SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1us4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 9 ASN A 146
GLU A 144
ILE A  91
ALA A  85
ILE A  81
None
1.28A 1aj6A-1us4A:
undetectable
1aj6A-1us4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 5 ARG A 118
ALA A 117
ASP A 120
GLY A 122
None
0.98A 1e7bA-1us4A:
undetectable
1e7bA-1us4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 5 ARG A 118
ALA A 117
ASP A 120
GLY A 122
None
1.11A 1e7cA-1us4A:
undetectable
1e7cA-1us4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 7 LEU A 256
THR A 260
GLY A 302
LEU A 105
None
0.92A 1gtiA-1us4A:
undetectable
1gtiA-1us4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 7 LEU A 256
THR A 260
GLY A 302
LEU A 105
None
0.70A 1gtiB-1us4A:
undetectable
1gtiB-1us4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 7 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.02A 1rxcF-1us4A:
undetectable
1rxcF-1us4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 7 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.06A 1rxcL-1us4A:
undetectable
1rxcL-1us4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
3 / 3 ARG A 305
TYR A 262
LYS A 266
None
0.78A 1uujB-1us4A:
undetectable
1uujB-1us4A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 ARG A 118
VAL A 134
LEU A 129
ALA A 121
None
1.07A 2e1qA-1us4A:
undetectable
2e1qA-1us4A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 ARG A 118
VAL A 134
LEU A 129
ALA A 121
None
1.05A 2e1qC-1us4A:
undetectable
2e1qC-1us4A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 7 ALA A  36
THR A  37
ALA A  40
ARG A  51
None
0.59A 2ql8A-1us4A:
2.0
2ql8B-1us4A:
2.0
2ql8A-1us4A:
18.54
2ql8B-1us4A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 8 ARG A 118
VAL A 134
LEU A 129
ALA A 121
None
1.01A 3ax7A-1us4A:
undetectable
3ax7A-1us4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 12 ILE A  39
LEU A 108
ALA A 291
PHE A 264
PHE A 275
None
1.01A 3b2rA-1us4A:
undetectable
3b2rA-1us4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 8 GLN A 145
ILE A 214
VAL A 244
VAL A 113
None
0.67A 3fi0Q-1us4A:
undetectable
3fi0Q-1us4A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 10 ASN A  53
VAL A 268
ALA A  54
ILE A  23
LEU A 250
None
1.15A 3fl9F-1us4A:
undetectable
3fl9F-1us4A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 12 GLN A  78
GLY A 140
GLY A 142
ALA A  62
ASN A  65
GLU  A1313 (-3.7A)
None
GLU  A1313 (-3.5A)
None
None
1.07A 3kkzA-1us4A:
undetectable
3kkzA-1us4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 12 GLN A  78
GLY A 140
GLY A 142
ALA A  62
ASN A  65
GLU  A1313 (-3.7A)
None
GLU  A1313 (-3.5A)
None
None
1.07A 3kkzB-1us4A:
undetectable
3kkzB-1us4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.04A 3kvvA-1us4A:
undetectable
3kvvA-1us4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.08A 3kvvB-1us4A:
undetectable
3kvvB-1us4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.09A 3kvvC-1us4A:
undetectable
3kvvC-1us4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.09A 3kvvD-1us4A:
undetectable
3kvvD-1us4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.06A 3kvvE-1us4A:
undetectable
3kvvE-1us4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.03A 3kvvF-1us4A:
undetectable
3kvvF-1us4A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 12 GLN A  78
GLY A 140
GLY A 142
ALA A  62
ASN A  65
GLU  A1313 (-3.7A)
None
GLU  A1313 (-3.5A)
None
None
1.15A 3sxjA-1us4A:
undetectable
3sxjA-1us4A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 12 GLN A  78
GLY A 140
GLY A 142
ALA A  62
ASN A  65
GLU  A1313 (-3.7A)
None
GLU  A1313 (-3.5A)
None
None
1.15A 3sxjB-1us4A:
undetectable
3sxjB-1us4A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 PHE A 285
ALA A 245
THR A 243
LEU A 190
None
0.95A 3t3zA-1us4A:
undetectable
3t3zA-1us4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 PHE A 285
ALA A 245
THR A 243
LEU A 190
None
0.93A 3t3zB-1us4A:
undetectable
3t3zB-1us4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 5 PHE A 285
ALA A 245
THR A 243
LEU A 190
None
0.94A 3t3zC-1us4A:
undetectable
3t3zC-1us4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 PHE A 285
ALA A 245
THR A 243
LEU A 190
None
0.96A 3t3zD-1us4A:
undetectable
3t3zD-1us4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 12 GLN A  78
GLY A 140
GLY A 142
ALA A  62
ASN A  65
GLU  A1313 (-3.7A)
None
GLU  A1313 (-3.5A)
None
None
1.12A 3t7sB-1us4A:
undetectable
3t7sB-1us4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 12 GLN A  78
GLY A 140
GLY A 142
ALA A  62
ASN A  65
GLU  A1313 (-3.7A)
None
GLU  A1313 (-3.5A)
None
None
1.12A 3t7sD-1us4A:
undetectable
3t7sD-1us4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 7 ARG A 118
VAL A 134
LEU A 129
ALA A 121
None
1.02A 3uniA-1us4A:
undetectable
3uniA-1us4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 7 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.06A 4e1vB-1us4A:
undetectable
4e1vB-1us4A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 6 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
1.02A 4e1vF-1us4A:
undetectable
4e1vF-1us4A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 8 GLY A 172
GLN A 174
ILE A 165
VAL A 167
None
0.99A 4e1vG-1us4A:
undetectable
4e1vG-1us4A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 8 ILE A  23
LEU A  76
ILE A 278
GLY A  30
None
None
None
GLU  A1313 ( 4.0A)
0.78A 4hb8A-1us4A:
undetectable
4hb8A-1us4A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 4 TYR A 154
THR A 243
VAL A 115
ILE A 214
None
1.49A 4jx1F-1us4A:
0.0
4jx1F-1us4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
3 / 3 SER A  60
TYR A  32
ASP A  80
GLU  A1313 (-2.6A)
GLU  A1313 (-3.7A)
None
0.73A 4rp8C-1us4A:
undetectable
4rp8C-1us4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 4 TYR A 109
GLY A  26
SER A  25
LEU A  76
None
GLU  A1313 ( 3.8A)
None
None
1.37A 5bphC-1us4A:
2.9
5bphC-1us4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 4 ILE A 251
GLY A  24
ILE A  67
LEU A  76
None
0.87A 5dzkl-1us4A:
undetectable
5dzkz-1us4A:
undetectable
5dzkl-1us4A:
23.77
5dzkz-1us4A:
0.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
4 / 4 LEU A 282
ILE A 278
PRO A  34
LEU A  76
None
1.19A 5eb3A-1us4A:
undetectable
5eb3A-1us4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
5 / 12 VAL A  35
VAL A  31
ILE A  64
ALA A  66
ALA A  75
None
GLU  A1313 (-3.8A)
None
None
None
1.19A 5x7fA-1us4A:
undetectable
5x7fA-1us4A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus)
3 / 3 LEU A 282
GLY A 287
PHE A 306
None
0.64A 6exiC-1us4A:
undetectable
6exiC-1us4A:
13.38