SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1upr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		4 / 8 ARG A1075
LYS A1063
SER A1098
ARG A1129
 4IP  A2154 (-3.6A)
4IP  A2154 (-2.5A)
None
4IP  A2154 (-2.5A)
 1.20A 1u1jA-1uprA:
undetectable		 1u1jA-1uprA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		5 / 12 ALA A1147
LEU A1084
LEU A1079
LEU A1133
LEU A1101
 None
 1.16A 1xdkB-1uprA:
0.0		 1xdkB-1uprA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		3 / 3 ASP A1065
ARG A1075
LYS A1063
 4IP  A2154 (-3.7A)
4IP  A2154 (-3.6A)
4IP  A2154 (-2.5A)
 1.24A 3wipG-1uprA:
undetectable		 3wipG-1uprA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		5 / 12 ASP A1065
TRP A1072
THR A1122
THR A1120
ALA A1134
 4IP  A2154 (-3.7A)
None
None
None
None
 1.36A 4dajB-1uprA:
undetectable		 4dajB-1uprA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		5 / 12 ASP A1065
TRP A1072
THR A1122
THR A1120
ALA A1134
 4IP  A2154 (-3.7A)
None
None
None
None
 1.45A 4u15A-1uprA:
undetectable		 4u15A-1uprA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1upr PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 4
(Homo
sapiens) 		5 / 12 ASP A1065
TRP A1072
THR A1122
THR A1120
ALA A1134
 4IP  A2154 (-3.7A)
None
None
None
None
 1.47A 5dsgA-1uprA:
undetectable		 5dsgA-1uprA:
14.01