SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1usp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		4 / 6 LEU B 105
MET B 114
LEU B  62
HIS B 101
 None
None
None
GOL  B1140 (-4.2A)
 1.12A 1errB-1uspB:
undetectable		 1errB-1uspB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		4 / 5 LEU B 105
MET B 114
LEU B  62
HIS B 101
 None
None
None
GOL  B1140 (-4.2A)
 1.07A 2qxsB-1uspB:
undetectable		 2qxsB-1uspB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		4 / 8 LEU B  49
LEU B  28
SER B  31
ASN B  45
 None
 0.83A 3lm8A-1uspB:
undetectable
3lm8C-1uspB:
undetectable		 3lm8A-1uspB:
19.09
3lm8C-1uspB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		5 / 11 LEU B 113
LEU B 135
VAL B  65
GLY B  63
ALA B  61
 None
 1.12A 3pghB-1uspB:
undetectable		 3pghB-1uspB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		5 / 12 LEU B 113
LEU B 135
VAL B  65
GLY B  63
ALA B  61
 None
 1.04A 5ikrB-1uspB:
undetectable		 5ikrB-1uspB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		5 / 12 GLY B 112
HIS B 115
VAL B 137
ALA B 117
PHE B  58
 None
None
GOL  B1140 (-4.8A)
None
None
 1.04A 5n0tB-1uspB:
undetectable		 5n0tB-1uspB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1usp ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		3 / 3 LEU B 113
ALA B 110
LEU B  62
 None
GOL  B1140 (-3.6A)
None
 0.54A 5uunB-1uspB:
undetectable		 5uunB-1uspB:
18.73