SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1usw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		5 / 12 TYR A 186
VAL A  96
LEU A 141
ALA A 144
PHE A 168
 None
 1.08A 1gseB-1uswA:
undetectable		 1gseB-1uswA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		5 / 12 GLY A  99
LEU A 134
ILE A  48
ILE A 105
TRP A 104
 NAG  A1264 ( 4.8A)
None
None
None
None
 1.15A 1kyvA-1uswA:
undetectable
1kyvE-1uswA:
undetectable		 1kyvA-1uswA:
21.29
1kyvE-1uswA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		5 / 12 ILE A 105
TRP A 104
GLY A  99
LEU A 134
ILE A  48
 None
None
NAG  A1264 ( 4.8A)
None
None
 1.18A 1kyvB-1uswA:
undetectable
1kyvC-1uswA:
undetectable		 1kyvB-1uswA:
21.29
1kyvC-1uswA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		5 / 12 ILE A 105
TRP A 104
GLY A  99
LEU A 134
ILE A  48
 None
None
NAG  A1264 ( 4.8A)
None
None
 1.17A 1kyvC-1uswA:
undetectable
1kyvD-1uswA:
undetectable		 1kyvC-1uswA:
21.29
1kyvD-1uswA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		5 / 12 ILE A 105
TRP A 104
GLY A  99
LEU A 134
ILE A  48
 None
None
NAG  A1264 ( 4.8A)
None
None
 1.19A 1kyvD-1uswA:
undetectable
1kyvE-1uswA:
undetectable		 1kyvD-1uswA:
21.29
1kyvE-1uswA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 8 VAL A 115
THR A 128
TYR A 150
LEU A 146
 None
 0.97A 1z2bB-1uswA:
3.6		 1z2bB-1uswA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 8 ALA A 139
LEU A 141
ALA A 144
PHE A 168
 None
 0.87A 2vcvF-1uswA:
undetectable		 2vcvF-1uswA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		5 / 12 VAL A  96
GLY A 103
TYR A 100
ASN A  73
GLN A  45
 None
 1.39A 3bwmA-1uswA:
undetectable		 3bwmA-1uswA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		5 / 12 MET A 138
LEU A 141
THR A 142
ALA A 144
LEU A  88
 None
 1.17A 3hm1A-1uswA:
undetectable		 3hm1A-1uswA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		5 / 12 VAL A  96
GLY A 103
TYR A 100
ASN A  73
GLN A  45
 None
 1.39A 4xueB-1uswA:
undetectable		 4xueB-1uswA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 4 VAL A 211
VAL A 178
TYR A 186
GLN A 185
 None
 1.18A 5qggA-1uswA:
0.0		 5qggA-1uswA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 4 VAL A 211
VAL A 178
TYR A 186
GLN A 185
 None
 1.20A 5qgoA-1uswA:
0.0		 5qgoA-1uswA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 4 VAL A 211
VAL A 178
TYR A 186
GLN A 185
 None
 1.17A 5qgpA-1uswA:
0.0		 5qgpA-1uswA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 4 VAL A 211
VAL A 178
TYR A 186
GLN A 185
 None
 1.18A 5qgqA-1uswA:
0.0		 5qgqA-1uswA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 4 VAL A 211
VAL A 178
TYR A 186
GLN A 185
 None
 1.20A 5qhbA-1uswA:
0.0		 5qhbA-1uswA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 8 THR A  68
GLY A  67
GLY A 135
SER A 137
 None
 0.71A 5vw9A-1uswA:
undetectable		 5vw9A-1uswA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 7 ILE A  52
LEU A  53
ILE A  48
ALA A  23
 None
 0.66A 6b5vA-1uswA:
undetectable
6b5vC-1uswA:
undetectable		 6b5vA-1uswA:
14.62
6b5vC-1uswA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 7 ALA A  23
ILE A  52
LEU A  53
ILE A  48
 None
 0.64A 6b5vA-1uswA:
undetectable
6b5vB-1uswA:
undetectable		 6b5vA-1uswA:
14.62
6b5vB-1uswA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 7 ILE A  52
LEU A  53
ILE A  48
ALA A  23
 None
 0.68A 6b5vC-1uswA:
undetectable
6b5vD-1uswA:
undetectable		 6b5vC-1uswA:
14.62
6b5vD-1uswA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1usw FERULOYL ESTERASE A
(Aspergillus
niger) 		4 / 7 ALA A  23
ILE A  52
LEU A  53
ILE A  48
 None
 0.66A 6b5vB-1uswA:
undetectable
6b5vD-1uswA:
undetectable		 6b5vB-1uswA:
14.62
6b5vD-1uswA:
14.62