SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 1uqr 3-DEHYDROQUINATE
DEHYDRATASE
(Actinobacillus
pleuropneumoniae) 		4 / 4 LYS A  17
LEU A  15
LEU A  28
SER A  29
 None
 1.45A 1tz8D-1uqrA:
0.0		 1tz8D-1uqrA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 1uqr 3-DEHYDROQUINATE
DEHYDRATASE
(Actinobacillus
pleuropneumoniae) 		5 / 9 GLY A  53
ALA A  51
SER A  56
LEU A  57
LEU A   7
 SO4  A1147 (-3.5A)
None
None
None
None
 1.43A 1y7iA-1uqrA:
4.7		 1y7iA-1uqrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 1uqr 3-DEHYDROQUINATE
DEHYDRATASE
(Actinobacillus
pleuropneumoniae) 		5 / 10 ILE A  31
ASN A   8
LEU A   6
VAL A  99
ILE A   4
 None
 1.23A 2nnhB-1uqrA:
undetectable		 2nnhB-1uqrA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1uqr 3-DEHYDROQUINATE
DEHYDRATASE
(Actinobacillus
pleuropneumoniae) 		5 / 12 ILE A  97
ALA A 139
THR A  68
VAL A  92
LEU A   7
 None
 1.31A 4qzuA-1uqrA:
undetectable		 4qzuA-1uqrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 1uqr 3-DEHYDROQUINATE
DEHYDRATASE
(Actinobacillus
pleuropneumoniae) 		5 / 12 ASN A   8
GLY A 131
GLY A 128
VAL A  99
ILE A  72
 None
 1.03A 6ectA-1uqrA:
undetectable		 6ectA-1uqrA:
19.57