SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		5 / 12 PRO A 222
GLY A  12
SER A  13
ALA A 218
ALA A  10
 None
 1.04A 1nw5A-1uqwA:
undetectable		 1nw5A-1uqwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 8 VAL A  86
ASP A  91
THR A  66
LEU A  69
 None
 0.98A 1z2bB-1uqwA:
undetectable		 1z2bB-1uqwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		5 / 12 LEU A  42
ALA A 388
ILE A 243
ILE A 295
ALA A 296
 None
None
None
None
GOL  A 551 (-3.4A)
 0.94A 2bxcA-1uqwA:
undetectable		 2bxcA-1uqwA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		3 / 3 PHE A 481
VAL A   9
TRP A 197
 None
 0.82A 2cc8A-1uqwA:
undetectable		 2cc8A-1uqwA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		3 / 3 PHE A 481
VAL A   9
TRP A 197
 None
 0.80A 2ccbA-1uqwA:
undetectable		 2ccbA-1uqwA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 5 LEU A 397
VAL A 262
LEU A 266
ARG A 380
 None
 1.09A 2oiqA-1uqwA:
undetectable		 2oiqA-1uqwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		3 / 3 PHE A 481
VAL A   9
TRP A 197
 None
 0.80A 2vx9A-1uqwA:
undetectable		 2vx9A-1uqwA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 4 ALA A 298
TYR A 297
ALA A 396
TYR A 441
 None
 1.30A 2wlkA-1uqwA:
undetectable
2wlkB-1uqwA:
undetectable		 2wlkA-1uqwA:
19.65
2wlkB-1uqwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		6 / 9 ALA A 311
VAL A 262
VAL A 351
GLY A 352
GLY A 323
ALA A 269
 None
 1.42A 2z0yB-1uqwA:
undetectable		 2z0yB-1uqwA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 4 PRO A 190
TYR A 165
GLY A 163
THR A 162
 None
 1.00A 3ib0A-1uqwA:
4.2		 3ib0A-1uqwA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 7 GLY A 156
PRO A 159
GLY A 161
THR A 162
 None
 0.86A 3tajA-1uqwA:
4.1		 3tajA-1uqwA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		5 / 11 TYR A 247
LEU A 397
ILE A 295
GLN A 245
PHE A 401
 None
 1.43A 4a7aA-1uqwA:
undetectable		 4a7aA-1uqwA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 5 LEU A 488
ILE A 195
ALA A 486
PHE A 473
 None
 1.00A 4dc3B-1uqwA:
undetectable		 4dc3B-1uqwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 4 THR A 205
ARG A 198
GLU A 214
VAL A 200
 None
ZN  A 505 ( 4.2A)
ZN  A 505 (-2.2A)
None
 1.23A 4odoC-1uqwA:
0.0		 4odoC-1uqwA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 4 ASN A  82
SER A 144
ALA A  85
VAL A  86
 None
 1.19A 4x1kC-1uqwA:
undetectable		 4x1kC-1uqwA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		5 / 12 PHE A  81
GLY A  38
ILE A 143
PRO A 145
THR A 162
 None
 0.96A 4xdrA-1uqwA:
1.7		 4xdrA-1uqwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		3 / 3 PHE A 481
ILE A 475
ASP A  43
 None
 0.76A 5cswA-1uqwA:
1.4		 5cswA-1uqwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		3 / 3 PHE A 481
ILE A 475
ASP A  43
 None
 0.72A 5cswB-1uqwA:
undetectable		 5cswB-1uqwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 6 VAL A 421
VAL A 290
ARG A 263
ILE A 455
 None
 1.05A 5jw1B-1uqwA:
undetectable		 5jw1B-1uqwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 4 ASN A  82
SER A 144
ALA A  85
VAL A  86
 None
 0.94A 5nm5A-1uqwA:
undetectable		 5nm5A-1uqwA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 8 THR A  17
ASP A 174
VAL A  11
GLY A  12
 None
 1.02A 5nzyA-1uqwA:
undetectable		 5nzyA-1uqwA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		4 / 8 ASP A  25
THR A  26
LEU A  27
THR A  16
 None
 1.25A 5ov9B-1uqwA:
undetectable		 5ov9B-1uqwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		5 / 12 GLY A  38
SER A 389
ASP A 394
ALA A 130
PHE A 128
 None
 1.07A 5zvgA-1uqwA:
undetectable		 5zvgA-1uqwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1uqw PUTATIVE BINDING
PROTEIN YLIB
(Escherichia
coli) 		5 / 12 GLY A  38
SER A 389
ASP A 394
ALA A 130
PHE A 128
 None
 1.08A 5zvgB-1uqwA:
undetectable		 5zvgB-1uqwA:
22.62