SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ups'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		4 / 7 TYR A 335
GLN A 195
THR A 199
SER A 197
 None
 1.11A 1eiiA-1upsA:
undetectable		 1eiiA-1upsA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		4 / 8 VAL A 151
ASP A 170
HIS A 107
LEU A  53
 None
 1.22A 1pk2A-1upsA:
undetectable		 1pk2A-1upsA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		4 / 6 LEU A 303
LEU A 416
TRP A 414
PHE A 381
 None
 1.43A 1ru9H-1upsA:
undetectable
1ru9L-1upsA:
undetectable		 1ru9H-1upsA:
19.44
1ru9L-1upsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		4 / 7 ILE A 238
LEU A 226
PHE A 228
ARG A 183
 None
 1.02A 3ag4N-1upsA:
undetectable
3ag4W-1upsA:
undetectable		 3ag4N-1upsA:
19.44
3ag4W-1upsA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		5 / 12 ALA A  22
ILE A 216
ASP A 272
PHE A  34
LEU A  32
 None
None
CA  A 501 (-3.3A)
None
None
 1.33A 3cl9A-1upsA:
undetectable		 3cl9A-1upsA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		5 / 12 PRO A  54
TRP A  56
ILE A 106
MET A 153
SER A 100
 None
 1.46A 3g4lD-1upsA:
undetectable		 3g4lD-1upsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		3 / 3 LYS A 227
ILE A 294
PHE A 302
 None
 0.98A 3j7zS-1upsA:
undetectable
3j7za-1upsA:
undetectable		 3j7zS-1upsA:
14.94
3j7za-1upsA:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		3 / 3 LYS A 103
SER A 163
GLN A 154
 None
 0.92A 3si7A-1upsA:
undetectable		 3si7A-1upsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		3 / 3 TYR A  67
GLN A  82
TRP A 269
 None
 0.89A 4kn2C-1upsA:
undetectable		 4kn2C-1upsA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		4 / 5 ASN A  66
TYR A  67
ILE A  98
ARG A  45
 None
 1.49A 4o0oA-1upsA:
undetectable		 4o0oA-1upsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		4 / 6 SER A 138
GLY A 143
ASN A 262
ILE A  78
 None
 1.16A 5j4nA-1upsA:
undetectable		 5j4nA-1upsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		4 / 8 TRP A 221
THR A 125
TYR A 124
THR A 248
 None
 1.30A 5tzoB-1upsA:
4.0		 5tzoB-1upsA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE
(Clostridium
perfringens) 		4 / 7 GLN A 146
GLY A 144
ILE A  78
ASP A 255
 None
 1.16A 5vlmC-1upsA:
undetectable		 5vlmC-1upsA:
16.35