SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1urh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		3 / 3 TRP A   4
VAL A   6
TRP A 104
 None
 1.23A 1c4dA-1urhA:
undetectable
1c4dB-1urhA:
undetectable		 1c4dA-1urhA:
4.92
1c4dB-1urhA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A 178
ALA A 181
ASP A 184
GLY A 193
 None
 1.13A 1e7bA-1urhA:
0.0		 1e7bA-1urhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		4 / 5 ARG A 178
ALA A 181
ASP A 184
GLY A 193
 None
 1.23A 1e7cA-1urhA:
undetectable		 1e7cA-1urhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		4 / 8 HIS A  45
TYR A  92
LEU A  42
GLU A 138
 None
 1.12A 1i7zA-1urhA:
undetectable		 1i7zA-1urhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		4 / 8 SER A  58
ASP A  93
PHE A  52
MET A  27
 None
 1.09A 1lhvA-1urhA:
undetectable		 1lhvA-1urhA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		4 / 6 ASP A 262
GLY A 263
PRO A  65
SER A  62
 None
 0.95A 1n4fA-1urhA:
undetectable		 1n4fA-1urhA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 122
GLY A  95
ILE A  46
VAL A  91
GLY A 121
 None
 0.82A 1uakA-1urhA:
undetectable		 1uakA-1urhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		6 / 12 GLY A 120
GLY A 124
GLU A 211
ILE A  90
HIS A  88
VAL A   6
 None
 1.19A 2oxtB-1urhA:
undetectable		 2oxtB-1urhA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 12 VAL A 246
LEU A 247
ILE A 117
PRO A 101
PHE A  98
 None
 1.26A 3bjwF-1urhA:
undetectable		 3bjwF-1urhA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		3 / 3 GLY A 210
GLY A 124
GLY A 120
 None
 0.40A 3bogD-1urhA:
undetectable		 3bogD-1urhA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		3 / 3 THR A  73
ASP A  59
GLU A 267
 None
 0.75A 3qowA-1urhA:
undetectable		 3qowA-1urhA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A 120
GLY A 119
PHE A   5
GLY A  95
ASP A  93
 None
 0.92A 3ztvA-1urhA:
undetectable		 3ztvA-1urhA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 10 LEU A 132
GLY A 121
TYR A  92
ASP A  93
GLY A  95
 None
 1.20A 4bwlC-1urhA:
undetectable		 4bwlC-1urhA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A 120
GLY A 119
PHE A   5
GLY A  95
ASP A  93
 None
 0.93A 4h2fA-1urhA:
undetectable		 4h2fA-1urhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A 120
GLY A 119
PHE A   5
GLY A  95
ASP A  93
 None
 1.01A 4h2gA-1urhA:
undetectable		 4h2gA-1urhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A 121
GLY A 119
PHE A   5
GLY A  95
ASP A  93
 None
 1.36A 4h2gA-1urhA:
undetectable		 4h2gA-1urhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 9 GLY A 210
GLY A 120
PHE A   5
GLY A  95
ASP A  93
 None
 1.42A 4h2gA-1urhA:
undetectable		 4h2gA-1urhA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 11 ILE A  54
ALA A  56
LEU A  81
PHE A  52
LEU A 107
 None
 1.33A 4i1nA-1urhA:
undetectable		 4i1nA-1urhA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 8 ALA A 168
VAL A 159
GLY A 197
VAL A 235
ILE A 234
 None
 1.30A 4ll3A-1urhA:
undetectable		 4ll3A-1urhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		4 / 8 LEU A 253
LEU A 212
THR A 215
LEU A 218
 None
 0.76A 4z90F-1urhA:
0.0
4z90G-1urhA:
0.0
4z90H-1urhA:
0.0
4z90I-1urhA:
0.0
4z90J-1urhA:
0.0		 4z90F-1urhA:
21.97
4z90G-1urhA:
21.97
4z90H-1urhA:
21.97
4z90I-1urhA:
21.97
4z90J-1urhA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		3 / 3 ILE A  46
PRO A  47
ILE A  22
 None
 0.43A 5hw8F-1urhA:
undetectable		 5hw8F-1urhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		3 / 3 HIS A  14
GLU A  13
TRP A  10
 None
 0.63A 5odiD-1urhA:
undetectable		 5odiD-1urhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		3 / 3 HIS A  14
GLU A  13
TRP A  10
 None
 0.64A 5odqD-1urhA:
undetectable		 5odqD-1urhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		3 / 3 HIS A  14
GLU A  13
TRP A  10
 None
 0.57A 5odrD-1urhA:
undetectable		 5odrD-1urhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 122
GLY A  95
ILE A  46
VAL A  91
GLY A 121
 None
 0.86A 5zhmB-1urhA:
undetectable		 5zhmB-1urhA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1urh 3-MERCAPTOPYRUVATE
SULFURTRANSFERASE
(Escherichia
coli) 		4 / 8 ARG A 208
VAL A  91
ARG A  35
GLN A  32
 None
 1.09A 6fbvD-1urhA:
undetectable		 6fbvD-1urhA:
12.17