SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1uso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA8_0
(MINI-GRAMICIDIN A)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 5 VAL A  51
TRP A   3
ALA A  28
TRP A  55
 None
 1.49A 1kqeA-1usoA:
undetectable
1kqeE-1usoA:
undetectable		 1kqeA-1usoA:
9.38
1kqeE-1usoA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.03A 1v54A-1usoA:
undetectable
1v54J-1usoA:
undetectable		 1v54A-1usoA:
8.56
1v54J-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.04A 2dyrA-1usoA:
undetectable
2dyrJ-1usoA:
undetectable		 2dyrA-1usoA:
8.56
2dyrJ-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.04A 2dysA-1usoA:
undetectable
2dysJ-1usoA:
undetectable		 2dysA-1usoA:
8.56
2dysJ-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.03A 2eijA-1usoA:
undetectable
2eijJ-1usoA:
undetectable		 2eijA-1usoA:
8.56
2eijJ-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.03A 2eilA-1usoA:
undetectable
2eilJ-1usoA:
undetectable		 2eilA-1usoA:
8.56
2eilJ-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.10A 2zxwA-1usoA:
undetectable
2zxwJ-1usoA:
undetectable		 2zxwA-1usoA:
8.56
2zxwJ-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.05A 3abmA-1usoA:
undetectable
3abmJ-1usoA:
undetectable		 3abmA-1usoA:
8.56
3abmJ-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.03A 3asnA-1usoA:
undetectable
3asnJ-1usoA:
undetectable		 3asnA-1usoA:
8.56
3asnJ-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.05A 3asoA-1usoA:
undetectable
3asoJ-1usoA:
undetectable		 3asoA-1usoA:
8.56
3asoJ-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 5 ASP A  26
VAL A  46
PHE A  21
GLY A  49
 None
 1.02A 4xp6A-1usoA:
undetectable		 4xp6A-1usoA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		4 / 6 LEU A  77
ARG A  50
THR A  45
LEU A  44
 None
 1.03A 5x1fA-1usoA:
undetectable
5x1fJ-1usoA:
undetectable		 5x1fA-1usoA:
8.56
5x1fJ-1usoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 1uso HEPATOCYTE NUCLEAR
FACTOR 1-ALPHA
(Thermus
thermophilus) 		3 / 3 TRP A   3
GLU A   4
GLU A  54
 None
 1.01A 6fhwA-1usoA:
undetectable		 6fhwA-1usoA:
20.22