SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1urj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 TYR A 661
LEU A  18
SER A  91
VAL A 169
LEU A 236
 None
 1.34A 1db1A-1urjA:
0.0		 1db1A-1urjA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 4 ILE A 985
LEU A 981
VAL A 535
ILE A 533
 None
 0.94A 1fm6D-1urjA:
0.0		 1fm6D-1urjA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 ARG A 772
SER A 655
SER A 725
ASN A 720
 None
 1.21A 1hwiB-1urjA:
undetectable		 1hwiB-1urjA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 ARG A 772
SER A 655
SER A 725
ASN A 720
 None
 1.23A 1hwkC-1urjA:
undetectable		 1hwkC-1urjA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 ARG A 772
SER A 655
SER A 725
ASN A 720
 None
 1.22A 1hwkD-1urjA:
undetectable		 1hwkD-1urjA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 LEU A1016
LEU A1015
PHE A 963
ALA A1027
 None
None
HG  A2132 (-2.6A)
None
 0.87A 1j8uA-1urjA:
undetectable		 1j8uA-1urjA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 11 LEU A 515
PHE A 446
LEU A 466
LEU A 112
LEU A 469
 None
 1.27A 1mx1B-1urjA:
1.4		 1mx1B-1urjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.91A 1ra8A-1urjA:
undetectable		 1ra8A-1urjA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.95A 1rd7A-1urjA:
undetectable		 1rd7A-1urjA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.92A 1rd7B-1urjA:
undetectable		 1rd7B-1urjA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 LEU A 981
ALA A 532
ILE A 533
GLY A1001
 None
 0.83A 1sv9A-1urjA:
undetectable		 1sv9A-1urjA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 THR A 226
GLU A 753
HIS A 177
 None
 0.89A 1xwfA-1urjA:
undetectable		 1xwfA-1urjA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 THR A 226
GLU A 753
HIS A 177
 None
 0.91A 1xwfB-1urjA:
0.0		 1xwfB-1urjA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 THR A 226
GLU A 753
HIS A 177
 None
 0.90A 1xwfC-1urjA:
0.0		 1xwfC-1urjA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 LEU A 672
GLY A 673
LEU A 668
PRO A 247
 None
 0.92A 1ya4A-1urjA:
undetectable		 1ya4A-1urjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 10 ALA A 319
ALA A 323
LEU A 678
LEU A 252
ALA A 251
 None
 1.19A 2bxeA-1urjA:
0.0		 2bxeA-1urjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.95A 2d0kB-1urjA:
undetectable		 2d0kB-1urjA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 6 ARG A 147
GLU A 142
PRO A 152
ALA A 155
 None
 1.47A 2ejfB-1urjA:
0.0		 2ejfB-1urjA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 ARG A 147
GLU A 142
PRO A 152
ALA A 155
 None
 1.37A 2ejgA-1urjA:
0.0		 2ejgA-1urjA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 TYR A 158
ALA A  35
SER A  38
ALA A  49
PRO A  27
 None
 1.25A 2igtC-1urjA:
undetectable		 2igtC-1urjA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 CYH A 499
CYH A 510
HIS A 512
 ZN  A2131 (-2.3A)
ZN  A2131 (-2.4A)
ZN  A2131 (-2.8A)
 0.82A 2iwkA-1urjA:
0.0		 2iwkA-1urjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 CYH A 499
CYH A 510
HIS A 512
 ZN  A2131 (-2.3A)
ZN  A2131 (-2.4A)
ZN  A2131 (-2.8A)
 0.83A 2iwkB-1urjA:
0.0		 2iwkB-1urjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 4 LEU A 847
THR A 845
ILE A 826
HIS A 823
 None
 1.03A 2jfaB-1urjA:
undetectable		 2jfaB-1urjA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 GLY A 537
GLY A 673
LEU A 656
LEU A 771
VAL A 773
 None
 0.80A 2yqzB-1urjA:
undetectable		 2yqzB-1urjA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 ALA A 265
ALA A 264
ALA A 268
CYH A 170
 None
 0.89A 3a2qA-1urjA:
undetectable		 3a2qA-1urjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 GLY A 412
THR A 413
PHE A 287
ALA A 416
 None
 0.72A 3aruA-1urjA:
undetectable		 3aruA-1urjA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ALA A 382
GLY A 534
SER A 378
SER A 676
LEU A 671
 None
 1.36A 3bxoA-1urjA:
undetectable		 3bxoA-1urjA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 6 LEU A 115
ALA A 109
SER A  41
THR A 107
 None
 1.04A 3cfqA-1urjA:
undetectable		 3cfqA-1urjA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 5 ALA A 263
