus
B) 		4 / 8 ILE C 114
LEU C 104
GLY C 101
PHE C  95
 None
 0.74A 5nooD-1upnC:
undetectable		 5nooD-1upnC:
20.42