SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1usc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 7 GLY A 113
ALA A 117
HIS A 101
SER A  71
 None
 0.89A 1c9sT-1uscA:
undetectable
1c9sU-1uscA:
undetectable		 1c9sT-1uscA:
21.94
1c9sU-1uscA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 7 GLY A 113
ALA A 117
HIS A 101
SER A  71
 None
 0.89A 1gtfL-1uscA:
undetectable
1gtfM-1uscA:
undetectable		 1gtfL-1uscA:
21.94
1gtfM-1uscA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 4 SER A  71
VAL A  52
PHE A  34
VAL A  32
 None
 1.35A 1o86A-1uscA:
undetectable		 1o86A-1uscA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		3 / 3 VAL A  38
VAL A  52
TRP A  39
 FMN  A1179 (-4.0A)
None
ACT  A1180 ( 3.3A)
 0.96A 1w5uA-1uscA:
undetectable
1w5uB-1uscA:
undetectable		 1w5uA-1uscA:
8.39
1w5uB-1uscA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		5 / 12 PHE A  70
GLY A  51
GLY A  62
LEU A  64
LEU A  63
 None
 1.06A 2hw2A-1uscA:
undetectable		 2hw2A-1uscA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		3 / 3 VAL A  52
TRP A  39
VAL A  38
 None
ACT  A1180 ( 3.3A)
FMN  A1179 (-4.0A)
 0.98A 2izqC-1uscA:
undetectable
2izqD-1uscA:
undetectable		 2izqC-1uscA:
8.39
2izqD-1uscA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 6 TYR A  16
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 1.26A 2r6vA-1uscA:
23.8		 2r6vA-1uscA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 6 TYR A  17
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 0.53A 2r6vA-1uscA:
23.8		 2r6vA-1uscA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 7 TYR A  16
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 1.26A 3zodA-1uscA:
24.1		 3zodA-1uscA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 7 TYR A  17
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 0.51A 3zodA-1uscA:
24.1		 3zodA-1uscA:
28.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOF_A_HQEA200_1
(FLAVOREDOXIN)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 5 TYR A  16
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 1.44A 3zofA-1uscA:
33.3		 3zofA-1uscA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOF_A_HQEA200_1
(FLAVOREDOXIN)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		5 / 5 TYR A  17
VAL A  38
TRP A  39
ARG A  58
HIS A 131
 None
FMN  A1179 (-4.0A)
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 0.16A 3zofA-1uscA:
33.3		 3zofA-1uscA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOF_B_HQEB200_1
(FLAVOREDOXIN)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 5 TYR A  14
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 1.26A 3zofB-1uscA:
33.1		 3zofB-1uscA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOF_B_HQEB200_1
(FLAVOREDOXIN)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 5 TYR A  16
TRP A  39
ARG A  58
HIS A 131
 None
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 1.42A 3zofB-1uscA:
33.1		 3zofB-1uscA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOF_B_HQEB200_1
(FLAVOREDOXIN)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		5 / 5 TYR A  17
VAL A  38
TRP A  39
ARG A  58
HIS A 131
 None
FMN  A1179 (-4.0A)
ACT  A1180 ( 3.3A)
FMN  A1179 ( 3.8A)
ACT  A1180 ( 4.0A)
 0.12A 3zofB-1uscA:
33.1		 3zofB-1uscA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT
(Thermus
thermophilus) 		4 / 4 ASP A 130
ALA A  37
SER A  53
PHE A  13
 None
FMN  A1179 (-3.5A)
None
None
 1.36A 6cm4A-1uscA:
undetectable		 6cm4A-1uscA:
15.42