ALA A 322
TYR A 681
MET A 716
 None
 1.15A 3d91A-1urjA:
undetectable		 3d91A-1urjA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 5 ALA A 264
ALA A 322
TYR A 681
MET A 716
 None
 1.07A 3d91A-1urjA:
undetectable		 3d91A-1urjA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 CYH A 499
CYH A 510
HIS A 512
 ZN  A2131 (-2.3A)
ZN  A2131 (-2.4A)
ZN  A2131 (-2.8A)
 0.67A 3dtuB-1urjA:
0.0		 3dtuB-1urjA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 CYH A 499
CYH A 510
HIS A 512
 ZN  A2131 (-2.3A)
ZN  A2131 (-2.4A)
ZN  A2131 (-2.8A)
 0.64A 3dtuD-1urjA:
0.0		 3dtuD-1urjA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 MET A 516
CYH A 502
PRO A 498
 None
ZN  A2131 (-2.3A)
None
 1.05A 3h52C-1urjA:
undetectable		 3h52C-1urjA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 9 MET A 465
LEU A 668
ARG A 674
ARG A 675
GLY A 456
 None
 1.48A 3hcnB-1urjA:
0.0		 3hcnB-1urjA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 156
LEU A  55
ILE A  31
ALA A  35
SER A  38
 None
 1.09A 3n8zB-1urjA:
undetectable		 3n8zB-1urjA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ALA A 243
SER A  92
TYR A  95
VAL A  46
ALA A  39
 None
 1.30A 3qxvE-1urjA:
undetectable		 3qxvE-1urjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 5 LYS A 869
ILE A 868
PHE A 827
LEU A 847
 None
 1.48A 3tf1A-1urjA:
0.0		 3tf1A-1urjA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 985
LEU A 771
GLY A 534
ASN A 380
GLY A 531
 None
 1.03A 3uq6A-1urjA:
undetectable		 3uq6A-1urjA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 985
LEU A 771
GLY A 534
ASN A 380
GLY A 531
 None
 1.01A 3vaqA-1urjA:
undetectable		 3vaqA-1urjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 985
LEU A 771
GLY A 534
ASN A 380
GLY A 531
 None
 0.97A 3vaqB-1urjA:
undetectable		 3vaqB-1urjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 985
LEU A 771
GLY A 534
ASN A 380
GLY A 531
 None
 1.05A 3vasA-1urjA:
undetectable		 3vasA-1urjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 985
LEU A 771
GLY A 534
ASN A 380
GLY A 531
 None
 1.00A 3vasB-1urjA:
undetectable		 3vasB-1urjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.84A 4ej1A-1urjA:
undetectable		 4ej1A-1urjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.84A 4fhbA-1urjA:
undetectable		 4fhbA-1urjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		6 / 11 PHE A 822
ALA A 612
LEU A 613
THR A 615
VAL A 617
LEU A 818
 None
 1.34A 4g1bB-1urjA:
undetectable		 4g1bB-1urjA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.99A 4i13A-1urjA:
undetectable		 4i13A-1urjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 LEU A 112
ALA A 460
LEU A 462
SER A 455
 None
 1.15A 4iklA-1urjA:
undetectable
4iklB-1urjA:
undetectable		 4iklA-1urjA:
7.18
4iklB-1urjA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.90A 4kjjA-1urjA:
undetectable		 4kjjA-1urjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.83A 4kjkA-1urjA:
undetectable		 4kjkA-1urjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.91A 4kjlA-1urjA:
undetectable		 4kjlA-1urjA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.88A 4p3qA-1urjA:
undetectable		 4p3qA-1urjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.88A 4p3rA-1urjA:
undetectable		 4p3rA-1urjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.88A 4pssA-1urjA:
undetectable		 4pssA-1urjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.89A 4pthA-1urjA:
undetectable		 4pthA-1urjA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ALA A1125
ALA A1071
ILE A1057
LEU A1097
MET A1101
 None
 1.18A 4r3aA-1urjA:
undetectable		 4r3aA-1urjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 SER A 331
ALA A 264
LEU A 267
PHE A 693
 None
 0.97A 4rkuA-1urjA:
0.1
4rkuJ-1urjA:
0.0		 4rkuA-1urjA:
21.92
4rkuJ-1urjA:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.88A 4x5gB-1urjA:
undetectable		 4x5gB-1urjA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.86A 4x5iA-1urjA:
undetectable		 4x5iA-1urjA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 VAL A  65
PHE A  61
ARG A 193
 None
 0.93A 4xr4B-1urjA:
