SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1us7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens) 		3 / 3 LEU B 305
LEU B 301
SER B 300
 None
 0.68A 1tlmA-1us7B:
undetectable		 1tlmA-1us7B:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens) 		3 / 3 LEU B 301
PRO B 302
LEU B 305
 None
 0.58A 2po5B-1us7B:
undetectable		 2po5B-1us7B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens) 		3 / 3 LEU B 301
PRO B 302
LEU B 305
 None
 0.48A 2po7B-1us7B:
undetectable		 2po7B-1us7B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens) 		3 / 3 LEU B 301
PRO B 302
LEU B 305
 None
 0.31A 2qd5B-1us7B:
undetectable		 2qd5B-1us7B:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens) 		3 / 3 LEU B 301
PRO B 302
LEU B 305
 None
 0.45A 3hcrA-1us7B:
undetectable		 3hcrA-1us7B:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens) 		3 / 3 LEU B 301
PRO B 302
LEU B 305
 None
 0.42A 3w1wB-1us7B:
undetectable		 3w1wB-1us7B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens) 		4 / 5 THR B 213
ILE B 214
GLU B 255
PHE B 237
 None
 1.48A 4acbC-1us7B:
undetectable		 4acbC-1us7B:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens) 		3 / 3 GLN B 212
HIS B 211
ARG B 166
 None
 1.30A 4qyqA-1us7B:
undetectable		 4qyqA-1us7B:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1us7 HSP90 CO-CHAPERONE
CDC37
(Homo
sapiens) 		4 / 7 ILE B 159
PHE B 237
CYH B 194
PHE B 218
 None
 1.10A 5hieA-1us7B:
undetectable		 5hieA-1us7B:
23.44