SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1us8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 4 GLU B 815
MET A   1
LEU B 818
SER B 817
 None
 1.39A 1ee2B-1us8B:
0.9		 1ee2B-1us8B:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 12 LEU B 810
PHE B 759
TYR B 843
ALA B 752
GLY B 801
 None
 1.05A 1fe2A-1us8B:
undetectable		 1fe2A-1us8B:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 12 LEU B 810
PHE B 759
TYR B 843
ALA B 752
GLY B 801
 None
 1.02A 1igxA-1us8B:
undetectable		 1igxA-1us8B:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 11 LEU B 871
GLY A  33
SER A  38
VAL B 853
HIS A  14
 None
 1.14A 1mx1A-1us8B:
undetectable		 1mx1A-1us8B:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		5 / 11 ALA B 752
MET B 808
GLY B 801
ILE A 146
VAL B 776
 None
 1.15A 2uxpB-1us8B:
undetectable		 2uxpB-1us8B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 7 VAL B 769
ILE B 748
ALA B 752
VAL B 767
 None
 0.79A 2xrzB-1us8B:
undetectable		 2xrzB-1us8B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 6 HIS A  14
SER A  37
LEU A   3
ILE A  28
 None
 0.85A 3kk6A-1us8A:
undetectable		 3kk6A-1us8A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 12 VAL B 767
VAL B 780
GLY B 749
ALA B 771
ILE B 748
 None
 1.04A 3ku1H-1us8B:
undetectable		 3ku1H-1us8B:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 7 ILE A 146
LEU A 147
LEU B 792
SER B 765
 None
 0.95A 3r9vA-1us8A:
undetectable
3r9vB-1us8A:
undetectable		 3r9vA-1us8A:
22.27
3r9vB-1us8A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 10 ILE A  43
LEU B 818
PHE A  21
ASN A  26
LYS A  77
 None
 1.40A 4eb4D-1us8A:
0.0		 4eb4D-1us8A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 PHE A  21
VAL A  19
ILE B 867
ALA B 863
 None
 0.99A 4eyzA-1us8A:
undetectable		 4eyzA-1us8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		4 / 8 PHE A  21
VAL A  19
ILE B 867
ALA B 863
 None
 0.99A 4eyzB-1us8A:
undetectable		 4eyzB-1us8A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 8 GLY B 801
THR B 825
LEU B 821
ARG B 805
 None
 0.93A 4m5mA-1us8B:
undetectable		 4m5mA-1us8B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 146
ILE B 839
ALA B 799
LEU B 800
LEU A 147
 None
 0.96A 4o1zA-1us8A:
undetectable		 4o1zA-1us8A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 10 LEU B 818
LEU A 133
LEU A  44
ILE A  43
LEU A  47
 None
 1.08A 4odoA-1us8B:
undetectable		 4odoA-1us8B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 10 LEU B 818
LEU A 133
LEU A  44
ILE A  43
LEU A  47
 None
 1.08A 4odoB-1us8B:
undetectable		 4odoB-1us8B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 11 LEU B 818
LEU A 133
LEU A  44
ILE A  43
LEU A  47
 None
 1.05A 4odrA-1us8B:
undetectable
4odrB-1us8B:
undetectable		 4odrA-1us8B:
19.50
4odrB-1us8B:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 7 ASN A  26
GLU A  20
GLU A   4
GLU A  23
 None
 1.19A 4r87I-1us8A:
undetectable		 4r87I-1us8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 6 ILE A  84
LEU A  73
ARG A 102
THR A  80
 None
 0.90A 5b1aN-1us8A:
undetectable
5b1aW-1us8A:
undetectable		 5b1aN-1us8A:
14.25
5b1aW-1us8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 143
GLY A 141
PHE A 132
ASP B 822
 None
 1.13A 5hieA-1us8A:
undetectable		 5hieA-1us8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		5 / 12 VAL B 769
ALA B 752
VAL B 767
LEU B 789
LEU B 812
 None
 1.07A 5hv1A-1us8B:
undetectable		 5hv1A-1us8B:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 7 ILE B 798
LEU B 836
LEU B 859
PRO B 824
 None
 0.91A 5u4sA-1us8B:
undetectable		 5u4sA-1us8B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE
(Pyrococcus
furiosus) 		4 / 6 ILE A  84
LEU A  73
ARG A 102
THR A  80
 None
 0.96A 6nmfN-1us8A:
undetectable
6nmfW-1us8A:
undetectable		 6nmfN-1us8A:
14.25
6nmfW-1us8A:
22.48