undetectable		 4xr4B-1urjA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 5 LEU A 778
ALA A 897
ASN A 898
ILE A 881
 None
 1.18A 4y03B-1urjA:
undetectable		 4y03B-1urjA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 PHE A  97
GLY A 141
THR A 139
LEU A 176
 None
 0.94A 4zdzA-1urjA:
undetectable		 4zdzA-1urjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 7 PHE A  97
GLY A 141
THR A 139
LEU A 176
 None
 0.87A 4ze3A-1urjA:
undetectable		 4ze3A-1urjA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 11 LEU A 724
LEU A 658
LEU A 684
ILE A 985
LEU A 409
 None
 1.04A 4zowA-1urjA:
undetectable		 4zowA-1urjA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.86A 5eajA-1urjA:
undetectable		 5eajA-1urjA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 PHE A  97
GLY A 141
THR A 139
LEU A 176
 None
 0.91A 5esjA-1urjA:
undetectable		 5esjA-1urjA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 LEU A  37
LEU A  55
ARG A 101
 None
 0.55A 5hnzB-1urjA:
undetectable		 5hnzB-1urjA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 LEU A 469
LEU A 451
ARG A  40
 None
 0.62A 5hnzB-1urjA:
undetectable		 5hnzB-1urjA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 VAL A 410
LEU A 711
MET A 318
 None
 0.69A 5ikrA-1urjA:
undetectable		 5ikrA-1urjA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		3 / 3 THR A 140
PRO A 130
ARG A 131
 None
 0.82A 5nd7B-1urjA:
undetectable		 5nd7B-1urjA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 10 LEU A 385
HIS A 384
ILE A 533
GLY A 534
ALA A 679
 None
 1.01A 5o96C-1urjA:
undetectable
5o96D-1urjA:
undetectable		 5o96C-1urjA:
12.35
5o96D-1urjA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ALA A 368
TRP A 933
PRO A 925
ALA A 369
GLY A 370
 None
 1.35A 5tzoA-1urjA:
undetectable		 5tzoA-1urjA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ALA A 368
TRP A 933
PRO A 925
ALA A 369
GLY A 370
 None
 1.35A 5tzoC-1urjA:
undetectable		 5tzoC-1urjA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 GLY A 448
LEU A 115
VAL A 511
HIS A 512
LEU A 501
 None
None
None
ZN  A2131 (-2.8A)
None
 1.24A 5ubbA-1urjA:
undetectable		 5ubbA-1urjA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.88A 5ujxA-1urjA:
undetectable		 5ujxA-1urjA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.88A 5z6jA-1urjA:
undetectable		 5z6jA-1urjA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.85A 5z6kA-1urjA:
undetectable		 5z6kA-1urjA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 10 SER A 331
GLY A 164
ALA A 264
LEU A 267
PHE A 693
 None
 1.01A 5zjiA-1urjA:
undetectable
5zjiJ-1urjA:
undetectable		 5zjiA-1urjA:
5.89
5zjiJ-1urjA:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 317
VAL A 388
LEU A 409
ALA A 685
LEU A 686
 None
 1.16A 6ajiA-1urjA:
undetectable		 6ajiA-1urjA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 PHE A 963
ALA A 919
PHE A 467
ALA A  47
ALA A  49
 HG  A2132 (-2.6A)
None
None
None
None
 1.35A 6aycA-1urjA:
undetectable		 6aycA-1urjA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 4 ALA A  39
ALA A  47
ALA A 460
ALA A 463
 None
 0.83A 6gtqA-1urjA:
0.3
6gtqB-1urjA:
0.2		 6gtqA-1urjA:
10.11
6gtqB-1urjA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 4 ALA A 460
ALA A 463
ALA A  39
ALA A  47
 None
 0.82A 6gtqA-1urjA:
0.3
6gtqB-1urjA:
0.2		 6gtqA-1urjA:
10.11
6gtqB-1urjA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 10 LEU A 365
VAL A 361
ILE A 342
THR A  56
ALA A  49
 None
 1.00A 6h1lA-1urjA:
undetectable		 6h1lA-1urjA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		4 / 8 PHE A 202
PHE A 175
VAL A  68
SER A  71
 None
 1.24A 6huoC-1urjA:
undetectable
6huoD-1urjA:
undetectable		 6huoC-1urjA:
6.34
6huoD-1urjA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 10 LEU A 981
LEU A 672
GLY A 673
ASN A 677
MET A 375
 None
 1.41A 6r2eC-1urjA:
0.0		 6r2eC-1urjA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1urj MAJOR DNA-BINDING
PROTEIN
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 607
THR A 864
ILE A 868
LEU A 819
ILE A 826
 None
 0.93A 7dfrA-1urjA:
undetectable		 7dfrA-1urjA:
8.52