SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1us2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 HIS A 363
MET A 346
MET A 300
 None
 1.19A 2vj1A-1us2A:
undetectable		 2vj1A-1us2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 12 LEU A 166
GLY A 219
TRP A 103
PHE A 159
VAL A  97
 None
 1.24A 2w8yA-1us2A:
undetectable		 2w8yA-1us2A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		4 / 5 VAL A 533
TYR A 530
VAL A 500
ASP A 499
 None
 1.32A 2x45A-1us2A:
undetectable		 2x45A-1us2A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		4 / 5 VAL A 533
TYR A 530
VAL A 500
ASP A 499
 None
 1.29A 2x45C-1us2A:
undetectable		 2x45C-1us2A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 VAL A 500
TRP A 552
TRP A 560
 None
XYP  A1609 ( 4.1A)
XYP  A1609 ( 4.0A)
 1.33A 2xdcA-1us2A:
undetectable
2xdcB-1us2A:
undetectable		 2xdcA-1us2A:
3.14
2xdcB-1us2A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 TRP A 560
VAL A 500
TRP A 552
 XYP  A1609 ( 4.0A)
None
XYP  A1609 ( 4.1A)
 1.34A 2xdcA-1us2A:
undetectable
2xdcB-1us2A:
undetectable		 2xdcA-1us2A:
3.14
2xdcB-1us2A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 VAL A 500
TRP A 552
TRP A 560
 None
XYP  A1609 ( 4.1A)
XYP  A1609 ( 4.0A)
 1.34A 2y5mA-1us2A:
undetectable
2y5mB-1us2A:
undetectable		 2y5mA-1us2A:
3.14
2y5mB-1us2A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		4 / 4 VAL A 551
TRP A 560
VAL A 500
TRP A 552
 None
XYP  A1609 ( 4.0A)
None
XYP  A1609 ( 4.1A)
 1.36A 2y5mA-1us2A:
undetectable
2y5mB-1us2A:
undetectable		 2y5mA-1us2A:
3.14
2y5mB-1us2A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 VAL A 500
TRP A 552
TRP A 560
 None
XYP  A1609 ( 4.1A)
XYP  A1609 ( 4.0A)
 1.34A 2y6nA-1us2A:
undetectable
2y6nB-1us2A:
undetectable		 2y6nA-1us2A:
3.14
2y6nB-1us2A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 TRP A 560
VAL A 500
TRP A 552
 XYP  A1609 ( 4.0A)
None
XYP  A1609 ( 4.1A)
 1.34A 2y6nA-1us2A:
undetectable
2y6nB-1us2A:
undetectable		 2y6nA-1us2A:
3.14
2y6nB-1us2A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 10 GLY A 219
GLN A 217
ILE A 232
VAL A 235
VAL A  97
 None
XYP  A1611 (-3.2A)
None
None
None
 1.31A 3fhjA-1us2A:
undetectable		 3fhjA-1us2A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 10 GLY A 219
GLN A 217
ILE A 232
VAL A 235
VAL A  97
 None
XYP  A1611 (-3.2A)
None
None
None
 1.31A 3fhjB-1us2A:
undetectable		 3fhjB-1us2A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 10 GLY A 219
GLN A 217
ILE A 232
VAL A 235
VAL A  97
 None
XYP  A1611 (-3.2A)
None
None
None
 1.31A 3fhjE-1us2A:
undetectable		 3fhjE-1us2A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 9 GLY A 219
GLN A 217
ILE A 232
VAL A 235
VAL A  97
 None
XYP  A1611 (-3.2A)
None
None
None
 1.32A 3fi0H-1us2A:
undetectable		 3fi0H-1us2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 9 GLY A 219
GLN A 217
ILE A 232
VAL A 235
VAL A  97
 None
XYP  A1611 (-3.2A)
None
None
None
 1.37A 3fi0N-1us2A:
undetectable		 3fi0N-1us2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 12 VAL A 319
TYR A 371
GLY A 295
ALA A 294
LEU A 292
 None
 0.89A 3hs6A-1us2A:
undetectable		 3hs6A-1us2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 ASN A 440
ASN A 435
GLU A 437
 None
 0.92A 3kpdC-1us2A:
undetectable		 3kpdC-1us2A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 10 ILE A 476
ALA A 536
LEU A 498
THR A 293
THR A 540
 None
 1.22A 3prsA-1us2A:
undetectable		 3prsA-1us2A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 VAL A 500
TRP A 552
TRP A 560
 None
XYP  A1609 ( 4.1A)
XYP  A1609 ( 4.0A)
 1.33A 3zq8A-1us2A:
undetectable
3zq8B-1us2A:
undetectable		 3zq8A-1us2A:
3.14
3zq8B-1us2A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 TRP A 560
VAL A 551
TRP A 552
 XYP  A1609 ( 4.0A)
None
XYP  A1609 ( 4.1A)
 0.95A 3zq8C-1us2A:
undetectable
3zq8D-1us2A:
undetectable		 3zq8C-1us2A:
3.14
3zq8D-1us2A:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 12 VAL A 486
GLN A 466
THR A 496
ILE A 436
PHE A 465
 None
XYP  A1609 (-2.7A)
None
None
None
 1.45A 4c49D-1us2A:
undetectable		 4c49D-1us2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 12 PHE A 465
GLY A 490
LEU A 489
GLN A 545
VAL A 450
 None
 1.10A 4wnwB-1us2A:
undetectable		 4wnwB-1us2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		6 / 12 GLY A 105
PHE A 125
VAL A 135
LEU A 166
ILE A 220
GLY A 131
 None
 1.07A 5hieA-1us2A:
undetectable		 5hieA-1us2A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 ALA A 164
ASN A 165
LEU A 166
 None
 0.45A 5i1pD-1us2A:
undetectable		 5i1pD-1us2A:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 VAL A 427
SER A 379
TRP A 380
 None
 1.03A 5jwaA-1us2A:
undetectable		 5jwaA-1us2A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		4 / 5 PHE A 289
SER A 550
ASN A 267
ASP A 269
 None
 1.50A 5kpcA-1us2A:
0.4		 5kpcA-1us2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 LYS A 287
HIS A 288
HIS A 250
 None
 1.29A 5oexA-1us2A:
undetectable		 5oexA-1us2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 LYS A 287
HIS A 288
HIS A 250
 None
 1.27A 5oexB-1us2A:
undetectable		 5oexB-1us2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 LYS A 287
HIS A 288
HIS A 250
 None
 1.29A 5oexC-1us2A:
undetectable		 5oexC-1us2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		3 / 3 LYS A 287
HIS A 288
HIS A 250
 None
 1.30A 5oexD-1us2A:
undetectable		 5oexD-1us2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 1us2 ENDO-BETA-1,4-XYLANA
SE
(Cellvibrio
japonicus) 		5 / 7 ASP A 361
THR A 362
LEU A 360
THR A 419
VAL A 411
 None
 1.48A 5ov9A-1us2A:
undetectable		 5ov9A-1us2A:
22.07